Mezeiová Eva | Centrum biomedicínského výzkumu

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Mezeiová Eva

Info

For Czech version click here

Postdoctoral fellow
+421 915 367 634
eva.mezeiova@gmail.com
ORCID: 0000-0002-9986-5017


Education

Ph.D. 2015

Pavol Jozef Safarik University in Kosice, Faculty of Science
Disertation thesis: Convergent stereoselective synthesis of jaspine B and its stereoizomers

RNDr. 2013

Pavol Jozef Safarik University in Kosice, Faculty of Science
Title of thesis: [3,3]-Heterosigmatropicre arrangements as key reactions in stereoselective synthesis of (-)-jaspine B and its C(4)-epimer

Mgr. 2011

Pavol Jozef Safarik University in Kosice, Faculty of Science
Diploma thesis: Stereoselective synthesis of (5S)-5-deoxy-1,2-O-isopropylidene-5-C-methyl-β-l-lyxo-hexafuranose as a precursor molecule of (+)-lactacystin

 

Professional Training

Since 2015 Postdoctoral fellow, Biomedical Research Centre, University Hospital Hradec Kralove

Since 2017 Research fellow, National Institute of Mental Health, Klecany

 

Projects

VVGS 27/12-13, Total synthesis of compounds with sphingoid structure using aza-Claisen rearrangement as key step, team-member

VVGS-PF-2013-117, Total synthesis of jaspine B, 4-epi-jaspine B and D-treo-sfinganine using [3,3]-sigmatropic rearrangements, main investigator

VEGA 1/0398/14, Asymmetric organocatalyzed [3,3]-sigmatropic rearrangements for the synthesis of salinosporamides and cinnabaramide A, team-member

VEGA 1/0168/15, Stereoconvergent total synthesis of broussonetines and their analogues using heterosigmatropic rearrangements, team-member

AZV 15-30954A, Development of multi-target drugs for Alzheimer’s disease: combination of AChE inhibitor and melatonin derivative, team-member

IG FNHK 2016, N-propargyl-naphtoquinone hybrids: New disease-modifying agents for Alzheimer’s disease, team-member

IG FNHK 2016, Development of insecticides as acetylcholinesterase inhibitors, team-member

IG FNHK 2017, Development of squaric acid derivatives as novel potential therapeutics for Alzheimer’s disease, main investigator

GACR 17-13541S, Development of novel radio protective agents based on small molecule inhibitors, team-member

GACR 17-07585Y, Effect of cholinesterase inhibitors on monoaminergic system and energy metabolism, team-member

GACR 17-08596S, Novel Therapeutic approaches in narcolepsy, team-member

 

Student supervising

Since 2011 supervisor of 1 bachelor thesis, consultant of 5 master thesis 

 

Publication activity

Author or co-author of 12 scientific publications in journals with  IF (3x 1. autor)

H-index: 4

Citations without autocitations: 55

(dated 5/2018)

 

Selected publications

Mezeiova, E.; Spilovska, K.; Nepovimova, E.; Gorecki, L.; Soukup, O.; Dolezal, R.; Malinak, D.; Janockova, J.; Jun, D.; Kuca, K.; Korabecny, J. Profiling donepezil template into multipotent hybrids with antioxidant properties. J. Enzym Inhib. Med. Chem. 2018, 33, 583–606. DOI: 0.1080/14756366.2018.1443326. IF2016 = 4.293

Korabecny, J.; Nepovimova, E.; Cikankova, T.; Spilovska, K.; Vaskova, L.; Mezeiova, E.; Kuca, K.; Hroudova, J. Newly Developed Drugs for Alzheimer’s Disease in Relation of Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission. Neuroscience 2018, 370, 191–206. DOI: 10.1016/j.neuroscience.2017.06.034. IF2016 = 3.277

Mezeiova, E.; Korabecny, J.; Sepsova, V.; Hrabinova, M.; Jost, P.; Muckova, L.; Kucera, T.; Dolezal, T.; Misik, J.; Spilovska, K.; Pham, NL, Pokrievkova, L.; Roh, J.; Jun, D.; Soukup, O.; Kaping, D.; Kuca, K. Development of 2-Methoxyhuprine as Novel Lead for Alzheimer’s Disease Therapy. Molecules 2017, 22, 1265. DOI: 10.3390/molecules22081265. IF2016 = 2.861

Korabecny, J.; Andrs, M.; Nepovimova, E.; Dolezal, R.; Babkova, K.; Horova, A.; Malinak, D.; Mezeiova, E.; Sepsova, V.; Hrabinova, M.; Soukup, O.; Jun, D.; Kuca, K. 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment. Molecules 2015, 20, 22084-22101. DOI: 10.3390/molecules201219836. IF2015 = 2.465

Martinkova, M.; Mezeiova, E.; Gonda, J.; Jaskova, D.; Pomikalova, K. Total synthesis of (-)-jaspine B and its 4-epi-analogue from D-xylose. Tetrahedron: Asymmetry 2014, 25, 750-766. DOI: 10.1016/j.tetasy.2014.04.002. IF2014 = 2.155


  • Introduction
  • Our team
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    • Andrš Martin
    • Benek Ondřej
    • Benková Markéta
    • Doležal Rafael
    • Fabrik Ivo
    • Fabriková Daniela
    • Finger Vladimír
    • Górecki Lukáš
    • Hatlapatková Jana
    • Hrabinová Martina
    • Hympánová Michaela
    • Janoušek Jiří
    • Kobrlová Tereza
    • Konečný Jan
    • Korábečný Jan
    • Kuča Kamil
    • Kupčík Rudolf
    • Lenčo Juraj
    • Maliňák Dávid
    • Marek Jan
    • Marková Aneta
    • Mezeiová Eva
    • Múčková Ľubica
    • Musílek Kamil
    • Novák Martin
    • Prchal Lukáš
    • Psotka Miroslav
    • Pulkrábková Lenka
    • Schmidt Monika
    • Soukup Ondřej
    • Svobodová Barbora
    • Tichý Aleš
    • Vajrychová Marie
    • Vaňousová Andrea
    • Živná Natálie
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