Kuča Kamil

Info KK aj

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+420 495 833 447
kamil.kuca@fnhk.cz
ORCID: 0000-0001-9664-1109
Scopus ID: 9745735500
ResID: D-1396-2011


Kamil obtained his Profesorship in 2012 at the Faculty of Military health Sciences (University of Defence, Czech Republic). Currently, as a rector of the University of Hradec Kralove. He is working at the Biomedical Research Center (BRC), University Hospital Hradec Kralove, as senior researcher. He is responsible for the development of new drugs, toxicology and heath economy. Besides the scientific activity, Kamil is devoted to the postdocs and students supervising, teaching and science management.

Education

2012 Professor – Toxicology – Faculty of Military Health Sciences, University of Defense, Hradec Kralove (Czech Republic)
2009 Associate Professor – Toxicology – Faculty of Military Health Sciences, University of Defense, Hradec Kralove (Czech Republic)
2005 PhD. – Toxicology – Department of Toxicology, Faculty of Military Health Sciences, University of Defense, Hradec Kralove (Czech Republic)
2001 MSc. – Organic Chemistry – Department of Organic Chemistry, Faculty of Chemical Technology, Institute of Chemical Technology, Prague (Czech Republic)

Research Focus

Development of novel drugs; Toxicology; Health Economy and Pharmacoeconomy; Chemical warfare agents; IT in Bioscience

Professional Training

2018–today Senior researcher, Center for Biomedical Sciences, University Hospital, Hradec Kralove (Czech Republic)
2016–today Rector of the University of Hradec Kralove
2015–2016 Vice-Rector for Research of the University of Hradec Kralove
2014–2016 Technology Scout, University of Hradec Kralove
2013–today Professor, Research and Development, Faculty of Informatics and Management, University of Hradec Kralove
2013–today Professor, Research and Development, Faculty of Science, University Hradec Kralove
2012–2017 Head of the department, Center for Biomedical Sciences, University Hospital, Hradec Kralove (Czech Republic)
2011–2014 Head of the department, Center for Transfer of Biomedical Technologies, University Hospital, Hradec Kralove (Czech Republic)
2010–2012 Vice-Dean for Science, Faculty of Military Health Sciences, University of Defense, Hradec Kralove (Czech Republic)
2006–2012 Lecturer, Department of Chemistry, Faculty of Sciences, J. E. Purkinje University, Usti nad Labem (Czech Republic)
2006–2010 Research and Development, Centre of Advanced Studies, Faculty of Military Health Sciences, University of Defense, Hradec Kralove (Czech Republic)
2002–2006 Research and Development, Department of Toxicology, Faculty of Military Health Sciences, University of Defense, Hradec Kralove (Czech Republic)

 

Editorial Boards

  • Military Medical Science Letters (FVZ UO)
  • Medicinal Chemistry (Bentham)
  • Letters in Drug Design Discovery (Bentham, Editor-in-chief)
  • Letters in Organic Chemistry (Bentham)
  • Mini-Reviews Medicinal Chemistry (Bentham)
  • Notulae Botanicae Horti Agrobotanici Cluj-Napoca (AcademicPres)
  • Drug and Chemical Toxicology  (Taylor&Francis)
  • Food Chemical Toxicology (Elsevier)
  • Environmental Toxicology and Pharmacology (Elsevier)
  • International Journal of Molecular Sciences (MDPI)
  • Molecules (MDPI)
  • Vaccines (MDPI)
  • Journal of Applied Biomedicine (Elsevier)
  • Frontiers in Chemistry

 

Projects

Title: Smart biocompatable nanotools to selectively deliver drug-siRNA cocktails for combination breast cancer therapy
Funding: Czech Ministry of Health NU20-03-00477
Schedule: 2020–2023
Role: principal investigator
Title:

Evaluation of investments in medical device development
Funding: Czech Science Foundation GA17-03037S
Schedule: 2017–2019
Role: team member
Title: Localised electronic antibody binding effects on nanocomposite materials (LEEFAB)
Funding: Czech Science Foundation GA17-19968S
Schedule: 2017-2019
Role: co-investigator
Title:

Developing a multifunctional drug for Alzheimer's disease: combination of an AChE inhibitor and a melatonin derivative
Funding: Czech Ministry of Health NV15-30954A
Schedule: 2015–2019
Role: principal investigator
Title:

Plasmonic nanoparticles for teranostics with adjustable optoteral parameters
Funding: Czech Ministry of Health NV15-30954A
Schedule: 2016–2018
Role: principal investigator

 

Title: Centre of Biomedical Technologies Transfer in HK
Funding:

Ministry of Education, Youth and Sports ED3.2.00/10.0213
Schedule: 2012–2015
Role: principal investigator
Title: Relationship between structure of acetylcholinesterase reactivators and their reactivation potency
Funding: Czech Science Foundation GP305/07/P162
Schedule: 2007–2009
Role: principal investigator
Title: Countermeasure against chemical terrorism – development of new antidotes against nerve agents
Funding: Ministry of Education, Youth and Sports ME 865
Schedule: 2006–2009
Role: principal investigator
Title: The Evaluation of Penetration of Different Acetylcholinesterase Reactivators through Blood–Brain Barrier
Funding: Ministry of Health NS9748
Schedule: 2009–2010
Role: other investigator
Title: Preparation and biological evaluation of new therapeutics against to pesticides
Funding: Ministry of Health NT12062
Schedule: 2011–2014
Role: principal investigator
Title: A new method of prophylaxis, decontamination, diagnostics and therapy afer intoxication with nerve agents and yperits
Funding: Ministry of Defence OPUOFVZ200603
Schedule: 2006–2008
Role: other investigator
Title: Robotized system for in vitro evaluation of novel rectivators of acetylcholinesterase inhibited by nerve agents
Funding: Ministry of Defence OVUOFVZ200801
Schedule: 2008–2011
Role: other investigator
Title: Development of novel decontaminants and disinfectants of skin based on micellar compounds
Funding: Ministry of Defence OVUOFVZ200803
Schedule: 2008–2011
Role: principal investigator
Title: Novel inhibitors of acetylcholinesterase as prophylaxis of nerve agent poisonings
Funding: Ministry of Defence OVUOFVZ200805
Schedule: 2008–2011
Role: other investigator
Title: Biosensors for determination of nerve agents and yperites using recombinant proteins and nanotechnology
Funding: Ministry of Defence OVUOFVZ200807
Schedule: 2008–2011
Role: other investigator
Title: Determination of important pharmacokinetic and biochemical parameters and evaluation of blood-brain barrier penetration using drugs introduced to Czech Army
Funding: Ministry of Defence OVUOFVZ200811
Schedule: 2008–2011
Role: other investigator
Title: Novel prophylactic antidotes of nerve agent poisonings based on scavengers
Funding: Ministry of Defence OVUOFVZ200902
Schedule: 2009–2012
Role: other investigator
Title: Influence of the nerve agent and reactivators of Acetyl Choline Esterase on the Guinea Pig
Funding: Ministry of Defence OVUOFVZ200905
Schedule: 2009–2011
Role: other investigator
Title: Medical countermeasures of nuclear, biological and chemical casualties (Institutional Research Plans)
Funding: Ministry of Defence MO0FVZ0000501
Schedule: 2005–2011
Role: other investigator
Title: Information support of crises management in health care (Institutional Research Plans)
Funding: Ministry of Defence
Schedule: 2006–2011
Role: principal investigator

 

Cooperation

  • Institute for Medical Research and Occupational Health, Zagreb
  • Korean Research Institute of Chemical Technology, Daejon, Korea
  • Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
  • Military Institute of Engineering, Rio de Janeiro, Brazil
  • Department of Chemistry, Federal University of Lavras, Lavras, Brazil
  • School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur (C.G.), India
  • School of Biology, University of St. Andrews, Medical and Biological Sciences, St. Andrews, UK
  • Florida International University, Miami, USA
  • College of Life Science, Yangtze University, China
  • University P. J. Safarika in Kosice, Department of Chemistry, Slovakia


Publication activity

  • Author or co-author of more than 500 original or review articles with IF
  • Author or co-author of more than 20 book chapters
  • H-index: over 50

(dated 5/2021)

 

Selected publications 

2021

ALGHUTHAYMI, Mousa A. - RAJKUBERAN, C. - RAJIV, P. - KALIA, Anu - BHARDWAJ, Kanchan - BHARDWAJ, Prerna - ABD-ELSALAM, Kamel A. - VALIŠ, Martin - KUČA, Kamil. Nanohybrid Antifungals for Control of Plant Diseases: Current Status and Future Perspectives. Journal of Fungi [online], 2021, 7(1), Art. No. 48. ISSN 2309-608X. DOI: 10.3390/jof7010048.

PATOČKA, Jiří - WU, Ran - NEPOVIMOVA, Eugenie - VALIŠ, Martin - WU, Wenda - KUČA, Kamil. Chemistry and Toxicology of Major Bioactive Substances in Inocybe Mushrooms. International Journal of Molecular Sciences [online], 2021, 22(4), Art. No. 2218. ISSN 1422-0067. DOI: 10.3390/ijms22042218.

LEONEL JAVERES, Mbah Ntepe - HABIB, Rabia - JUDITH LAURE, Ngondi - ABBAS SHAH, Syed Tahir - VALIŠ, Martin - KUČA, Kamil - MUHAMMAD NURULAIN, Syed. Chronic Exposure to Organophosphates Pesticides and Risk of Metabolic Disorder in Cohort from Pakistan and Cameroon. International Journal of Environmental Research and Public Health, 2021, 18(5), Art. No. 2310. ISSN 1661-7827. DOI: 10.3390/ijerph18052310.

HONS, Jaromír - ŽIRKO, Rastislav - VAŠATOVÁ, Martina - DOUBEK, Pavel - FRYDRYCHOVÁ KLÍMOVÁ, Blanka - MASOPUST, Jiří - VALIŠ, Martin - KUČA, Kamil. Impairment of Executive Functions Associated With Lower D-Serine Serum Levels in Patients With Schizophrenia. Frontiers in Psychiatry [online], 2021, 12(MAR), Art. No. 514579. ISSN 1664-0640. DOI: 10.3389/fpsyt.2021.514579.

ALI, Aaliya - GARG, Prakrati - GOYAL, Rohit - KAUR, Gurjot - LI, Xiangkai - NEGI, Poonam - VALIŠ, Martin - KUČA, Kamil - KULSHRESTHA, Saurabh. A Novel Herbal Hydrogel Formulation of Moringa oleifera for Wound Healing. Plants [online], 2021, 10(1), Art. No. 25. ISSN 2223-7747. DOI: 10.3390/plants10010025.

 

2020

PATOČKA, Jiří - WU, Qinghua - NEPOVIMOVÁ, Eugenie - KUČA, Kamil. Phenytoin - An anti-seizure drug: Overview of its chemistry, pharmacology and toxicology. Food and Chemical Toxicology, 2020, 142(AUG), Art. No. 111393. ISSN 0278-6915. DOI: 10.1016/j.fct.2020.111393.

MALIŇÁK, Dávid - DOLEŽAL, Rafael - HEPNAROVÁ, Vendula - HOZOVÁ, Miroslava - ANDRÝS, Rudolf - BZONEK, Petr - RAČÁKOVÁ, Veronika - KORÁBEČNÝ, Jan - GÓRECKI, Lukáš - MEZEIOVÁ, Eva - PSOTKA, Miroslav - JUN, Daniel - KUČA, Kamil - MUSÍLEK, Kamil. Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators. Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35(1), 478-488. ISSN 1475-6366. DOI: 10.1080/14756366.2019.1710501.

DE CASTRO, Alexandre A. - POLISEL, Daniel A. - PEREIRA, Bruna T. L. - DA CUNHA, Elaine F. F. - KUČA, Kamil - NEPOVIMOVA, Eugenie - RAMALHO, Teodorico C.. Understanding the interaction modes and reactivity of trimedoxime towardMmAChE inhibited by nerve agents: Theoretical and experimental aspects. International Journal of Molecular Sciences [online], 2020, 21(18), Art. No. 6510. ISSN 1422-0067. DOI: 10.3390/ijms21186510.

NEZIC, Lana - SKRBIC, Ranko - AMIDZIC, Ljiljana - GAJANIN, Radoslav - MILOVANOVIC, Zoran - NEPOVIMOVA, Eugenie - KUČA, Kamil - JACEVIC, Vesna. Protective effects of simvastatin on endotoxin-induced acute kidney injury through activation of tubular epithelial cells' survival and hindering cytochrome C-Mediated apoptosis. International Journal of Molecular Sciences [online], 2020, 21(19), Art. No. 7236. ISSN 1422-0067. DOI: 10.3390/ijms21197236.

PATOČKA, Jiří - ZHAO, Bingshu - WU, Wenda - KLÍMOVÁ, Blanka - VALIŠ, Martin - NEPOVIMOVA, Eugenie - KUČA, Kamil. Flakka: New dangerous synthetic cathinone on the drug scene. International Journal of Molecular Sciences [online], 2020, 21(21), Art. No. 8185. ISSN 1422-0067. DOI: 10.3390/ijms21218185.


2019

NEPOVIMOVÁ, Eugenie - JANOČKOVÁ, Jana - MISÍK, Jan - KUBIK, Stěpán - STUCHLÍK, Aleš - VALEŠ, Karel - KORÁBEČNÝ, Jan - MEZEIOVÁ, Eva - DOLEŽAL, Rafael - SOUKUP, Ondřej - KOBRLOVÁ, Tereza - PHAM, Ngoc Lam - NGUYEN, Thuy Duong - KONEČNÝ, Jan - KUČA, Kamil. Orexin supplementation in narcolepsy treatment: A review. Medicinal Research Reviews, 2019, 39(3), 961-975. ISSN 0198-6325. DOI: 10.1002/med.21550. IF=9.300

CHALUPOVÁ, Katarína - KORÁBEČNÝ, Jan - BARTOLINI, Manuela - MONTI, Barbara - LAMBA, Doriano - CALIANDRO, Rosanna - PESARESI, Alessandro - BRAZZOLOTTO, Xavier - GASTELLIER, Anne-Julie - NACHON, Florian - PEJCHAL, Jaroslav - JAROŠOVÁ, Michaela - HEPNAROVÁ, Vendula - JUN, Daniel - HRABINOVÁ, Martina - DOLEŽAL, Rafael - ŽĎÁROVÁ KARASOVÁ, Jana - MŽIK, Martin - KRIŠTOFIKOVÁ, Zdena - MISÍK, Jan - MÚČKOVÁ, Ľubica - JOŠT, Petr - SOUKUP, Ondřej - BENKOVÁ, Markéta - SETNIČKA, Vladimír - HABARTOVÁ, Lucie - CHVOJKOVÁ, Markéta - KLETEČKOVÁ, Lenka - VALEŠ, Karel - MEZEIOVÁ, Eva - ULIASSI, Elisa - VALIŠ, Martin - NEPOVIMOVÁ, Eugenie - BOLOGNESI, Maria Laura - KUČA, Kamil. Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease. European Journal of Medicinal Chemistry, 2019, 168(April), 491-514. ISSN 0223-5234. DOI: 10.1016/j.ejmech.2019.02.021. IF=5.573

GÓRECKI, Lukáš - SOUKUP, Ondřej - KUCERA, Tomas - MALIŇÁK, Dávid - JUN, Daniel - KUČA, Kamil - MUSÍLEK, Kamil - KORÁBEČNÝ, Jan. Oxime K203: a drug candidate for the treatment of tabun intoxication. Archives of Toxicology, 2019, 93(3), 673-691. ISSN 0340-5761. DOI: 10.1007/s00204-018-2377-7. IF=5.059

JANOČKOVÁ, Jana - KORÁBEČNÝ, Jan - PLSIKOVA, Jana - BABKOVÁ, Kateřina - KONKOLOVA, Eva - KUCEROVA, Dana - VARGOVA, Jana - KOVAL, Jan - JENDZELOVSKY, Rastislav - FEDOROCKO, Peter - KASPARKOVA, Jana - BRABEC, Viktor - ROSOCHA, Jan - SOUKUP, Ondřej - HAMULAKOVA, Slavka - KUČA, Kamil - KOŽURKOVÁ, Mária. In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers. Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34(1), 877-897. ISSN 1475-6366. DOI: 10.1080/14756366.2019.1593159. IF=4.673

SALES, Thais A. - PRANDI, Ingrid G. - DE CASTRO, Alexandre A. - LEAL, Daniel H. S. - DA CUNHA, Elaine F. F. - KUČA, Kamil - RAMALHO, Teodorico C.. Recent developments in metal-based drugs and chelating agents for neurodegenerative diseases treatments. International Journal of Molecular Sciences, 2019, 20(8), Art. No. 1829. ISSN 1422-0067. DOI: 10.3390/ijms20081829. IF=4.556

 

2018

BENEK, Ondřej - HROCH, Lukáš - AITKEN, Laura - GUNN-MOORE, Frank - VINKLÁŘOVÁ, Lucie - KUČA, Kamil - PEREZ, Daniel I. - PEREZ, Concepcion - MARTINEZ, Ana - FIŠAR, Zdeněk - MUSÍLEK, Kamil. 1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders. Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 33(1), 665-670. ISSN 1475-6366. DOI: 10.1080/14756366.2018.1445736. IF=4.027

HONEGR, Jan - MALIŇÁK, Dávid - DOLEŽAL, Rafael - SOUKUP, Ondřej - BENKOVÁ, Markéta - HROCH, Lukáš - BENEK, Ondřej - JANOČKOVÁ, Jana - KUČA, Kamil - PRYMULA, Roman. Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro. European Journal of Medicinal Chemistry, 2018, 146(February), 38-46. ISSN 0223-5234. DOI: 10.1016/j.ejmech.2017.12.074. IF=4.833

KORÁBEČNÝ, Jan - NEPOVIMOVÁ, Eugenie - CIKÁNKOVÁ, Tereza - ŠPILOVSKÁ, Katarína - VAŠKOVÁ, Lucie - MEZEIOVÁ, Eva - KUČA, Kamil - HROUDOVÁ, Jana. Newly developed drugs for Alzheimer's disease in relation to energy metabolism, cholinergic and monoaminergic neurotransmission. Neuroscience, 2018, 370(February), 191-206. ISSN 0306-4522. DOI: 10.1016/j.neuroscience.2017.06.034. IF=3.244

MEZEIOVÁ, Eva - ŠPILOVSKÁ, Katarína - NEPOVIMOVÁ, Eugenie - GÓRECKI, Lukáš - SOUKUP, Ondřej - DOLEŽAL, Rafael - MALIŇÁK, Dávid - JANOČKOVÁ, Jana - JUN, Daniel - KUČA, Kamil - KORÁBEČNÝ, Jan. Profiling donepezil template into multipotent hybrids with antioxidant properties. Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 33(1), 583-606. ISSN 1475-6366. DOI: 10.1080/14756366.2018.1443326. IF=4.027

ŽÁRSKÁ, Monika - SRAMEK, Michal - NOVOTNÝ, Filip - HAVEL, Filip - BABELOVA, Andrea - MRAZKOVA, Hanka - BENADA, Oldřich - REINIS, Milan - STEPANEK, Ivan - MUSÍLEK, Kamil - BARTEK, Jiří - URSINYOVA, Monika - NOVÁK, Ondřej - DZIJAK, Rastislav - KUČA, Kamil - PROŠKA, Jan - HODNÝ, Zdeněk. Biological safety and tissue distribution of (16-mercaptohexadecyl) trimethylammonium bromide-modified cationic gold nanorods. Biomaterials, 2018, 154(February), 275-290. ISSN 0142-9612. DOI: 10.1016/j.biomaterials.2017.10.044. IF=10.273

 

2017

GAZOVA, Zuzana - SOUKUP, Ondřej - ŠEPSOVÁ, Vendula - SIPOSOVA, Katarina - DRTINOVÁ, Lucie - JOŠT, Petr - ŠPILOVSKÁ, Katarína - KORÁBEČNÝ, Jan - NEPOVIMOVÁ, Eugenie - FEDUNOVÁ, Diana - HORÁK, Martin - KANIAKOVÁ, Martina - WANG, Ze-Jun - HAMOUDA, Ayman K. - KUČA, Kamil. Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2017, 1863(2), 607-619. ISSN 0925-4439. DOI: 10.1016/j.bbadis.2016.11.020. IF=5.108

HORAK, Martin - HOLUBOVA, Kristina - NEPOVIMOVÁ, Eugenie - KRUSEK, Jan - KANIAKOVA, Martina - KORÁBEČNÝ, Jan - VYKLICKY, Ladislav - KUČA, Kamil - STUCHLIK, Ales - RICNY, Jan - VALES, Karel - SOUKUP, Ondřej. The pharmacology of tacrine at N-methyl-D-aspartate receptors. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2017, 75(April), 54-62. ISSN 0278-5846. DOI: 10.1016/j.pnpbp.2017.01.003. IF=4.185

JEŘÁBEK, Jakub - ULIASSI, Elisa - GUIDOTTI, Laura - KORÁBEČNÝ, Jan - SOUKUP, Ondřej - ŠEPSOVÁ, Vendula - HRABINOVÁ, Martina - KUČA, Kamil - BARTOLINI, Manuela - PENA-ALTAMIRA, Luis Emiliano - PETRALLA, Sabrina - MONTI, Barbara - ROBERTI, Marinella - BOLOGNESI, Maria Laura. Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease. European Journal of Medicinal Chemistry, 2017, 127(February), 250-262. ISSN 0223-5234. DOI: 10.1016/j.ejmech.2016.12.048. IF=4.816

ŽĎÁROVÁ KARASOVÁ, Jana - MADERYCOVÁ, Zuzana - TŮMOVÁ, Martina - JUN, Daniel - ŘEHÁČEK, Vít - KUČA, Kamil - MISÍK, Jan. Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis. Toxicology Letters, 2017, 277(August), 24-31. ISSN 0378-4274. DOI: 10.1016/j.toxlet.2017.04.017. IF=3.166

ŽĎÁROVÁ KARASOVÁ, Jana - KVĚTINA, Jaroslav - TACHECÍ, Ilja - RADOCHOVÁ, Věra - MUSÍLEK, Kamil - KUČA, Kamil - BUREŠ, Jan. Pharmacokinetic profile of promising acetylcholinesterase reactivators K027 and K203 in experimental pigs. Toxicology Letters, 2017, 273(May), 20-25. ISSN 0378-4274. DOI: 10.1016/j.toxlet.2017.03.017. IF=3.166

 

2016

GÓRECKI, Lukáš - KORÁBEČNÝ, Jan - MUSÍLEK, Kamil - MALIŇÁK, Dávid - NEPOVIMOVÁ, Eugenie - DOLEŽAL, Rafael - JUN, Daniel - SOUKUP, Ondřej - KUČA, Kamil. SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides. Archives of Toxicology, 2016, 90(12), 2831-2859. ISSN 0340-5761. DOI: 10.1007/s00204-016-1827-3. IF=5.901

SHARMA, Rahul - GUPTA, Bhanushree - YADAV, Toshikee - SINHA, Srishti - SAHU, Arvind Kumar - KARPICHEV, Yevgen - GATHERGOOD, Nicholas - MAREK, Jan - KUČA, Kamil - GHOSH, Kallol K.. Degradation of organophosphate pesticides using pyridinium based functional surfactants. ACS Sustainable Chemistry & Engineering, 2016, 4(12), 6962-6973. ISSN 2168-0485. DOI: 10.1021/acssuschemeng.6b01878. IF=5.951

VALKO, Marian - JOMOVA, Klaudia - RHODES, Christoper J. - KUČA, Kamil - MUSÍLEK, Kamil. Redox- and non-redox metal induced formation of free radicals and their role in human disease. Archives of Toxicology, 2016, 90(1), 1-37. ISSN 0340-5761. DOI: 10.1007/s00204-015-1579-5. IF=5.901

WU, Qinghua - LIU, Lian - MIRON, Anca - KLÍMOVÁ, Blanka - WAN, Dan - KUČA, Kamil. The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview. Archives of Toxicology, 2016, 90(8), 1817-1840. ISSN 0340-5761. DOI: 10.1007/s00204-016-1744-5. IF=5.901

ŽÁRSKÁ, Monika - NOVOTNÝ, Filip - HAVEL, Filip - ŠRÁMEK, Michal - BÁBELOVÁ, Andrea - BENADA, Oldřich - NOVOTNÝ, Michal - SARAN, Hilal - KUČA, Kamil - MUSÍLEK, Kamil - HVĚZDOVÁ, Zuzana - DZIJAK, Rastislav - VANČUROVÁ, Markéta - KREJČÍKOVÁ, Kateřina - GABAJOVÁ, Blanka - HANZLÍKOVÁ, Hana - KYJACOVÁ, Lenka - BÁRTEK, Jiří - PROSKA, Jan - HODNÝ, Zdeněk. Two-step mechanism of cellular uptake of cationic gold nanoparticles modified by (16-Mercaptohexadecyl)trimethylammonium bromide. Bioconjugate Chemistry, 2016, 27(10), 2558-2574. ISSN 1043-1802. DOI: 10.1021/acs.bioconjchem.6b00491. IF=4.818

 

2015

ANDRŠ, Martin - KORÁBEČNÝ, Jan - JUN, Daniel - HODNÝ, Zdeněk - BÁRTEK, Jiří - KUČA, Kamil. Phosphatidylinositol 3-Kinase (PI3K) and Phosphatidylinositol 3-Kinase-Related Kinase (PIKK) Inhibitors: Importance of the Morpholine Ring. Journal of Medicinal Chemistry, 2015, 58(1), 41-71. ISSN 0022-2623. DOI: 10.1021/jm501026z. IF=5.589

HORN, Gabriele - WILLE, Timo - MUSÍLEK, Kamil - KUČA, Kamil - THIERMANN, Horst - WOREK, Franz. Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase. Archives of Toxicology, 2015, 89(3), 405-414. ISSN 0340-5761. DOI: 10.1007/s00204-014-1288-5. IF=6.637

JANOČKOVÁ, Jana - PLŠÍKOVÁ, Jana - KAŠPÁRKOVÁ, Jana - BRABEC, Viktor - JENDŽELOVSKÝ, Rastislav - MIKEŠ, Jaromír - KOVAL, Ján - HAMULAKOVÁ, Slávka - FEDOROČKO, Peter - KUČA, Kamil - KOŽURKOVÁ, Mária. Inhibition of DNA topoisomerases I and II and growth inhibition of HL-60 cells by novel acridine-based compounds. European Journal of Pharmaceutical Sciences, 2015, 76(August), 192-202. ISSN 0928-0987. DOI: 10.1016/j.ejps.2015.04.023. IF=3.773

NEPOVIMOVÁ, Eugenie - KORÁBEČNÝ, Jan - DOLEŽAL, Rafael - BABKOVÁ, Kateřina - ONDŘEJÍČEK, Aleš - JUN, Daniel - ŠEPSOVÁ, Vendula - HOROVÁ, Anna - HRABINOVÁ, Martina - SOUKUP, Ondřej - BUKUM, Neslihan - JOŠT, Petr - MÚČKOVÁ, Ľubica - KASSA, Jiří - MALIŇÁK, Dávid - ANDRŠ, Martin - KUČA, Kamil. Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity. Journal of Medicinal Chemistry, 2015, 58(22), 8985-9003. ISSN 0022-2623. DOI: 10.1021/acs.jmedchem.5b01325. IF=5.589

SINGH, Namrata - KARPICHEV, Yevgen - TIWARI, Amit K. - KUČA, Kamil - GHOSH, Kallol K.. Oxime functionality in surfactant self-assembly: An overview on combating toxicity of organophosphates. Journal of Molecular Liquids, 2015, 208(August), 237-252. ISSN 0167-7322. DOI: 10.1016/j.molliq.2015.04.010. IF=2.740