Hrabinová Martina

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Postdoctoral fellow
hrabinovamartina@gmail.com
ORCID:0000-0002-9428-4109

Martina obtained her Master degree in 2014 in the study program Medical bioanalytics at the Faculty of Pharmacy in Hradec Kralove, Charles University in Prague. Currently, Martina is a student of doctoral degree program Toxicology at the Faculty of Military Health Sciences in Hradec Kralove, University of Defence in Brno, and simultaneously she works as a researcher at the Biomedical Research Center and as academic employee at Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence in Brno.

Education

Professional Training 

Publication activity

Author or co-author 72 scientific publications with IF

Citation: 660 (excluding self-citations)

H-index: 17

Selected publications

2019

Svobodova B, Mezeiova E, Hepnarova V, Hrabinova M, Muckova L, Kobrlova T, Jun D, Soukup O, Jimeno ML, Marco-Contelles J, Korabecny J. Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors. Biomolecules. 2019 Aug 19;9(8). pii: E379. doi: 10.3390/biom9080379.

Kohelová E, Peřinová R, Maafi N, Korábečný J, Hulcová D, Maříková J, Kučera T, Martínez González L, Hrabinova M, Vorčáková K, Nováková L, De Simone A, Havelek R, Cahlíková L. Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer's Disease. Molecules. 2019 Apr 3;24(7). pii: E1307. doi: 10.3390/molecules24071307.

Hepnarova V, Muckova L, Ring A, Pejchal J, Herman D, Misik J, Hrabinova M, Jun D, Soukup O. Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators. Toxicol Appl Pharmacol. 2019 Nov 15;383:114776. doi: 10.1016/j.taap.2019.114776.

2018

Kuca K, Jun D, Junova L, Musilek K, Hrabinova M, da Silva JAV, Ramalho TC, Valko M, Wu Q, Nepovimova E, França TCC. Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon. Molecules.  2018 May 7;23(5). pii: E1103. doi: 10.3390/molecules23051103.

Kuca K, Musilek K, Jun D, Zdarova-Karasova J, Nepovimova E, Soukup O, Hrabinova M, Mikler J, Franca TCC, Da Cunha EFF, De Castro AA, Valis M, Ramalho TC. A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase. BMC Pharmacol Toxicol. 2018 Feb 21;19(1):8. doi: 10.1186/s40360-018-0196-3.

Šafratová M, Hošťálková A, Hulcová D, Breiterová K, Hrabcová V, Machado M, Fontinha D, Prudêncio M, Kuneš J, Chlebek J, Jun D, Hrabinová M, Nováková L, Havelek R, Seifrtová M, Opletal L, Cahlíková L. Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity. Arch Pharm Res. 2018 Feb;41(2):208-218. doi: 10.1007/s12272-017-1000-4. 

2017

Mezeiova E, Korabecny J, Sepsova V, Hrabinova M, Jost P, Muckova L, Kucera T, Dolezal R, Misik J, Spilovska K, Pham NL, Pokrievkova L, Roh J, Jun D, Soukup O, Kaping D, Kuca K. Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy. Molecules. 2017 Jul 28;22(8). pii: E1265. doi: 10.3390/molecules22081265. 

Jeřábek J, Uliassi E, Guidotti L, Korábečný J, Soukup O, Sepsova V, Hrabinova M, Kuča K, Bartolini M, Peña-Altamira LE, Petralla S, Monti B, Roberti M, Bolognesi ML. Tacrine-resveratrol fused hybrids as multi-target-directed ligands  against Alzheimer's disease. Eur J Med Chem. 2017 Feb 15;127:250-262. Doi 10.1016/j.ejmech.2016.12.048.

2016

Hamulakova S, Poprac P, Jomova K, Brezova V, Lauro P, Drostinova L, Jun D, Sepsova V, Hrabinova M, Soukup O, Kristian P, Gazova Z, Bednarikova Z, Kuca K, Valko M. Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules. J Inorg Biochem. 2016 Aug;161:52-62. doi:10.1016/j.jinorgbio.2016.05.001.