Head of Biomedical Research Center
+420 495 833 447
ondrej.soukup@fnhk.cz
ORCID: 0000-0001-6376-8701
Ondrej obtained his PhD in 2011 at the University of Defence in Hradec Kralove. The main aim of the thesis was to characterize non-reactivating effects of cholinesterase reactivators as the antidotes against organophosphorus poisoning. Currently, as a postdoctoral fellow at the Biomedical Research Center (BRC), University Hospital Hradec Kralove, is responsible development and testing of new therapeutics for Alzheimer's disease and organophosphorus poisoning. Besides the scientific activity, Ondrej is devoted to the students supervising, teaching and works as a deputy-chief at the BRC.
| Assoc. professor | (2018) |
University of Defence Faculty of Military Health Sciences, Hradec Kralove, Czech Republic |
| Ph.D. | (2011) |
University of Defence Faculty of Military Health Sciences, Hradec Kralove, Czech Republic Disertation thesis title: „Interaction of organophosphorus poisoning antidotes with muscarinic and nicotinic receptors |
| PharmDr. | (2011) | Charles University, Faculty of Pharmacy, Department of Pharmacology and Toxicology |
| Mgr. | (2007) |
Charles University, Faculty of Pharmacy in Hradec Kralove Master thesis title: „Muscarinic receptors in the regulation of vascular percussion mechanisms in the rat and sheep salivary gland |
Screening of biological properties of the new compounds, their interaction with cholinergic receptors and the determination of their cytotoxic effects
|
Since 2018 Since 2011 |
Head, Biomedical Research Center (BRC), University hospital Hradec Kralove Postdoctoral fellow, Biomedical Research Center (BRC), University Hospital Hradec Kralove |
| Since 2011 | Research fellow, Department of Public Health, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic |
| 2007–2011 | PhD student, Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove |
|
2009,2014 2015 |
Entitled to work with laboratory animals according the Law Entitled for being the Supervising person for handling radionuclides |
|
9/2016 3/2015 4/ 2013 11/2011 |
FFI, Kjeller, Norway (1 month, post-doctor intership) Univ. of Gothenburg, Sahlgrenska Academy, Dpt. of Pharmacology (2 month, post-doctor intership) University of St. Andrews, Department of Cell Biology (2 month) University of Leicester, Department of Cell Physiology and Pharmacology (3 weeks) |
| 11/2010 | University of United Arab Emirates, Department of Pharmacology and Toxicology, Al Ain (3 weeks) |
| 2007–2010 | University of Gothenburg, Sahlgrenska Academy, Department of Pharmacology (8 months total) |
Czech Research Council member and reviewer – board 306
| 2020–2023 | Grant Agency for Health Research of the Czech Republic: Dually acting cognitive enhancers for palliative treatment of Alzheimer´s disease (main investigator) |
| 2020–2022 | Grant Agency of Czech Republic: Novel neuroprotective compounds based on NMDA receptor antagonism and cholinergic stimulation (main investigator) |
| 2019–2023 | IT4Neuro(degeneration), OP VVV project (co-investigator) |
| 2019–2021 | Grant Agency of Czech Republic: Specific serotonin-dopamin modulators and their potential in the model of induced psychosis (main investigator) |
| 2017–2020 | Grant Agency of Czech Republic: Specific serotonin-dopamin modulators and their potential in the model of induced psychosis (main investigator) |
| 2017 | Czech –Norwegian research programme: Development of Czech-Norwegian cooperation in the treatment of organophosphorus poisoning (main investigator) |
| 2017 |
Grant Agency of Czech Republic: Novel hybrid compounds in the cognitive decline caused by neurodegeneration (co-investigator) |
| 2016–2018 |
Grant Agency of Czech Republic: Novel hybrid compounds in the cognitive decline caused by neurodegeneration (co-investigator) |
| 2015–2018 |
Grant Agency for Health Research of the Czech Republic: Development of novel disinfectants against pathogens occuring in the hospital environment (main investigator) |
Since 2013 University of St. Andrews, Department of Cell Biology
| Since 2007 | The Sahlgrenska Academy, University of Gothenburg, Sweden |
|
Students
2009 2012–2016 Since 2016 Since 2019 |
Bc. 3 MSc. 3 Ph.D. 2 Lecturing Pharmacology and Toxicology at the Faculty of Pharmacy in Hradec Kralove Lecturing Biochemistry at the University of Hradec Kralove, Faculty of Science Lecturing in the studying block for PhD students Lecturing Toxicology, Faculty of military Health Sciences, University of defense |
| 2011 | Nominee for a Prize of the Mayor of Hradce Kralove for research activities |
| 2012 | Awarded by the Medal of Hradce Kralove for research activities |
(dated 4/2020)
Honegr, Jan; Maliňák, Dávid; Doležal, Rafael; Soukup, Ondřej; Benková, Markéta; Hroch, Lukáš; Benek, Ondřej; Janočková, Jana; Kuča, Kamil; Prymula, Roman: Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro. In: European Journal of Medicinal Chemistry, 2018, roč. 146, č. February. s. 38-46. IF 4.519.
Mezeiová, Eva; Špilovská, Katarína; Nepovimová, Eugenie; Górecki, Lukáš; Soukup, Ondřej; Doležal, Rafael; Maliňák, Dávid; Janočková, Jana; Jun, Daniel; Kuča, Kamil; Korábečný, Jan: Profiling donepezil template into multipotent hybrids with antioxidant properties. In: Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, roč. 33, č. 1. s. 583-606. IF 4.293.
Babková, Kateřina; Korábečný, Jan; Soukup, Ondřej; Nepovimová, Eugenie; Jun, Daniel; Kuča, Kamil: Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors. In: Future Medicinal Chemistry, 2017, roč. 9, č. 10. s. 1015-1038. IF 3.556.
Bautista-Aguilera, Oscar M.; Hagenow, Stefanie; Palomino-Antolin, Alejandra; Farre-Alins, Victor; Ismaili, Lhassane; Joffrin, Pierre-Louis; Jimeno, Maria L.; Soukup, Ondřej; Janočková, Jana; Kalinowsky, Lena; Proschak, Ewgenij; Iriepa, Isabel; Moraleda, Ignacio; Schwed, Johannes S.; Romero Martinez, Alejandro; Lopez-Munoz, Francisco; Chioua, Mourad; Egea, Javier; Ramsay, Rona R.; Marco-Contelles, Jose; Stark, Holger: Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases. In: Angewandte Chemie - International Edition, 2017, roč. 56, č. 41. s. 12765-12769. IF 11.994.
De Simone, Angela; Bartolini, Manuela; Baschieri, Andrea; Apperley, Kim Y. P.; Chen, Huan Huan; Guardigni, Melissa; Montanari, Serena; Kobrlová, Tereza; Soukup, Ondřej; Valgimigli, Luca; Andrisano, Vincenza; Keillor, Jeffrey W.; Basso, Manuela; Milelli, Andrea: Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease. In: European Journal of Medicinal Chemistry, 2017, roč. 139, č. October. s. 378-389. IF 4.519.
Dgachi, Youssef; Sokolov, Olga; Luzet, Vincent; Godyn, Justyna; Panek, Dawid; Bonet, Alexandre; Martin, Helene; Iriepa, Isabel; Moraleda, Ignacio; Garcia-Iriepa, Cristina; Janočková, Jana; Richert, Lysiane; Soukup, Ondřej; Malawska, Barbara; Chabchoub, Fakher; Marco-Contelles, Jose; Ismaili, Lhassane: Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy. In: European Journal of Medicinal Chemistry, 2017, roč. 126, č. January. s. 576-589. IF 4.519.
Gazova, Zuzana; Soukup, Ondřej; Šepsová, Vendula; Siposova, Katarina; Drtinová, Lucie; Jošt, Petr; Špilovská, Katarína; Korábečný, Jan; Nepovimová, Eugenie; Fedunová, Diana; Horák, Martin; Kaniaková, Martina; Wang, Ze-Jun; Hamouda, Ayman K.; Kuča, Kamil: Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment. In: Biochimica et Biophysica Acta - Molecular Basis of Disease, 2017, roč. 1863, č. 2. s. 607-619. IF 5.476.
Górecki, Lukáš; Korábečný, Jan; Musílek, Kamil; Nepovimová, Eugenie; Maliňák, Dávid; Kučera, Tomáš; Doležal, Rafael; Jun, Daniel; Soukup, Ondřej; Kuča, Kamil: Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016). In: Expert Opinion on Therapeutic Patents, 2017, roč. 27, č. 9. s. 971-985. IF 3.041.
Hamuláková, Slávka; Janovec, Ladislav; Soukup, Ondřej; Jun, Daniel; Kuča, Kamil: Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids. In: International Journal of Biological Macromolecules, 2017, roč. 104, č. Part A. s. 333-338. IF 3.671.
Horak, Martin; Holubova, Kristina; Nepovimová, Eugenie; Krusek, Jan; Kaniakova, Martina; Korábečný, Jan; Vyklicky, Ladislav; Kuča, Kamil; Stuchlik, Ales; Ricny, Jan; Vales, Karel; Soukup, Ondřej: The pharmacology of tacrine at N-methyl-D-aspartate receptors. In: Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2017, roč. 75, č. April. s. 54-62. IF 4.187.
Jeřábek, Jakub; Uliassi, Elisa; Guidotti, Laura; Korábečný, Jan; Soukup, Ondřej; Šepsová, Vendula; Hrabinová, Martina; Kuča, Kamil; Bartolini, Manuela; Pena-Altamira, Luis Emiliano; Petralla, Sabrina; Monti, Barbara; Roberti, Marinella; Bolognesi, Maria Laura: Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease. In: European Journal of Medicinal Chemistry, 2017, roč. 127, č. February. s. 250-262. IF 4.519.
Kristofikova, Zdenka; Ricny, Jan; Soukup, Ondřej; Korábečný, Jan; Nepovimová, Eugenie; Kuča, Kamil; Ripova, Daniela: Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1. In: Dementia and Geriatric Cognitive Disorders, 2017, roč. 43, č. 1-2. s. 45-58. IF 3.511.
Kuča, Kamil; Korábečný, Jan; Doležal, Rafael; Nepovimová, Eugenie; Soukup, Ondřej; Górecki, Lukáš; Musílek, Kamil: Tetroxime: reactivation potency - in vitro and in silico study. In: RSC Advances, 2017, roč. 7, č. 12. s. 7041-7045. IF 3.108.
Němeček, Jan; Sychra, Pavel; Macháček, Miloslav; Benková, Markéta; Karabanovich, Galina; Konečná, Klára; Kavková, Věra; Stolaříková, Jiřina; Hrabálek, Alexandr; Vávrová, Kateřina; Soukup, Ondřej; Roh, Jaroslav; Klimešová, Věra: Structure-activity relationship studies on 3,5-dinitrophenyl tetrazoles as antitubercular agents. In: European Journal of Medicinal Chemistry, 2017, roč. 130, č. April. s. 419-432. IF 4.519.
Panek, Dawid; Wieckowska, Anna; Wichur, Tomasz; Bajda, Marek; Godyn, Justyna; Jonczyk, Jakub; Mika, Kamil; Janočková, Jana; Soukup, Ondřej; Knez, Damijan; Korábečný, Jan; Gobec, Stanislav; Malawska, Barbara: Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation. In: European Journal of Medicinal Chemistry, 2017, roč. 125, č. January. s. 676-695. IF 4.519.
Soukup, Ondřej; Winder, Michael; Killi, Uday Kumar; Wsól, Vladimír; Jun, Daniel; Kuča, Kamil; Tobin, Gunnar: Acetylcholinesterase inhibitors and drugs acting on muscarinic receptors-potential crosstalk of cholinergic mechanisms during pharmacological treatment. In: Current Neuropharmacology, 2017, roč. 15, č. 4. s. 637-653. IF 3.365.
Andrš, Martin; Muthná, Darina; Řezáčová, Martina; Seifrtová, Martina; Šiman, Pavel; Korábečný, Jan; Benek, Ondřej; Doležal, Rafael; Soukup, Ondřej; Jun, Daniel; Kuča, Kamil: Novel caffeine derivatives with antiproliferative activity. In: RSC Advances, 2016, roč. 6, č. 39. s. 32534-32539. IF 3.108.
Benek, Ondřej; Soukup, Ondřej; Pasdiorová, Markéta; Hroch, Lukáš; Šepsová, Vendula; Jošt, Petr; Hrabinová, Martina; Jun, Daniel; Kuča, Kamil; Zala, Dominykas; Ramsay, Rona R.; Marco-Contelles, José; Musílek, Kamil: Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease. In: ChemMedChem, 2016, roč. 11, č. 12. s. 1264-1269. IF 3.225.
Benchekroun, Mohamed; Romero, Alejandro; Egea, Javier; Leon, Rafael; Michalska, Patrycja; Buendia, Izaskun; Jimeno, Maria Luisa; Jun, Daniel; Janočková, Jana; Šepsová, Vendula; Soukup, Ondřej; Bautista-Aguilera, Oscar M.; Refouvelet, Bernard; Ouari, Olivier; Marco-Contelles, Jose; Ismaili, Lhassane: The antioxidant additive approach for Alzheimer's disease therapy: New ferulic (Lipoic) acid plus melatonin modified tacrines as Cholinesterases inhibitors, direct antioxidants, and nuclear factor (Erythroid-Derived 2)-like 2 activators. In: Journal of Medicinal Chemistry, 2016, roč. 59, č. 21. s. 9967-9973. IF 6.259.
Doležal, Rafael; Soukup, Ondřej; Maliňák, Dávid; Savedra M.L., Ranylson; Marek, Jan; Doležalová, Marie; Pasdiorová, Markéta; Salajková, Šárka; Korábečný, Jan; Honegr, Jan; Ramalho C., Teodorico; Kuča, Kamil: Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies. In: European Journal of Medicinal Chemistry, 2016, roč. 121, č. October. s. 699-711. IF 4.519.
Górecki, Lukáš; Korábečný, Jan; Musílek, Kamil; Maliňák, Dávid; Nepovimová, Eugenie; Doležal, Rafael; Jun, Daniel; Soukup, Ondřej; Kuča, Kamil: SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides. In: Archives of Toxicology, 2016, roč. 90, č. 12. s. 2831-2859. IF 5.901.
Hamulakova, Slavka; Poprac, Patrik; Jomova, Klaudia; Brezova, Vlasta; Lauro, Peter; Drostinova, Lenka; Jun, Daniel; Šepsová, Vendula; Hrabinová, Martina; Soukup, Ondřej; Kristian, Pavol; Gazova, Zuzana; Bednarikova, Zuzana; Kuča, Kamil; Valko, Marian: Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules. In: Journal of Inorganic Biochemistry, 2016, roč. 161, č. August. s. 52-62. IF 3.348.
Nunes Lemes, Lais Flavia; Ramos, Giselle de Andrade; de Oliveira, Andressa Souza; da Silva, Fernanda Motta R.; Couto, Gina de Castro; Boni, Marina da Silva; Guimaraes, Marcos Jorge R.; Souza, Isis Nem O.; Bartolini, Manuela; Andrisano, Vincenza; do Nascimento Nogueira, Patricia Coelho; Silveira, Edilberto Rocha; Brand, Guilherme D.; Soukup, Ondřej; Korábečný, Jan; Romeiro, Nelilma C.; Castro, Newton G.; Bolognesi, Maria Laura; Soares Romeiro, Luiz Antonio: Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease. In: European Journal of Medicinal Chemistry, 2016, roč. 108, č. January. s. 687-700. IF 4.519.
Prati, Federica; Bergamini, Christian; Fato, Romana; Soukup, Ondřej; Korábečný, Jan; Andrisano, Vincenza; Bartolini, Manuela; Bolognesi, Maria Laura: Novel 8-Hydroxyquinoline derivatives as multitarget compounds for the treatment of Alzheimer's disease. In: ChemMedChem, 2016, roč. 11, č. 12, Spec. Iss.. s. 1284-1295. IF 3.225.
Špilovská, Katarína; Zemek, Filip; Korábečný, Jan; Nepovimová, Eugenie; Soukup, Ondřej; Windisch, Manfred; Kuča, Kamil: Adamantane - A lead structure for drugs in clinical practice. In: Current Medicinal Chemistry, 2016, roč. 23, č. 29. s. 3245-3266. IF 3.249.
Honegr, Jan; Soukup, Ondřej; Doležal, Rafael; Maliňák, Dávid; Penhaker, Marek; Prymula, Roman; Kuča, Kamil: Structural Properties of Potential Synthetic Vaccine Adjuvants - TLR Agonists. In: Current Medicinal Chemistry, 2015, roč. 22, č. 29. s. 3306-3325. IF 3.249.
Nepovimová, Eugenie; Korábečný, Jan; Doležal, Rafael; Babková, Kateřina; Ondřejíček, Aleš; Jun, Daniel; Šepsová, Vendula; Horová, Anna; Hrabinová, Martina; Soukup, Ondřej; Bukum, Neslihan; Jošt, Petr; Múčková, Ľubica; Kassa, Jiří; Maliňák, Dávid; Andrš, Martin; Kuča, Kamil: Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity. In: Journal of Medicinal Chemistry, 2015, roč. 58, č. 22. s. 8985-9003. IF 6.259.
Soukup, O. et al. A Resurrection of 7-MEOTA: A Comparison with Tacrine. Curr Alz Res 2013, Oct;10(8):893-906
Soukup, O. el al. The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors. Arch Tox 2013, Apr;87(4):711-9
Patocka, J,; Soukup, O; Kuca, K. Resorcylic Acid lactones as the protein kinase inhibitors , naturally occuring toxins. Mini rev med chem 2013, Nov;13(13):1873-8
Soukup, O.; Kristofikova, Z.; Jun, D.; Tambor, V.; Ripova, D.; Kuca, K. The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers. Toxicol Lett 2012, 212, 315-319.
Soukup, O.; Krusek, J.; Kaniakova, M.; Kumar, U.K.; Oz, M.; Jun, D.; Fusek, J.; Kuca, K.; Tobin, G. Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors. Phys. Res. 2011, 60, 679-686.
Soukup, O.; Kumar, U.K.; Proska, J.; Bratova, L.; Adem, A.; Jun, D.; Fusek, J.; Kuca, K.; Tobin, G. The effect of oxime reactivators on muscarinic receptors: Functional and binding examinations. Environ. Toxicol. Pharmacol. 2011, 31, 364-370.
Soukup, O.; Tobin, G.; Kumar, U.K.; Binder, J.; Proska, J.; Jun, D.; Fusek, J.; Kuca, K. Interaction of Nerve Agent Antidotes with Cholinergic Systems. Curr. Med. Chem. 2010, 17, 1708-1718.
Soukup, O.; Kristofikova, Z.; Proska, J.; Tobin, G.; Patocka, J.; Marek, J.; Jun, D.; Fusek, J.; Ripova, D.; Kuca, K. Novel acetylcholinesterase reactivator K112 and its cholinergic properties. Biomed. Pharmacother. 2010, 64, 541-545.
Soukup, O.; Holas, O.; Binder, J.; Killy, K.; Tobin, G.; Jun, D.; Fusek, J.; Kuca, K. The effect of trimedoxime on acetylcholinesterase and on the cholinergic system of the rat bladder. J. Appl. Biomed. 2010, 8, 87-92.
Soukup, O.; Tobin, G.; Kumar, U.K.; Jun, D.; Fusek, J.; Kuca, K. Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder. Toxicol. Mech. Methods 2010, 20, 428-433.
