Postdoctoral fellow
LukasGorecki@seznam.cz
ORCID: 0000-0002-4791-6556
Researcher ID: N-9017-2019
Dr. Lukas Gorecki graduated from Charles University, Faculty of Pharmacy in Hradec Kralove. He continued as postgraduate student at the Department of Toxicology and Military pharmacy, Faculty of Military Health Sciences, University of Defense, where he was dealing with design and synthesis of cholinesterases modulators. Throughout his Ph.D. studies it included various fields of these enzymes that were inspected. However, his main topic is introduction of novel acetylcholinesterase reactivators as antidotes against organophosphorous compounds, such as Nerve Agents that are considered the most toxic chemical weapons of mass destruction. This was also the subject of his internship at UCSD. Currently, he is employed as postdoc at Biomedical Research Center, University Hospital Hradec Kralove, where he continues with search for novel antidotes against Nerve Agents. Besides, he is now fulltime involved as young researcher in design and synthesis of novel ATR selective inhibitors as modern and very perspective anticancer treatment.
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PharmDr. |
(2019) |
Charles University, Faculty of Pharmacy in Hradec Kralove (master thesis: Development of novel cholinesterase modulators) |
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PhD. |
(2015–2019) |
University of Defense, Faculty of Military Health Sciences, Department of Toxicology and Military pharmacy (doctor thesis: Development of novel cholinesterase modulators) |
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MSc. |
(2010–2015) |
Charles University, Faculty of Pharmacy in Hradec Kralove (master thesis: Preparation of chiral quinazoline derivatives) |
Medicinal chemistry – design, synthesis, structure‑activity relationships, project management in ATR selective inhibitors and novel cholinesterases modulators
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2020 |
Researcher fellow at the First Faculty of Medicine Charles University in Prague and General University Hospital in Prague; Department of Psychiatry |
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Since 2015 |
Researcher fellow at the Biomedical Research Center; University Hospital in Hradec Kralove, (from 2019 employed as Postdoc) |
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Since 2015 |
Researcher fellow at the Department of Toxicology and Military pharmacy, Faculty of Military Health and Sciences, University of Defense |
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2015–2019 |
PhD student, Department of Toxicology and Military pharmacy, Faculty of Military Health and Sciences, University of Defense |
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2018 |
four and half months’ internship – Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD (La Jolla, USA), under supervision of assoc. prof. Zoran Radić; assoc. prof. Carlo Ballatore and prof. Palmer Taylor. Design, synthesis and in vitro determination of novel highly potent reactivators of acetylcholinesterase for the treatment of organophosphorus intoxication. |
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2017 |
three months’ internship – Bologna (Italy), under supervision of prof. Maria Laura Bolognesi (JMC Editor). Synthesis of the MTDL compounds based on tacrine and phenothiazine derivatives as drugs against Alzheimer’s disease. |
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Since 2017 |
appointed as an evaluator in the National accreditation authority for the higher education in Czech Republic; field Pharmacy |
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2018 |
Faculty of Military Health Sciences Dean’s award for scientific contribution in 2018 |
Author or co‑author 17 scientific publications with IF
H-Index: 5 (WoS)
Citations without autocitations: 121
(dated 04/2020)
Gorecki, L.; Gerlits, O.; Kong, X.; Cheng, X.; Blumenthal, D. K.; Taylor, P.; Ballatore, C.; Kovalevsky, A.; Radić, Z. Rational Design, Synthesis and Evaluation of Uncharged, “Smart” Bis-Oxime Antidotes of Organophosphate-Inhibited Human Acetylcholinesterase. J. Biol. Chem. 2020, jbc.RA119.012400. https://doi.org/10.1074/jbc.RA119.012400.
Gorecki, L.; Andrs, M.; Rezacova, M.; Korabecny, J. Discovery of ATR Kinase Inhibitor Berzosertib (VX-970, M6620): Clinical Candidate for Cancer Therapy. Pharmacol. Ther. 2020, 107518. https://doi.org/10.1016/j.pharmthera.2020.107518.
Gorecki, L.; Junova, L.; Kucera, T.; Hepnarova, V.; Prchal, L.; Kobrlova, T.; Muckova, L.; Soukup, O.; Korabecny, J. Tacroximes: Novel Unique Compounds for the Recovery of Organophosphorus-Inhibited Acetylcholinesterase. Future Med. Chem. 2019, 11 (20), 2625–2634. https://doi.org/10.4155/fmc-2019-0027.
Gorecki, L.; Korabecny, J.; Musilek, K.; Malinak, D.; Nepovimova, E.; Dolezal, R.; Jun, D.; Soukup, O.; Kuca, K. SAR Study to Find Optimal Cholinesterase Reactivator against Organophosphorous Nerve Agents and Pesticides. Arch. Toxicol. 2016, 90 (12), 2831–2859. https://doi.org/10.1007/s00204-016-1827-3.
Gorecki, L.; Soukup, O.; Kucera, T.; Malinak, D.; Jun, D.; Kuca, K.; Musilek, K.; Korabecny, J. Oxime K203: A Drug Candidate for the Treatment of Tabun Intoxication. Arch. Toxicol. 2019, 93 (3), 673–691. https://doi.org/10.1007/s00204-018-2377-7.
