Górecki Lukáš | Centrum biomedicínského výzkumu

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Górecki Lukáš

Info

For Czech version click here

Postdoctoral fellow
LukasGorecki@seznam.cz
ORCID: 0000-0002-4791-6556
Researcher ID: N-9017-2019
ResearchGate: https://www.researchgate.net/profile/Lukas_Gorecki


Dr. Lukas Gorecki graduated from Charles University, Faculty of Pharmacy in Hradec Kralove. He obtained his Ph.D. in the Department of Toxicology and Military Pharmacy at the Faculty of Military Health Sciences, University of Defense, where he focused on the design and synthesis of cholinesterase modulators. During his Ph.D. studies, he completed internships at the University of Bologna, studying new drugs for Alzheimer’s disease under the supervision of Prof. Bolognesi, and at the University of California, San Diego, where he studied antidotes against nerve agents. After completing his Ph.D., he worked as a postdoctoral researcher at the Biomedical Research Center, University Hospital Hradec Kralove (BRC UHHK), where he continued his research on novel antidotes against nerve agents. He was also involved in developing chemotherapeutics for individualized anticancer approaches, and is an important team member in various national and international projects, including the NIH CounterAct R21 and European JPND. In the summer of 2022, Dr. Gorecki joined the Czech Army at the rank of captain as a senior assistant at the Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense. He continues to be involved in cancer research at BRC UHHK. A part of the broad publication activity, he has co-authored one international and two national patent applications.

 

Education

MSc.

(2010–2015)

Charles University, Faculty of Pharmacy in Hradec Kralove (master thesis: Preparation of chiral quinazoline derivatives) 

PhD.

(2015–2019)

University of Defense, Faculty of Military Health Sciences, Department of Toxicology and Military pharmacy (doctor thesis: Development of novel cholinesterase modulators)

PharmDr.

(2019)

Charles University, Faculty of Pharmacy in Hradec Kralove (rigorous thesis: Development of novel cholinesterase modulators)

 

Research focus

Medicinal chemistry – project management, design, synthesis, structure‑activity relationships, and basic biochemical evaluation in novel cholinesterases modulators and chemotherapeutics for individualized anticancer approach.

Toxicology – research and outlook on protection against chemical warfare agents, with particular interest in nerve agents

 

Professional training

2015–2019

PhD student, Department of Toxicology and Military pharmacy, Faculty of Military Health and Sciences, University of Defense

Since 2015

Researcher fellow at the Department of Toxicology and Military pharmacy, Faculty of Military Health and Sciences, University of Defense

Since 2015

Researcher fellow at the Biomedical Research Center; University Hospital in Hradec Kralove, (from 2019 employed as Postdoc)

2020

Researcher fellow at the First Faculty of Medicine Charles University in Prague and General University Hospital in Prague; Department of Psychiatry

Since 2021

Lector of biochemical laboratory practices at the Faculty of Medicine in Hradec Kralove, Charles University

 

International experiences

2017

three months’ internship – Bologna (Italy), under supervision of prof. Maria Laura Bolognesi (JMC Editor). Synthesis of the MTDL compounds based on tacrine and phenothiazine derivatives as drugs against Alzheimer’s disease

2018

five months’ internship – Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD (La Jolla, USA), under supervision of assoc. prof. Zoran Radić; assoc. prof. Carlo Ballatore and prof. Palmer Taylor. Design, synthesis and in vitro determination of novel highly potent reactivators of acetylcholinesterase for the treatment of organophosphorus intoxication

 

International co-operations

  • prof. Maria Laura Bolognesi, Universita di Bologna, development of MTDL drugs for neurodegenerative diseases (1 mutual publication)
  • assoc. prof. Zoran Radić, SSPPS UCSD, development of cholinesterase reactivators (1 mutual publication)
  • assoc. prof. Zrinka Kovarik, University of Zagreb, Institute for Medical Research and Occupational Health, development of cholinesterase reactivators
  • dr. Sven Marcel Stefan, University of Oslo, Department of Neuro-/Pathology, development of ABC transporters (1 mutual publication)
  • dr. Florian Nachon, Département de Toxicologie et Risques Chimiques Division Défense NRBC, development of cholinesterase reactivators (1 mutual publication)
  • prof. Franz Worek, Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany, development of cholinesterase reactivators (1 mutual publication)

 

Research projects

  • Principal investigator or co‑investigator - 22-05318S (principal co‑investigator, 2022-2024)
  • Team member of projects – 21-03000S (team member, 2021-2023), 17-07585Y (team member, 2020), DZRO-ZHN-2017 (team member, 2017-2021), CZ.02.1.01/0.0/0.0.18_069/0010046 (team member, 2019-2022), CZ.02.1.01/0.0/0.0.18_069/0010054 (team member, 2019-2022),

 

Further extracurricular activities

2017–2019

appointed as an evaluator in the National accreditation authority for the higher education in Czech Republic; field Pharmacy

2019

National finalist in FameLab 2019 (British Council) and Falling Walls Lab 2019 (German Embassy)

2021

CBRNE trainer of chemical weapons of mass destruction countermeasure

2022

invited lecture under terms of science popularization by Kampus Hybernska, the tittle “Dark side of science” (https://youtu.be/hSDuRSH72yU - Czech language) 

2022 invited lecture under terms of science popularization by pharmaceutical company Contipro a.s., the tittle “Cancer – what we know and how to use it for the treatment”

 

 

Awards

2018

Faculty of Military Health Sciences Dean’s award for scientific contribution in 2018 

 

Publication acitivity

Author or co‑author 28 scientific publications with IF

H-Index: 12 (WoS)

Citations without autocitations: 385

(dated 03/2023)

 

Selected publications in last five years

(1)       Gorecki, L.; Soukup, O.; Korabecny, J. Countermeasures in Organophosphorus Intoxication: Pitfalls and Prospects. Trends Pharmacol. Sci. 2022, 43 (7), 593–606. https://doi.org/10.1016/j.tips.2022.04.008. IF2021 = 17.638 (first author)

(2)       Gorecki, L.; Muthna, D.; Merdita, S.; Andrs, M.; Kucera, T.; Havelek, R.; Muckova, L.; Kobrlova, T.; Soukup, J.; Krupa, P.; Prchal, L.; Soukup, O.; Roh, J.; Rezacova, M.; Korabecny, J. 7-Azaindole, 2,7-Diazaindole, and 1H-Pyrazole as Core Structures for Novel Anticancer Agents with Potential Chemosensitizing Properties. Eur. J. Med. Chem. 2022, 240, 114580. https://doi.org/10.1016/j.ejmech.2022.114580. IF2021 = 7.088 (first author)

(3)       Gorecki, L.; Andrs, M.; Korabecny, J. Clinical Candidates Targeting the ATR–CHK1–WEE1 Axis in Cancer. Cancers 2021, 13 (4), 795. https://doi.org/10.3390/cancers13040795. IF2021 = 6.575 (first author)

(4)       Gorecki, L.; Uliassi, E.; Bartolini, M.; Janockova, J.; Hrabinova, M.; Hepnarova, V.; Prchal, L.; Muckova, L.; Pejchal, J.; Karasova, J. Z.; Mezeiova, E.; Benkova, M.; Kobrlova, T.; Soukup, O.; Petralla, S.; Monti, B.; Korabecny, J.; Bolognesi, M. L. Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer’s Disease. ACS Chem. Neurosci. 2021, 12 (9), 1698–1715. https://doi.org/10.1021/acschemneuro.1c00184. IF2021 = 5.780 (first author)

(5)       Gorecki, L.; Misiachna, A.; Damborsky, J.; Dolezal, R.; Korabecny, J.; Cejkova, L.; Hakenova, K.; Chvojkova, M.; Karasova, J. Z.; Prchal, L.; Novak, M.; Kolcheva, M.; Kortus, S.; Vales, K.; Horak, M.; Soukup, O. Structure-Activity Relationships of Dually-Acting Acetylcholinesterase Inhibitors Derived from Tacrine on N-Methyl-d-Aspartate Receptors. Eur. J. Med. Chem. 2021, 219, 113434. https://doi.org/10.1016/j.ejmech.2021.113434. IF2021 = 7.088 (first author)

(6)       Gorecki, L.; Andrs, M.; Rezacova, M.; Korabecny, J. Discovery of ATR Kinase Inhibitor Berzosertib (VX-970, M6620): Clinical Candidate for Cancer Therapy. Pharmacol. Ther. 2020, 107518. https://doi.org/10.1016/j.pharmthera.2020.107518. IF2020 = 12.31 (first author)

(7)       Gorecki, L.; Gerlits, O.; Kong, X.; Cheng, X.; Blumenthal, D. K.; Taylor, P.; Ballatore, C.; Kovalevsky, A.; Radić, Z. Rational Design, Synthesis, and Evaluation of Uncharged, “Smart” Bis-Oxime Antidotes of Organophosphate-Inhibited Human Acetylcholinesterase. J. Biol. Chem. 2020, 295 (13), 4079–4092. https://doi.org/10.1074/jbc.RA119.012400. IF2020 = 5.157 (first author)

(8)       Namasivayam, V.; Stefan, K.; Gorecki, L.; Korabecny, J.; Soukup, O.; Jansson, P. J.; Pahnke, J.; Stefan, S. M. Physicochemistry Shapes Bioactivity Landscape of Pan-ABC Transporter Modulators: Anchor Point for Innovative Alzheimer’s Disease Therapeutics. Int. J. Biol. Macromol. 2022, 217, 775–791. https://doi.org/10.1016/j.ijbiomac.2022.07.062. IF2021 = 8.025 (co-author)

(9)       Gorecki, L.; Hepnarova, V.; Karasova, J. Z.; Hrabinova, M.; Courageux, C.; Dias, J.; Kucera, T.; Kobrlova, T.; Muckova, L.; Prchal, L.; Malinak, D.; Jun, D.; Musilek, K.; Worek, F.; Nachon, F.; Soukup, O.; Korabecny, J. Development of Versatile and Potent Monoquaternary Reactivators of Acetylcholinesterase. Arch. Toxicol. 2021, 95 (3), 985–1001. https://doi.org/10.1007/s00204-021-02981-w. IF2021 = 5.153 (first author)

(10)     Gorecki, L.; Soukup, O.; Kucera, T.; Malinak, D.; Jun, D.; Kuca, K.; Musilek, K.; Korabecny, J. Oxime K203: A Drug Candidate for the Treatment of Tabun Intoxication. Arch. Toxicol. 2019, 93 (3), 673–691. https://doi.org/10.1007/s00204-018-2377-7. IF2019 = 5.059 (first author)

 

 


  • Introduction
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    • Andrš Martin
    • Benek Ondřej
    • Benková Markéta
    • Doležal Rafael
    • Fabrik Ivo
    • Fabriková Daniela
    • Finger Vladimír
    • Górecki Lukáš
    • Hatlapatková Jana
    • Hrabinová Martina
    • Hympánová Michaela
    • Janoušek Jiří
    • Kobrlová Tereza
    • Konečný Jan
    • Korábečný Jan
    • Kuča Kamil
    • Kupčík Rudolf
    • Lenčo Juraj
    • Maliňák Dávid
    • Marek Jan
    • Marková Aneta
    • Mezeiová Eva
    • Múčková Ľubica
    • Musílek Kamil
    • Novák Martin
    • Prchal Lukáš
    • Psotka Miroslav
    • Pulkrábková Lenka
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    • Svobodová Barbora
    • Tichý Aleš
    • Vajrychová Marie
    • Vaňousová Andrea
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