Górecki Lukáš

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Postdoctoral fellow
LukasGorecki@seznam.cz
ORCID: 0000-0002-4791-6556
Researcher ID: N-9017-2019
ResearchGate: https://www.researchgate.net/profile/Lukas_Gorecki

Dr. Lukas Gorecki graduated from Charles University, Faculty of Pharmacy in Hradec Kralove. He obtained his Ph.D. in the Department of Toxicology and Military Pharmacy at the Faculty of Military Health Sciences, University of Defense, where he focused on the design and synthesis of cholinesterase modulators. During his Ph.D. studies, he completed internships at the University of Bologna, studying new drugs for Alzheimer’s disease under the supervision of Prof. Bolognesi, and at the University of California, San Diego, where he studied antidotes against nerve agents. After completing his Ph.D., he worked as a postdoctoral researcher at the Biomedical Research Center, University Hospital Hradec Kralove (BRC UHHK), where he continued his research on novel antidotes against nerve agents. He was also involved in developing chemotherapeutics for individualized anticancer approaches, and is an important team member in various national and international projects, including the NIH CounterAct R21 and European JPND. In the summer of 2022, Dr. Gorecki joined the Czech Army at the rank of captain as a senior assistant at the Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense. He continues to be involved in cancer research at BRC UHHK. A part of the broad publication activity, he has co-authored one international and two national patent applications.

Education

Research focus

Medicinal chemistry – project management, design, synthesis, structure‑activity relationships, and basic biochemical evaluation in novel cholinesterases modulators and chemotherapeutics for individualized anticancer approach.

Toxicology – research and outlook on protection against chemical warfare agents, with particular interest in nerve agents

Professional training

International experiences

International co-operations

• prof. Maria Laura Bolognesi, Universita di Bologna, development of MTDL drugs for neurodegenerative diseases (1 mutual publication)
• assoc. prof. Zoran Radić, SSPPS UCSD, development of cholinesterase reactivators (1 mutual publication)
• assoc. prof. Zrinka Kovarik, University of Zagreb, Institute for Medical Research and Occupational Health, development of cholinesterase reactivators
• dr. Sven Marcel Stefan, University of Oslo, Department of Neuro-/Pathology, development of ABC transporters (1 mutual publication)
• dr. Florian Nachon, Département de Toxicologie et Risques Chimiques Division Défense NRBC, development of cholinesterase reactivators (1 mutual publication)
• prof. Franz Worek, Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany, development of cholinesterase reactivators (1 mutual publication)

Research projects

• Principal investigator or co‑investigator - 22-05318S (principal co‑investigator, 2022-2024)
• Team member of projects – 21-03000S (team member, 2021-2023), 17-07585Y (team member, 2020), DZRO-ZHN-2017 (team member, 2017-2021), CZ.02.1.01/0.0/0.0.18_069/0010046 (team member, 2019-2022), CZ.02.1.01/0.0/0.0.18_069/0010054 (team member, 2019-2022),

Further extracurricular activities

Awards

Publication acitivity

Author or co‑author 28 scientific publications with IF

H-Index: 12 (WoS)

Citations without autocitations: 385

(dated 03/2023)

Selected publications in last five years

(1)       Gorecki, L.; Soukup, O.; Korabecny, J. Countermeasures in Organophosphorus Intoxication: Pitfalls and Prospects. Trends Pharmacol. Sci. 2022, 43 (7), 593–606. https://doi.org/10.1016/j.tips.2022.04.008. IF₂₀₂₁ = 17.638 (first author)

(2)       Gorecki, L.; Muthna, D.; Merdita, S.; Andrs, M.; Kucera, T.; Havelek, R.; Muckova, L.; Kobrlova, T.; Soukup, J.; Krupa, P.; Prchal, L.; Soukup, O.; Roh, J.; Rezacova, M.; Korabecny, J. 7-Azaindole, 2,7-Diazaindole, and 1H-Pyrazole as Core Structures for Novel Anticancer Agents with Potential Chemosensitizing Properties. Eur. J. Med. Chem. 2022, 240, 114580. https://doi.org/10.1016/j.ejmech.2022.114580. IF₂₀₂₁ = 7.088 (first author)

(3)       Gorecki, L.; Andrs, M.; Korabecny, J. Clinical Candidates Targeting the ATR–CHK1–WEE1 Axis in Cancer. Cancers 2021, 13 (4), 795. https://doi.org/10.3390/cancers13040795. IF₂₀₂₁ = 6.575 (first author)

(4)       Gorecki, L.; Uliassi, E.; Bartolini, M.; Janockova, J.; Hrabinova, M.; Hepnarova, V.; Prchal, L.; Muckova, L.; Pejchal, J.; Karasova, J. Z.; Mezeiova, E.; Benkova, M.; Kobrlova, T.; Soukup, O.; Petralla, S.; Monti, B.; Korabecny, J.; Bolognesi, M. L. Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer’s Disease. ACS Chem. Neurosci. 2021, 12 (9), 1698–1715. https://doi.org/10.1021/acschemneuro.1c00184. IF₂₀₂₁ = 5.780 (first author)

(5)       Gorecki, L.; Misiachna, A.; Damborsky, J.; Dolezal, R.; Korabecny, J.; Cejkova, L.; Hakenova, K.; Chvojkova, M.; Karasova, J. Z.; Prchal, L.; Novak, M.; Kolcheva, M.; Kortus, S.; Vales, K.; Horak, M.; Soukup, O. Structure-Activity Relationships of Dually-Acting Acetylcholinesterase Inhibitors Derived from Tacrine on N-Methyl-d-Aspartate Receptors. Eur. J. Med. Chem. 2021, 219, 113434. https://doi.org/10.1016/j.ejmech.2021.113434. IF₂₀₂₁ = 7.088 (first author)

(6)       Gorecki, L.; Andrs, M.; Rezacova, M.; Korabecny, J. Discovery of ATR Kinase Inhibitor Berzosertib (VX-970, M6620): Clinical Candidate for Cancer Therapy. Pharmacol. Ther. 2020, 107518. https://doi.org/10.1016/j.pharmthera.2020.107518. IF₂₀₂₀ = 12.31 (first author)

(7)       Gorecki, L.; Gerlits, O.; Kong, X.; Cheng, X.; Blumenthal, D. K.; Taylor, P.; Ballatore, C.; Kovalevsky, A.; Radić, Z. Rational Design, Synthesis, and Evaluation of Uncharged, “Smart” Bis-Oxime Antidotes of Organophosphate-Inhibited Human Acetylcholinesterase. J. Biol. Chem. 2020, 295 (13), 4079–4092. https://doi.org/10.1074/jbc.RA119.012400. IF₂₀₂₀ = 5.157 (first author)

(8)       Namasivayam, V.; Stefan, K.; Gorecki, L.; Korabecny, J.; Soukup, O.; Jansson, P. J.; Pahnke, J.; Stefan, S. M. Physicochemistry Shapes Bioactivity Landscape of Pan-ABC Transporter Modulators: Anchor Point for Innovative Alzheimer’s Disease Therapeutics. Int. J. Biol. Macromol. 2022, 217, 775–791. https://doi.org/10.1016/j.ijbiomac.2022.07.062. IF₂₀₂₁ = 8.025 (co-author)

(9)       Gorecki, L.; Hepnarova, V.; Karasova, J. Z.; Hrabinova, M.; Courageux, C.; Dias, J.; Kucera, T.; Kobrlova, T.; Muckova, L.; Prchal, L.; Malinak, D.; Jun, D.; Musilek, K.; Worek, F.; Nachon, F.; Soukup, O.; Korabecny, J. Development of Versatile and Potent Monoquaternary Reactivators of Acetylcholinesterase. Arch. Toxicol. 2021, 95 (3), 985–1001. https://doi.org/10.1007/s00204-021-02981-w. IF₂₀₂₁ = 5.153 (first author)

(10)     Gorecki, L.; Soukup, O.; Kucera, T.; Malinak, D.; Jun, D.; Kuca, K.; Musilek, K.; Korabecny, J. Oxime K203: A Drug Candidate for the Treatment of Tabun Intoxication. Arch. Toxicol. 2019, 93 (3), 673–691. https://doi.org/10.1007/s00204-018-2377-7. IF₂₀₁₉ = 5.059 (first author)