+420 495 833 447
kamil.kuca@fnhk.cz
ORCID: 0000-0001-9664-1109
Scopus ID: 9745735500
ResID: D-1396-2011
Kamil obtained his Profesorship in 2012 at the Faculty of Military health Sciences (University of Defence, Czech Republic). Currently, as a rector of the University of Hradec Kralove. He is working at the Biomedical Research Center (BRC), University Hospital Hradec Kralove, as senior researcher. He is responsible for the development of new drugs, toxicology and heath economy. Besides the scientific activity, Kamil is devoted to the postdocs and students supervising, teaching and science management.
| 2012 | Professor – Toxicology – Faculty of Military Health Sciences, University of Defense, Hradec Kralove (Czech Republic) |
| 2009 | Associate Professor – Toxicology – Faculty of Military Health Sciences, University of Defense, Hradec Kralove (Czech Republic) |
| 2005 | PhD. – Toxicology – Department of Toxicology, Faculty of Military Health Sciences, University of Defense, Hradec Kralove (Czech Republic) |
| 2001 | MSc. – Organic Chemistry – Department of Organic Chemistry, Faculty of Chemical Technology, Institute of Chemical Technology, Prague (Czech Republic) |
Development of novel drugs; Toxicology; Health Economy and Pharmacoeconomy; Chemical warfare agents; IT in Bioscience
| 2018–today | Senior researcher, Center for Biomedical Sciences, University Hospital, Hradec Kralove (Czech Republic) |
| 2016–today | Rector of the University of Hradec Kralove |
| 2015–2016 | Vice-Rector for Research of the University of Hradec Kralove |
| 2014–2016 | Technology Scout, University of Hradec Kralove |
| 2013–today | Professor, Research and Development, Faculty of Informatics and Management, University of Hradec Kralove |
| 2013–today | Professor, Research and Development, Faculty of Science, University Hradec Kralove |
| 2012–2017 | Head of the department, Center for Biomedical Sciences, University Hospital, Hradec Kralove (Czech Republic) |
| 2011–2014 | Head of the department, Center for Transfer of Biomedical Technologies, University Hospital, Hradec Kralove (Czech Republic) |
| 2010–2012 | Vice-Dean for Science, Faculty of Military Health Sciences, University of Defense, Hradec Kralove (Czech Republic) |
| 2006–2012 | Lecturer, Department of Chemistry, Faculty of Sciences, J. E. Purkinje University, Usti nad Labem (Czech Republic) |
| 2006–2010 | Research and Development, Centre of Advanced Studies, Faculty of Military Health Sciences, University of Defense, Hradec Kralove (Czech Republic) |
| 2002–2006 | Research and Development, Department of Toxicology, Faculty of Military Health Sciences, University of Defense, Hradec Kralove (Czech Republic) |
| Title: |
Hodnocení investic do vývoje zdravotních prostředků |
| Funding: | Czech Science Foundation GA17-03037S |
| Schedule: | 2017–2019 |
| Role: | team member |
| Title: | Lokalizované elektronické efekty navazování protilátek na nanokompozitních materiálech (LEEFAB) |
| Funding: | Czech Science Foundation GA17-19968S |
| Schedule: | 2017-2019 |
| Role: | co-investigator |
| Title: |
Vývoj multifunkčního léčiva na Alzheimerovu nemoc: kombinace inhibitoru AChE a derivátu melatoninu |
| Funding: | Czech Ministry of health NV15-30954A |
| Schedule: | 2015–2019 |
| Role: | principal investigator |
| Title: |
Plasmonické nanočástice pro teranostiku s laditelnými optotermálními parametry |
| Funding: | Czech Ministry of health NV15-30954A |
| Schedule: | 2016–2018 |
| Role: | principal investigator |
| Title: | Centre of Biomedical Technologies Transfer in HK |
| Funding: |
Ministry of Education, Youth and Sports ED3.2.00/10.0213 |
| Schedule: | 2012–2015 |
| Role: | principal investigator |
| Title: | Relationship between structure of acetylcholinesterase reactivators and their reactivation potency |
| Funding: | Czech Science Foundation GP305/07/P162 |
| Schedule: | 2007–2009 |
| Role: | principal investigator |
| Title: | Countermeasure against chemical terrorism – development of new antidotes against nerve agents |
| Funding: | Ministry of Education, Youth and Sports ME 865 |
| Schedule: | 2006–2009 |
| Role: | principal investigator |
| Title: | The Evaluation of Penetration of Different Acetylcholinesterase Reactivators through Blood–Brain Barrier |
| Funding: | Ministry of Health NS9748 |
| Schedule: | 2009–2010 |
| Role: | other investigator |
| Title: | Preparation and biological evaluation of new therapeutics against to pesticides |
| Funding: | Ministry of Health NT12062 |
| Schedule: | 2011–2014 |
| Role: | principal investigator |
| Title: | A new method of prophylaxis, decontamination, diagnostics and therapy afer intoxication with nerve agents and yperits |
| Funding: | Ministry of Defence OPUOFVZ200603 |
| Schedule: | 2006–2008 |
| Role: | other investigator |
| Title: | Robotized system for in vitro evaluation of novel rectivators of acetylcholinesterase inhibited by nerve agents |
| Funding: | Ministry of Defence OVUOFVZ200801 |
| Schedule: | 2008–2011 |
| Role: | other investigator |
| Title: | Development of novel decontaminants and disinfectants of skin based on micellar compounds |
| Funding: | Ministry of Defence OVUOFVZ200803 |
| Schedule: | 2008–2011 |
| Role: | principal investigator |
| Title: | Novel inhibitors of acetylcholinesterase as prophylaxis of nerve agent poisonings |
| Funding: | Ministry of Defence OVUOFVZ200805 |
| Schedule: | 2008–2011 |
| Role: | other investigator |
| Title: | Biosensors for determination of nerve agents and yperites using recombinant proteins and nanotechnology |
| Funding: | Ministry of Defence OVUOFVZ200807 |
| Schedule: | 2008–2011 |
| Role: | other investigator |
| Title: | Determination of important pharmacokinetic and biochemical parameters and evaluation of blood-brain barrier penetration using drugs introduced to Czech Army |
| Funding: | Ministry of Defence OVUOFVZ200811 |
| Schedule: | 2008–2011 |
| Role: | other investigator |
| Title: | Novel prophylactic antidotes of nerve agent poisonings based on scavengers |
| Funding: | Ministry of Defence OVUOFVZ200902 |
| Schedule: | 2009–2012 |
| Role: | other investigator |
| Title: | Influence of the nerve agent and reactivators of Acetyl Choline Esterase on the Guinea Pig |
| Funding: | Ministry of Defence OVUOFVZ200905 |
| Schedule: | 2009–2011 |
| Role: | other investigator |
| Title: | Medical countermeasures of nuclear, biological and chemical casualties (Institutional Research Plans) |
| Funding: | Ministry of Defence MO0FVZ0000501 |
| Schedule: | 2005–2011 |
| Role: | other investigator |
| Title: | Information support of crises management in health care (Institutional Research Plans) |
| Funding: | Ministry of Defence |
| Schedule: | 2006–2011 |
| Role: | principal investigator |
(dated 4/2020)
Malinak D, Dolezal R, Hepnarova V, Hozova M, Andrys R, Bzonek P, Racakova V, Korabecny J, Gorecki L, Mezeiova E, Psotka M, Jun D, Kuca K, Musilek K. Synthesis, in vitro Screening and Molecular Docking of isoquinolinium-5-carbaldoximes as Acetylcholinesterase and Butyrylcholinesterase Reactivators. J Enzyme Inhib Med Chem. 2020; 35(1):478-488.
Valis M, Herman D, Vanova N, Masopust J, Vysata O, Hort J, Pavelek Z, Klimova B, Kuca K, Misik J, Zdarova Karasova J. The Concentration of Memantine in the Cerebrospinal Fluid of Alzheimer's Disease Patients and Its Consequence to Oxidative Stress Biomarkers. Front Pharmacol. 2019; 10:943.
Salajkova S, Sramek M, Malinak D, Havel F, Musilek K, Benkova M, Soukup O, Vasicova P, Prchal L, Dolezal R, Hodny Z, Bartek J, Zarska M, Kuca K. Highly Hydrophilic Cationic Gold Nanorods Stabilized by Novel Quaternary Ammonium Surfactant With Negligible Cytotoxicity. J Biophotonics. 2019; 12(12):e201900024.
Janockova J, Korabecny J, Plsikova J, Babkova K, Konkolova E, Kucerova D, Vargova J, Koval J, Jendzelovsky R, Fedorocko P, Kasparkova J, Brabec V, Rosocha J, Soukup O, Hamulakova S, Kuca K, Kozurkova M. In Vitro Investigating of Anticancer Activity of New 7-MEOTA-tacrine Heterodimers. J Enzyme Inhib Med Chem. 2019; 34(1):877-897.
Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, Dolezal R, Zdarova Karasova J, Mzik M, Kristofikova Z, Misik J, Muckova L, Jost P, Soukup O, Benkova M, Setnicka V, Habartova L, Chvojkova M, Kleteckova L, Vales K, Mezeiova E, Uliassi E, Valis M, Nepovimova E, Bolognesi ML, Kuca K. Novel Tacrine-Tryptophan Hybrids: Multi-target Directed Ligands as Potential Treatment for Alzheimer's Disease. Eur J Med Chem . 2019 Apr 15;168:491-514.
Arshad, Maria; Fatmi, Muhammad Qaiser; Musílek, Kamil; Hussain, Alamdar; Kuča, Kamil; Petroianu, Georg; Kalasz, Huba; Nurulain, Syed Muhammad: In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication. In: Toxicology Mechanisms and Methods, 2018, roč. 28, č. 1. s. 62-68. IF 1.595.
Benek, Ondřej; Hroch, Lukáš; Aitken, Laura; Gunn-Moore, Frank; Vinklářová, Lucie; Kuča, Kamil; Perez, Daniel I.; Perez, Concepcion; Martinez, Ana; Fišar, Zdeněk; Musílek, Kamil: 1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders. In: Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, roč. 33, č. 1. s. 665-670. IF 4.293.
Honegr, Jan; Maliňák, Dávid; Doležal, Rafael; Soukup, Ondřej; Benková, Markéta; Hroch, Lukáš; Benek, Ondřej; Janočková, Jana; Kuča, Kamil; Prymula, Roman: Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro. In: European Journal of Medicinal Chemistry, 2018, roč. 146, č. February. s. 38-46. IF 4.519.
Honegr, Jan; Doležal, Rafael; Maliňák, Dávid; Benková, Markéta; Soukup, Ondřej; de Almeida, Joyce S.F.D.; Franca, Tanos C. C.; Kuča, Kamil; Prymula, Roman: Rational Design of a New Class of Toll-Like Receptor 4 (TLR4) Tryptamine Related Agonists by Means of the Structure- and Ligand-Based Virtual Screening for Vaccine Adjuvant Discovery. In: Molecules, 2018, roč. 23, č. 1. s. nestránkováno. IF 2.861.
Klímová, Blanka; Marešová, Petra; Novotný, Michal; Kuča, Kamil: A Global View on Narcolepsy - A Review Study. In: Mini-Reviews in Medicinal Chemistry, 2018, roč. 18, č. 5. s. 458-464. IF 2.661.
Klímová, Blanka; Novotný, Michal; Kuča, Kamil: Semantic Dementia: A Mini-Review. In: Mini-Reviews in Medicinal Chemistry, 2018, roč. 18, č. 1. s. 3-8. IF 2.661.
Korábečný, Jan; Nepovimová, Eugenie; Cikánková, Tereza; Špilovská, Katarína; Vašková, Lucie; Mezeiová, Eva; Kuča, Kamil; Hroudová, Jana: Newly developed drugs for Alzheimer's disease in relation to energy metabolism, cholinergic and monoaminergic neurotransmission. In: Neuroscience, 2018, roč. 370, č. February. s. 191-206. IF 3.277.
Kuča, Kamil; Musílek, Kamil; Jun, Daniel; Žďárová Karasová, Jana; Nepovimová, Eugenie; Soukup, Ondřej; Hrabinová, Martina; Mikler, John; Franca, Tanos C. C.; Da Cunha, Elaine F. F.; De Castro, Alexandre A.; Vališ, Martin; Ramalho, Teodorico: A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase. In: BMC pharmacology & toxicology, 2018, roč. 19, č. February. s. nestránkováno. IF 2.288.
Kuča, Kamil; Žďárová Karasová, Jana; Soukup, Ondřej; Kassa, Jiří; Novotná, Eva; Šepsová, Vendula; Horová, Anna; Pejchal, Jaroslav; Hrabinová, Martina; Vodáková, Eva; Jun, Daniel; Nepovimová, Eugenie; Vališ, Martin; Musílek, Kamil: Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings. In: Drug Design, Development and Therapy, 2018, roč. neuveden, č. 12. s. 505-512. IF 2.822.
Marek, Jan; Maliňák, Dávid; Doležal, Rafael; Soukup, Ondřej; Benková, Markéta; Nachtigal, Petr; Vavral, Petr; Kuča, Kamil: Novel Series of Quaternary Ammonium Surfactants Based on 2,3-Dihydro-[1,4]dioxino[2.3-b]pyridin-7-ol Ring: Synthesis, Analysis and Antimicrobial Evaluation. In: Letters in Organic Chemistry, 2018, roč. 15, č. 1. s. 3-9. IF 0.730.
Mezeiová, Eva; Špilovská, Katarína; Nepovimová, Eugenie; Górecki, Lukáš; Soukup, Ondřej; Doležal, Rafael; Maliňák, Dávid; Janočková, Jana; Jun, Daniel; Kuča, Kamil; Korábečný, Jan: Profiling donepezil template into multipotent hybrids with antioxidant properties. In: Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, roč. 33, č. 1. s. 583-606. IF 4.293.
Pavlíková, Růžena; Misík, Jan; Cabal, Jiří; Marek, Jan; Kuča, Kamil: In vitro skin decontamination of paraoxon - wet-type cleansing effect of selected detergents. In: Cutaneous and Ocular Toxicology, 2018, roč. 37, č. 1. s. 77-83. IF 1.213.
Soukup, Ondřej; Korábečný, Jan; Maliňák, Dávid; Nepovimová, Eugenie; Pham, Ngoc L.; Musílek, Kamil; Hrabinova, Martina; Hepnarova, Vendula; Doležal, Rafael; Pávek, Petr; Jost, Petr; Kobrlová, Tereza; Janočková, Jana; Górecki, Lukáš; Psotka, Miroslav; Nguyen, Thuy Duong; Box, Karl; Outhwaite, Breeze; Čečková, Martina; Šorf, Aleš; Jun, Daniel; Kuča, Kamil: In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?. In: Medicinal Chemistry, 2018, roč. 14, č. 3. s. 281-292. IF 2.331.
Žárská, Monika; Sramek, Michal; Novotný, Filip; Havel, Filip; Babelova, Andrea; Mrazkova, Hanka; Benada, Oldřich; Reinis, Milan; Stepanek, Ivan; Musílek, Kamil; Bartek, Jiří; Ursinyova, Monika; Novák, Ondřej; Dzijak, Rastislav; Kuča, Kamil; Proška, Jan; Hodný, Zdeněk: Biological safety and tissue distribution of (16-mercaptohexadecyl) trimethylammonium bromide-modified cationic gold nanorods. In: Biomaterials, 2018, roč. 154, č. February. s. 275-290. IF 8.402.
Žďárová Karasová, Jana; Mžik, Martin; Hroch, Miloš; Korábečný, Jan; Nepovimová, Eugenie; Voříšek, Viktor; Palička, Vladimír; Kuča, Kamil: The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-Methoxytacrine-Donepezil-Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics and In Vivo Formation of the Major Metabolites in Rats. In: Basic & Clinical Pharmacology & Toxicology, 2018, roč. 122, č. 4. s. 373-382. IF 3.176.
Babková, Kateřina; Korábečný, Jan; Soukup, Ondřej; Nepovimová, Eugenie; Jun, Daniel; Kuča, Kamil: Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors. In: Future Medicinal Chemistry, 2017, roč. 9, č. 10. s. 1015-1038. IF 3.556.
Benek, Ondřej; Hroch, Lukáš; Aitken, Laura; Doležal, Rafael; Hughes, Rebecca; Guest, Patrick; Benková, Markéta; Soukup, Ondřej; Musil, Karel; Kuča, Kamil; Smith, Terry K.; Gunn-Moore, Frank; Musílek, Kamil: 6-Benzothiazolyl ureas, thioureas and guanidines are potent inhibitors of ABAD/17 beta-HSD10 and potential drugs for Alzheimer's disease treatment: Design, synthesis and in vitro evaluation. In: Medicinal Chemistry, 2017, roč. 13, č. 4. s. 345-358. IF 2.331.
Blažek, Pavel; Kuča, Kamil; Jun, Daniel; Krejcar, Ondřej: Development of information and management system for laboratory based on open source licensed software with security logs extension. In: Journal of Intelligent and Fuzzy Systems, 2017, roč. 32, č. 2. s. 1497-1508. IF 1.261.
Gazova, Zuzana; Soukup, Ondřej; Šepsová, Vendula; Siposova, Katarina; Drtinová, Lucie; Jošt, Petr; Špilovská, Katarína; Korábečný, Jan; Nepovimová, Eugenie; Fedunová, Diana; Horák, Martin; Kaniaková, Martina; Wang, Ze-Jun; Hamouda, Ayman K.; Kuča, Kamil: Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment. In: Biochimica et Biophysica Acta - Molecular Basis of Disease, 2017, roč. 1863, č. 2. s. 607-619. IF 5.476.
Górecki, Lukáš; Korábečný, Jan; Musílek, Kamil; Nepovimová, Eugenie; Maliňák, Dávid; Kučera, Tomáš; Doležal, Rafael; Jun, Daniel; Soukup, Ondřej; Kuča, Kamil: Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016). In: Expert Opinion on Therapeutic Patents, 2017, roč. 27, č. 9. s. 971-985. IF 3.041.
Hamuláková, Slávka; Janovec, Ladislav; Soukup, Ondřej; Jun, Daniel; Kuča, Kamil: Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids. In: International Journal of Biological Macromolecules, 2017, roč. 104, č. Part A. s. 333-338. IF 3.671.
Hamuláková, Slávka; Kožurková, Mária; Kuča, Kamil: Coumarin derivatives in pharmacotherapy of Alzheimer's disease. In: Current Organic Chemistry, 2017, roč. 21, č. 7. s. 602-612. IF 1.924.
Holas, Ondřej; Korábečný, Jan; Gažová, Zuzana; Šipošová, Katarína; Musílek, Kamil; Opletalová, Veronika; Górecki, Lukáš; Nepovimová, Eugenie; Špilovská, Katarína; Mezeiová, Eva; Kuča, Kamil: Alzheimer's disease drugs - In Vitro comparison of cholinesterase inhibition and beta-amyloid modulation. In: Letters in Drug Design & Discovery, 2017, roč. 14, č. 6. s. 743-750. IF 1.170.
Horak, Martin; Holubova, Kristina; Nepovimová, Eugenie; Krusek, Jan; Kaniakova, Martina; Korábečný, Jan; Vyklicky, Ladislav; Kuča, Kamil; Stuchlik, Ales; Ricny, Jan; Vales, Karel; Soukup, Ondřej: The pharmacology of tacrine at N-methyl-D-aspartate receptors. In: Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2017, roč. 75, č. April. s. 54-62. IF 4.187.
Hrabcová, Veronika; Korábečný, Jan; Mányová, Brigita; Matoušková, Lenka; Kučera, Tomáš; Doležal, Rafael; Musílek, Kamil; Górecki, Lukáš; Nepovimová, Eugenie; Kuča, Kamil; Jun, Daniel: Bis-isoquinolinium and bis-pyridinium acetylcholinesterase inhibitors: in vitro screening of probes for novel selective insecticides. In: RSC Advances, 2017, roč. 7, č. 62. s. 39279-39291. IF 3.108.
Hroch, Lukáš; Guest, Patrick; Benek, Ondřej; Soukup, Ondřej; Janočková, Jana; Doležal, Rafael; Kuča, Kamil; Aitken, Laura; Smith, Terry K.; Gunn-Moore, Frank; Zala, Dominykas; Ramsay, Rona R.; Musílek, Kamil: Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment. In: Bioorganic & Medicinal Chemistry, 2017, roč. 25, č. 3. s. 1143-1152. IF 2.930.
Chen, Liangkai; Yu, Miao; Wu, Qinghua; Peng, Zhao; Wang, Di; Kuča, Kamil; Yao, Ping; Yan, Hong; Nuessler, Andreas K.; Liu, Liegang; Yang, Wei: Gender and geographical variability in the exposure pattern and metabolism of deoxynivalenol in humans: a review. In: Journal of Applied Toxicology, 2017, roč. 37, č. 1. s. 60-70. IF 3.159.
Jacevic, Vesna; Djordjevic, Aleksandar; Srdjenovic, Branislava; Milic-Tores, Vukosava; Segrt, Zoran; Dragojevic-Simic, Viktorija; Kuča, Kamil: Fullerenol nanoparticles prevents doxorubicin-induced acute hepatotoxicity in rats. In: Experimental and Molecular Pathology, 2017, roč. 102, č. 2. s. 360-369. IF 2.423.
Jeřábek, Jakub; Uliassi, Elisa; Guidotti, Laura; Korábečný, Jan; Soukup, Ondřej; Šepsová, Vendula; Hrabinová, Martina; Kuča, Kamil; Bartolini, Manuela; Pena-Altamira, Luis Emiliano; Petralla, Sabrina; Monti, Barbara; Roberti, Marinella; Bolognesi, Maria Laura: Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease. In: European Journal of Medicinal Chemistry, 2017, roč. 127, č. February. s. 250-262. IF 4.519.
Kapitanov, Illia V.; Mirgorodskaya, Alla B.; Valeeva, Farida G.; Gathergood, Nicholas; Kuča, Kamil; Zakharova, Lucia Ya; Karpichev, Yevgen: Physicochemical properties and esterolytic reactivity of oxime functionalized surfactants in pH-responsive mixed micellar system. In: Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2017, roč. 524, č. July. s. 143-159. IF 2.714.
Klímová, Blanka; Kuča, Kamil; Novotný, Michal; Marešová, Petra: Cystic Fibrosis Revisited - a Review Study. In: Medicinal Chemistry, 2017, roč. 13, č. 2. s. 102-109. IF 2.331.
Klímová, Blanka; Vališ, Martin; Kuča, Kamil: Dancing as an Intervention Tool for People with Dementia: A Mini-Review Dancing and Dementia. In: Current Alzheimer Research, 2017, roč. 14, č. 12. s. 1264-1269. IF 2.952.
Klímová, Blanka; Vališ, Martin; Kuča, Kamil: Potential of mobile technologies and applications in the detection of mild cognitive impairment among older generation groups. In: Social Work in Health Care, 2017, roč. 56, č. 7. s. 588-599. IF 0.945.
Klímová, Blanka; Vališ, Martin; Kuča, Kamil: Cognitive decline in normal aging and its prevention: a review on non-pharmacological lifestyle strategies. In: Clinical interventions in aging [online], 2017, roč. 12, č. neuvedeno. s. 903-910. IF 2.581.
Klímová, Blanka; Storek, Michal; Vališ, Martin; Kuča, Kamil: Global View on Rare Diseases: A Mini Review. In: Current Medicinal Chemistry, 2017, roč. 24, č. 29. s. 3153-3158. IF 3.249.
Klímová, Blanka; Kuča, Kamil: Alzheimer's Disease and Chinese Medicine as a Useful Alternative Intervention Tool: A Mini-Review. In: Current Alzheimer Research, 2017, roč. 14, č. 6. s. 680-685. IF 2.952.
Klímová, Blanka; Vališ, Martin; Kuča, Kamil: Bilingualism as a strategy to delay the onset of Alzheimer's disease. In: Clinical interventions in aging [online], 2017, roč. 12, č. neuvedeno. s. 1731-1737. IF 2.581.
Kocourková, Aneta; Honegr, Jan; Kuča, Kamil; Dáňová, Jana: Vaccine ingredients: Components that influence vaccine efficacy. In: Mini-Reviews in Medicinal Chemistry, 2017, roč. 17, č. 5. s. 451-466. IF 2.661.
Kristofikova, Zdenka; Ricny, Jan; Soukup, Ondřej; Korábečný, Jan; Nepovimová, Eugenie; Kuča, Kamil; Ripova, Daniela: Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1. In: Dementia and Geriatric Cognitive Disorders, 2017, roč. 43, č. 1-2. s. 45-58. IF 3.511.
Kuča, Kamil; Korábečný, Jan; Doležal, Rafael; Nepovimová, Eugenie; Soukup, Ondřej; Górecki, Lukáš; Musílek, Kamil: Tetroxime: reactivation potency - in vitro and in silico study. In: RSC Advances, 2017, roč. 7, č. 12. s. 7041-7045. IF 3.108.
Mezeiová, Eva; Korábečný, Jan; Šepsová, Vendula; Hrabinová, Martina; Jošt, Petr; Múčková, Ľubica; Kučera, Tomáš; Doležal, Rafael; Misík, Jan; Špilovská, Katarína; Pham, Ngoc Lam; Pokrievková, Lucia; Roh, Jaroslav; Jun, Daniel; Soukup, Ondřej; Kaping, Daniel; Kuča, Kamil: Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy. In: Molecules, 2017, roč. 22, č. 8. s. nestránkováno. IF 2.861.
Nurulain, S.M.; Ojha, S.; Dhanasekaran, S.; Kuča, Kamil; Nalin, N.; Sharma, C.; Adem, A.; Kalasz, H.: HPLC determination of K027 in the body of pregnant mice. In: Acta Chromatographica, 2017, roč. 29, č. 1. s. 85-93. IF 0.755.
Sales, Thais A.; Marcussi, Silvana; da Cunha, Elaine F. F.; Kuča, Kamil; Ramalho, Teodorico C.: Can Inhibitors of Snake Venom Phospholipases A(2) Lead to New Insights into Anti-Inflammatory Therapy in Humans? A Theoretical Study. In: Toxins, 2017, roč. 9, č. 11. s. nestránkováno. IF 3.030.
Soukup, Ondřej; Winder, Michael; Killi, Uday Kumar; Wsól, Vladimír; Jun, Daniel; Kuča, Kamil; Tobin, Gunnar: Acetylcholinesterase inhibitors and drugs acting on muscarinic receptors-potential crosstalk of cholinergic mechanisms during pharmacological treatment. In: Current Neuropharmacology, 2017, roč. 15, č. 4. s. 637-653. IF 3.365.
Soukup, Ondřej; Stralkova, Radomíra; Mistova, Tereza; Popov, Marek; Hejtmankova, Alena; Lachman, Jaromír; Klímová, Blanka; Kuča, Kamil: Polyphenolic compound from Vitis vinifera L. have potential for the Alzheimer disease treatment. In: Letters in Drug Design & Discovery, 2017, roč. 14, č. 7. s. 853-859. IF 1.170.
Špilovská, Katarína; Korábečný, Jan; Nepovimová, Eugenie; Doležal, Rafael; Mezeiová, Eva; Soukup, Ondřej; Kuča, Kamil: Multitarget tacrine hybrids with neuroprotective properties to confront Alzheimer's disease. In: Current Topics in Medicinal Chemistry, 2017, roč. 17, č. 9. s. 1006-1026. IF 2.561.
Špilovská, Katarína; Korábečný, Jan; Šepsová, Vendula; Jun, Daniel; Hrabinová, Martina; Jošt, Petr; Múčková, Lubica; Soukup, Ondřej; Janočková, Jana; Kučera, Tomáš; Doležal, Rafael; Mezeiová, Eva; Kaping, Daniel; Kuča, Kamil: Novel Tacrine-Scutellarin hybrids as multipotent Anti-Alzheimer's agents: Design, synthesis and biological evaluation. In: Molecules, 2017, roč. 22, č. 6. s. nestránkováno. IF 2.861.
Vališ, Martin; Masopust, Jiří; Vyšata, Oldřich; Hort, Jakub; Doležal, Rafael; Tomek, Jiří; Misík, Jan; Kuča, Kamil; Žďárová Karasová, Jana: Concentration of Donepezil in the Cerebrospinal Fluid of AD Patients: Evaluation of Dosage Sufficiency in Standard Treatment Strategy. In: Neurotoxicity Research, 2017, roč. 31, č. 1. s. 162-168. IF 2.942.
Wu, Qinghua; Kuča, Kamil; Humpfl, Hans-Ulrich; Klímová, Blanka; Cramer, Benedikt: Fate of deoxynivalenol and deoxynivalenol-3-glucoside during cereal-based thermal food processing: a review study. In: Mycotoxin Research, 2017, roč. 33, č. 1. s. 79-91. IF 2.706.
Zonča, Pavel; Malý, Tomáš; Ihnát, Peter; Peteja, Matus; Kraft, Otakar; Kuča, Kamil: J-pouch versus Roux-en-Y reconstruction after gastrectomy: functional assessment and quality of life (randomized trial). In: OncoTargets and Therapy, 2017, roč. 10, č. January. s. 13-19. IF 1.653.
Žďárová Karasová, Jana; Květina, Jaroslav; Tachecí, Ilja; Radochová, Věra; Musílek, Kamil; Kuča, Kamil; Bureš, Jan: Pharmacokinetic profile of promising acetylcholinesterase reactivators K027 and K203 in experimental pigs. In: Toxicology Letters, 2017, roč. 273, č. May. s. 20-25. IF 3.858.
Žďárová Karasová, Jana; Maderycová, Zuzana; Tůmová, Martina; Jun, Daniel; Řeháček, Vít; Kuča, Kamil; Misík, Jan: Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis. In: Toxicology Letters, 2017, roč. 277, č. August. s. 24-31. IF 3.858.
Andrš, Martin; Muthná, Darina; Řezáčová, Martina; Seifrtová, Martina; Šiman, Pavel; Korábečný, Jan; Benek, Ondřej; Doležal, Rafael; Soukup, Ondřej; Jun, Daniel; Kuča, Kamil: Novel caffeine derivatives with antiproliferative activity. In: RSC Advances, 2016, roč. 6, č. 39. s. 32534-32539. IF 3.108.
Andrš, Martin; Korábečný, Jan; Nepovimová, Eugenie; Jun, Daniel; Hodný, Zdeněk; Kuča, Kamil: Small Molecules Targeting Ataxia Telangiectasia and Rad3-Related (ATR) Kinase: An Emerging way to Enhance Existing Cancer Therapy. In: Current Cancer Drug Targets, 2016, roč. 16, č. 3. s. 200-208. IF 2.992.
Antonijevic, Evica; Musílek, Kamil; Kuča, Kamil; Djukic-Cosic, Danijela; Vucinic, Slavica; Antonijevic, Biljana: Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor. In: NeuroToxicology, 2016, roč. 55, č. July. s. 33-39. IF 3.100.
Benek, Ondřej; Soukup, Ondřej; Pasdiorová, Markéta; Hroch, Lukáš; Šepsová, Vendula; Jošt, Petr; Hrabinová, Martina; Jun, Daniel; Kuča, Kamil; Zala, Dominykas; Ramsay, Rona R.; Marco-Contelles, José; Musílek, Kamil: Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease. In: ChemMedChem, 2016, roč. 11, č. 12. s. 1264-1269. IF 3.225.
Bureš, Vladimír; Čech, Pavel; Mikulecká, Jaroslava; Ponce, Daniela; Kuča, Kamil: The effect of cognitive training on the subjective perception of well-being in older adults. In: PeerJ, 2016, roč. 4, č. December. s. nestránkováno. IF 2.177.
Buzga, Marek; Marešová, Petra; Seidlerová, Adéla; Zonča, Pavel; Holéczy, Pavol; Kuča, Kamil: The influence of methods of bariatric surgery for treatment of type 2 diabetes mellitus. In: Therapeutics and Clinical Risk Management, 2016, roč. 12, č. neuvedeno. s. 599-605. IF 2.200.
Doležal, Rafael; Soukup, Ondřej; Maliňák, Dávid; Savedra M.L., Ranylson; Marek, Jan; Doležalová, Marie; Pasdiorová, Markéta; Salajková, Šárka; Korábečný, Jan; Honegr, Jan; Ramalho C., Teodorico; Kuča, Kamil: Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies. In: European Journal of Medicinal Chemistry, 2016, roč. 121, č. October. s. 699-711. IF 4.519.
Górecki, Lukáš; Korábečný, Jan; Musílek, Kamil; Maliňák, Dávid; Nepovimová, Eugenie; Doležal, Rafael; Jun, Daniel; Soukup, Ondřej; Kuča, Kamil: SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides. In: Archives of Toxicology, 2016, roč. 90, č. 12. s. 2831-2859. IF 5.901.
Hamulakova, Slavka; Poprac, Patrik; Jomova, Klaudia; Brezova, Vlasta; Lauro, Peter; Drostinova, Lenka; Jun, Daniel; Šepsová, Vendula; Hrabinová, Martina; Soukup, Ondřej; Kristian, Pavol; Gazova, Zuzana; Bednarikova, Zuzana; Kuča, Kamil; Valko, Marian: Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules. In: Journal of Inorganic Biochemistry, 2016, roč. 161, č. August. s. 52-62. IF 3.348.
Hroch, Lukáš; Benek, Ondřej; Guest, Patrick; Aitken, Laura; Soukup, Ondřej; Janočková, Jana; Musil, Karel; Dohnal, Vlastimil; Doležal, Rafael; Kuča, Kamil; Smith, Terry K.; Gunn-Moore, Frank; Musílek, Kamil: Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17 beta-HSD10 modulators for Alzheimer's disease treatment. In: Bioorganic and Medicinal Chemistry Letters, 2016, roč. 26, č. 15. s. 3675-3678. IF 2.454.
Jacevic, Vesna; Jovic, Danica; Kuča, Kamil; Dragojevic-Simic, Viktorija; Dobric, Silva; Trajkovic, Sanja; Borisev, Ivana; Segrt, Zoran; Milovanovic, Zoran; Bokonjic, Dubravko; Djordjevic, Aleksandar: Effects of fullerenol nanoparticles and amifostine on radiation-induced tissue damages: Histopathological analysis. In: Journal of Applied Biomedicine, 2016, roč. 14, č. 4. s. 285-297. IF 1.433.
Janočková, Jana; Žilecká, Eva; Kašpárková, Jana; Brabec, Viktor; Soukup, Ondřej; Kuča, Kamil; Kožurková, Mária: Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity. In: Molecular BioSystems, 2016, roč. 12, č. 9. s. 2910-2920. IF 2.781.
Klímová, Blanka; Kuča, Kamil: Speech and language impairments in dementia. In: Journal of Applied Biomedicine, 2016, roč. 14, č. 2. s. 97-103. IF 1.433.
Klímová, Blanka; Marešová, Petra; Kuča, Kamil: Assistive technologies for managing language disorders in dementia. In: Neuropsychiatric Disease and Treatment, 2016, roč. 12, č. neuvedeno. s. 533-540. IF 2.198.
Klímová, Blanka; Simonová, Ivana; Poulová, Petra; Truhlářová, Zuzana; Kuča, Kamil: Older people and their attitude to the use of information and communication technologies - A review study with special focus on the Czech Republic (Older people and their attitude to ICT). In: Educational Gerontology, 2016, roč. 42, č. 5. s. 361-369. IF 0.674.
Klímová, Blanka; Marešová, Petra; Kuča, Kamil: Non-Pharmacological approaches to the prevention and treatment of Alzheimer's disease with respect to the rising treatment costs. In: Current Alzheimer Research, 2016, roč. 13, č. 11. s. 1249-1258. IF 2.952.
Klímová, Blanka; Kuča, Kamil: Multi-Nutrient dietary intervention approach to the management of Alzheimer's disease - A Mini-review. In: Current Alzheimer Research, 2016, roč. 13, č. 12. s. 1312-1318. IF 2.952.
Kmochová, Adéla; Tichý, Aleš; Zárybnická, Lenka; Šinkorová, Zuzana; Vávrová, Jiřina; Řeháček, Vít; Ďurišová, Kamila; Kubelková, Klára; Pejchal, Jaroslav; Kuča, Kamil: Modulation of ionizing radiation-induced effects by NU7441, KU55933 and VE821 in peripheral blood lymphocytes. In: Journal of Applied Biomedicine, 2016, roč. 14, č. 1. s. 19-24. IF 1.433.
Kuča, Kamil; Soukup, Ondřej; Marešová, Petra; Korábečný, Jan; Nepovimová, Eugenie; Klímová, Blanka; Honegr, Jan; Ramalho, Teodorico C.; Franca, Tanoc C.C.: Current Approaches Against Alzheimer's Disease in Clinical Trials. In: Journal of the Brazilian Chemical Society, 2016, roč. 27, č. 4. s. 641-649. IF 1.198.
Kuča, Kamil; Musílek, Kamil; Jun, Daniel: TRISOXIME - a bulky trisquaternary reactivator of acetylcholinesterase. In: Letters in Drug Design & Discovery, 2016, roč. 13, č. 5. s. 372-375. IF 1.170.
Marešová, Petra; Klímová, Blanka; Novotný, Michal; Kuča, Kamil: Alzheimer's and Parkinson's Diseases: Expected Economic Impact on Europe-A Call for a Uniform European Strategy. In: Journal of Alzheimer's Disease, 2016, roč. 54, č. 3. s. 1123-1133. IF 3.731.
Marešová, Petra; Klímová, Blanka; Kuča, Kamil: Financial and legislative aspects of drug development of orphan diseases on the European market - a systematic review. In: Applied Economics, 2016, roč. 48, č. 27. s. 2562-2570. IF 0.648.
Marešová, Petra; Mohelská, Hana; Kuča, Kamil: Social and family load of Alzheimer's disease. In: Applied Economics, 2016, roč. 48, č. 21. s. 1936-1948. IF 0.648.
Marešová, Petra; Novotný, Michal; Klímová, Blanka; Kuča, Kamil: Treatment cost of narcolepsy with cataplexy in Central Europe. In: Therapeutics and Clinical Risk Management, 2016, roč. 12, č. 12. s. 1709-1715. IF 2.200.
Marešová, Petra; Klímová, Blanka; Vališ, Martin; Kuča, Kamil; Mohelská, Hana: Treatment costs of Parkinson's disease in Central Europe. In: E+M. Ekonomie a Management, 2016, roč. 19, č. 3. s. 31-39. IF 1.163.
Musil, Karel; Floriánová, Veronika; Bucek, Pavel; Dohnal, Vlastimil; Kuča, Kamil; Musílek, Kamil: Development and validation of a FIA/UV-vis method for pK(a) determination of oxime based acetylcholinesterase reactivators. In: Journal of Pharmaceutical and Biomedical Analysis, 2016, roč. 117, č. January. s. 240-246. IF 3.255.
Musílek, Kamil; Hambálek, Jan; Holas, Ondřej; Dohnal, Vlastimil; Kuča, Kamil: Monooxime bispyridinium reactivators bearing xylene linker synthesis and in vitro evaluation on model of organophosphate-inhibited acetylcholinesterase. In: Medicinal Chemistry, 2016, roč. 12, č. 4. s. 362-370. IF 2.331.
Mžik, Martin; Korábečný, Jan; Nepovimová, Eugenie; Voříšek, Viktor; Palička, Vladimír; Kuča, Kamil; Žďárová Karasová, Jana: An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study. In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2016, roč. 1020, č. May. s. 85-89. IF 2.603.
Nepovimová, Eugenie; Korábečný, Jan; Doležal, Rafael; Nguyen, T. D.; Jun, Daniel; Soukup, Ondřej; Pasdiorová, Markéta; Jošt, Petr; Muckova, L.; Maliňák, Dávid; Górecki, Lukáš; Musílek, Kamil; Kuča, Kamil: A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication. In: Toxicology Research, 2016, roč. 5, č. 4. s. 1012-1016. IF 1.969.
Patočka, Jiří; Wu, Qinghua; Franca, Tanos C. C.; Ramalho, Teodorico C.; Pita, Rene; Kuča, Kamil: Clinical aspects of the poisoning by the pesticide endosulfan. In: Quimica Nova, 2016, roč. 39, č. 8. s. 987-994. IF 0.567.
Pejchal, Jaroslav; Šinkorová, Zuzana; Tichý, Aleš; Průchová, Šárka; Kmochová, Adéla; Ďurišová, Kamila; Čecháková, Lucie; Lierová, Anna; Ondrej, Martin; Němcová, Markéta; Kubelková, Klára; Fátorová, Ilona; Bureš, Jan; Tachecí, Ilja; Kuča, Kamil; Vávrová, Jiřina: Epidermal growth factor attenuates delayed Ionizing radiation- induced tissue damage in bone marrow transplanted mice. In: Radiation Research, 2016, roč. 186, č. 3. s. 264-274. IF 2.539.
Ramalho, Teodorico C.; de Castro, Alexandre A.; Silva, Daniela R.; Silva, Maria Cristina; Franca, Tanos C. C.; Bennion, Brian J.; Kuča, Kamil: Computational enzymology and organophosphorus degrading enzymes: promising approaches toward remediation technologies of warfare agents and pesticides. In: Current Medicinal Chemistry, 2016, roč. 23, č. 10. s. 1041-1061. IF 3.249.
Sahu, Arvind Kumar; Sharma, Rahul; Gupta, Bhanushree; Musílek, Kamil; Kuča, Kamil; Acharya, Jyotiranjan; Ghosh, Kallol K.: Oxime-mediated in vitro reactivation kinetic analysis of organophosphates-inhibited human and electric eel acetylcholinesterase. In: Toxicology Mechanisms and Methods, 2016, roč. 26, č. 5. s. 319-326. IF 1.595.
Sharma, Rahul; Gupta, Bhanushree; Yadav, Toshikee; Sinha, Srishti; Sahu, Arvind Kumar; Karpichev, Yevgen; Gathergood, Nicholas; Marek, Jan; Kuča, Kamil; Ghosh, Kallol K.: Degradation of organophosphate pesticides using pyridinium based functional surfactants. In: ACS Sustainable Chemistry & Engineering, 2016, roč. 4, č. 12. s. 6962-6973. IF 5.951.
Soběslav, Vladimír; Marešová, Petra; Krejcar, Ondřej; Franca, Tanos CC; Kuča, Kamil: Use of cloud computing in biomedicine. In: Journal of Biomolecular Structure and Dynamics, 2016, roč. 34, č. 12. s. 2688-2697. IF 3.123.
Soukup, Ondřej; Doležal, Rafael; Maliňák, Dávid; Marek, Jan; Salajková, Šárka; Pasdiorová, Markéta; Honegr, Jan; Korábečný, Jan; Nachtigal, Petr; Nachon, Florian; Jun, Daniel; Kuča, Kamil: Synthesis, antimicrobial evaluation and molecular modeling of 5-hydroxyisoquinolinium salt series; the effect of the hydroxyl moiety. In: Bioorganic and Medicinal Chemistry, 2016, roč. 24, č. 4. s. 841-848. IF 2.930.
Špičáková, Alena; Anzenbacher, Pavel; Lišková, Barbora; Kuča, Kamil; Fusek, Josef; Anzenbacherová, Eva: Evaluation of possible inhibition of human liver drug metabolizing cytochromes P450 by two new acetylcholinesterase oxime-type reactivators. In: Food and Chemical Toxicology, 2016, roč. 88, č. February. s. 100-104. IF 3.778.
Špilovská, Katarína; Zemek, Filip; Korábečný, Jan; Nepovimová, Eugenie; Soukup, Ondřej; Windisch, Manfred; Kuča, Kamil: Adamantane - A lead structure for drugs in clinical practice. In: Current Medicinal Chemistry, 2016, roč. 23, č. 29. s. 3245-3266. IF 3.249.
Valko, Marian; Jomova, Klaudia; Rhodes, Christoper J.; Kuča, Kamil; Musílek, Kamil: Redox- and non-redox metal induced formation of free radicals and their role in human disease. In: Archives of Toxicology, 2016, roč. 90, č. 1. s. 1-37. IF 5.901.
Wang, Liye; Huang, Lingli; Pan, Yuanhu; Kuča, Kamil; Klímová, Blanka; Wu, Qinghua; Xie, Shuyu; Ahmad, Ijaz; Chen, Dongmei; Tao, Yanfei; Wan, Dan; Liu, Zhenli; Yuan, Zonghui: Metabolism and disposition of aditoprim in swine, broilers, carp and rats. In: Scientific Reports, 2016, roč. 6, č. February. s. nestránkováno. IF 4.259.
Winter, Michael; Wille, Timo; Musílek, Kamil; Kuča, Kamil; Thiermann, Horst; Worek, Franz: Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase. In: Toxicology Letters, 2016, roč. 244, č. February. s. 136-142. IF 3.858.
Wu, Qinghua; Liu, Lian; Miron, Anca; Klímová, Blanka; Wan, Dan; Kuča, Kamil: The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview. In: Archives of Toxicology, 2016, roč. 90, č. 8. s. 1817-1840. IF 5.901.
Žárská, Monika; Novotný, Filip; Havel, Filip; Šrámek, Michal; Bábelová, Andrea; Benada, Oldřich; Novotný, Michal; Saran, Hilal; Kuča, Kamil; Musílek, Kamil; Hvězdová, Zuzana; Dzijak, Rastislav; Vančurová, Markéta; Krejčíková, Kateřina; Gabajová, Blanka; Hanzlíková, Hana; Kyjacová, Lenka; Bártek, Jiří; Proska, Jan; Hodný, Zdeněk: Two-step mechanism of cellular uptake of cationic gold nanoparticles modified by (16-Mercaptohexadecyl)trimethylammonium bromide. In: Bioconjugate Chemistry, 2016, roč. 27, č. 10. s. 2558-2574. IF 4.818.
Žďárová Karasová, Jana; Hroch, Miloš; Musílek, Kamil; Kuča, Kamil: Small Quaternary Inhibitors K298 and K524: Cholinesterases Inhibition, Absorption, Brain Distribution, and Toxicity. In: Neurotoxicity Research, 2016, roč. 29, č. 2. s. 267-274. IF 2.942.
Andrš, Martin; Korábečný, Jan; Jun, Daniel; Hodný, Zdeněk; Bártek, Jiří; Kuča, Kamil: Phosphatidylinositol 3-Kinase (PI3K) and Phosphatidylinositol 3-Kinase-Related Kinase (PIKK) Inhibitors: Importance of the Morpholine Ring. In: Journal of Medicinal Chemistry, 2015, roč. 58, č. 1. s. 41-71. IF 6.259.
Benek, Ondřej; Musílek, Kamil; Horová, Anna; Dohnal, Vlastimil; Doležal, Rafael; Kuča, Kamil: Preparation, In Vitro Screening and Molecular Modelling of Monoquaternary Compounds Related to the Selective Acetylcholinesterase Inhibitor BW284c51. In: Medicinal Chemistry, 2015, roč. 11, č. 1. s. 21-29. IF 2.331.
Benek, Ondřej; Aitken, Laura; Hroch, Lukáš; Kuča, Kamil; Gunn-Moore, Frank; Musílek, Kamil: A Direct Interaction Between Mitochondrial Proteins and Amyloid-beta Peptide and its Significance for the Progression and Treatment of Alzheimer's Disease. In: Current Medicinal Chemistry, 2015, roč. 22, č. 9. s. 1056-1085. IF 3.249.
Bureš, Jan; Květina, Jaroslav; Tachecí, Ilja; Pavlík, Michal; Kuneš, Martin; Rejchrt, Stanislav; Kuča, Kamil; Kopáčová, Marcela: The effect of different doses of atropine on gastric myoelectrical activity in fasting experimental pigs. In: Journal of Applied Biomedicine, 2015, roč. 13, č. 4. s. 273-277. IF 1.433.
Bureš, Jan; Jun, Daniel; Hrabinová, Martina; Tachecí, Ilja; Květina, Jaroslav; Pavlík, Michal; Rejchrt, Stanislav; Douda, Tomáš; Kuneš, Martin; Kuča, Kamil; Kopáčová, Marcela: Impact of tacrine and 7-methoxytacrine on gastric myoelectrical activity assessed using electrogastrography in experimental pigs. In: Neuroendocrinology Letters, 2015, roč. 36, č. Suppl. 1. s. 150-155. IF 0.918.
Doležal, Rafael; Korábečný, Jan; Maliňák, Dávid; Honegr, Jan; Musílek, Kamil; Kuča, Kamil: Ligand-based 3D QSAR analysis of reactivation potency of mono- and bis-pyridinium aldoximes toward VX-inhibited rat acetylcholinesterase. In: Journal of Molecular Graphics and Modelling, 2015, roč. 56, č. 1. s. 113-129. IF 1.754.
Giacoppo, Juliana O. S.; Franca, Tanos C. C.; Kuča, Kamil; da Cunha, Elaine F. F.; Abagyan, Ruben; Mancini, Daiana T.; Ramalho, Teodorico C.: Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents. In: Journal of Biomolecular Structure and Dynamics, 2015, roč. 33, č. 9. s. 2048-2058. IF 3.123.
Honegr, Jan; Soukup, Ondřej; Doležal, Rafael; Maliňák, Dávid; Penhaker, Marek; Prymula, Roman; Kuča, Kamil: Structural Properties of Potential Synthetic Vaccine Adjuvants - TLR Agonists. In: Current Medicinal Chemistry, 2015, roč. 22, č. 29. s. 3306-3325. IF 3.249.
Horn, Gabriele; Wille, Timo; Musílek, Kamil; Kuča, Kamil; Thiermann, Horst; Worek, Franz: Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase. In: Archives of Toxicology, 2015, roč. 89, č. 3. s. 405-414. IF 5.901.
Hroch, Lukáš; Aitken, Laura; Benek, Ondřej; Doležal, Martin; Kuča, Kamil; Gunn-Moore, Frank; Musílek, Kamil: Benzothiazoles - scaffold of interest for CNS targeted drugs. In: Current Medicinal Chemistry, 2015, roč. 22, č. 6. s. 730-747. IF 3.249.
Janočková, Jana; Plšíková, Jana; Kašpárková, Jana; Brabec, Viktor; Jendželovský, Rastislav; Mikeš, Jaromír; Koval, Ján; Hamulaková, Slávka; Fedoročko, Peter; Kuča, Kamil; Kožurková, Mária: Inhibition of DNA topoisomerases I and II and growth inhibition of HL-60 cells by novel acridine-based compounds. In: European Journal of Pharmaceutical Sciences, 2015, roč. 76, č. August. s. 192-202. IF 3.756.
Klímová, Blanka; Kuča, Kamil: Alzheimer's disease: Potential preventive, non-invasive, intervention strategies in lowering the risk of cognitive decline - A review study. In: Journal of Applied Biomedicine, 2015, roč. 13, č. 4. s. 257-261. IF 1.433.
Klímová, Blanka; Marešová, Petra; Vališ, Martin; Hort, Jakub; Kuča, Kamil: Alzheimer's disease and language impairments: social intervention and medical treatment. In: Clinical interventions in aging [online], 2015, roč. 10, č. Červenec. s. 1401-1408. IF 2.581.
Korábečný, Jan; Andrš, Martin; Nepovimová, Eugenie; Doležal, Rafael; Babková, Kateřina; Horová, Anna; Maliňák, Dávid; Mezeiová, Eva; Górecki, Lukáš; Šepsová, Vendula; Hrabinová, Martina; Soukup, Ondřej; Jun, Daniel; Kuča, Kamil: 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment. In: Molecules, 2015, roč. 20, č. 12. s. 22084-22101. IF 2.861.
Kuča, Kamil; Hrabinová, Martina; Jun, Daniel; Musílek, Kamil; Penhaker, Marek; Krejcar, Ondřej; Soukup, Ondřej: Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE. In: Medicinal Chemistry, 2015, roč. 11, č. 7. s. 683-686. IF 2.331.
Lee, Sang Kwang; Park, Min Kyun; Jhang, Ho Eun; Yi, Jinju; Nahm, Keepyong; Cho, Dae Won; Ra, Choon Sup; Musílek, Kamil; Horová, Anna; Korábečný, Jan; Doležal, Rafael; Jun, Daniel; Kuča, Kamil: Preparation of 7-Methoxy Tacrine Dimer Analogs and Their In vitro/In silico Evaluation as Potential Cholinesterase Inhibitors. In: Bulletin of the Korean Chemical Society, 2015, roč. 36, č. 6. s. 1654-1660. IF 0.602.
Maliňák, Dávid; Gonda, Jozef; Korábečný, Jan; Doležal, Rafael; Honegr, Jan; Soukup, Ondřej; Bužga, Marek; Kuča, Kamil: A Review of the Total Synthesis of (+)-Lactacystin and its Analogs. In: Current Organic Chemistry, 2015, roč. 19, č. 20. s. 1980-2001. IF 1.924.
Marek, Jan; Maliňák, Dávid; Doležal, Rafael; Soukup, Ondřej; Pasdiorová, Markéta; Doležal, Martin; Kuča, Kamil: Synthesis and Disinfection Effect of the Pyridine-4-aldoxime Based Salts. In: Molecules, 2015, roč. 20, č. 3. s. 3681-3696. IF 2.861.
Marešová, Petra; Penhaker, Marek; Selamat, Ali; Kuča, Kamil: The potential of medical device industry in technological and economical context. In: Therapeutics and Clinical Risk Management, 2015, roč. 11, č. Neuveden. s. 1505-1514. IF 2.200.
Marešová, Petra; Mohelská, Hana; Dolejš, Josef; Kuča, Kamil: Socio-economic aspects of Alzheimer's Disease. In: Current Alzheimer Research, 2015, roč. 12, č. 9. s. 903-911. IF 2.952.
Masopust, Jiří; Andrýs, Ctirad; Bažant, Jan; Vyšata, Oldřich; Kuča, Kamil; Vališ, Martin: Anti-NMDA receptor antibodies in patients with a first episode of schizophrenia. In: Neuropsychiatric Disease and Treatment, 2015, roč. 11, č. 2015. s. 619-623. IF 2.198.
Misík, Jan; Pavlíková, Růžena; Cabal, Jiří; Kuča, Kamil: Acute toxicity of some nerve agents and pesticides in rats. In: Drug and Chemical Toxicology, 2015, roč. 38, č. 1. s. 32-36. IF 1.732.
Mohelská, Hana; Marešová, Petra; Vališ, Martin; Kuča, Kamil: Alzheimer's disease and its treatment costs: case study in the Czech Republic. In: Neuropsychiatric Disease and Treatment, 2015, roč. 11, č. September. s. 2349-2354. IF 2.198.
Nepovimová, Eugenie; Korábečný, Jan; Doležal, Rafael; Babková, Kateřina; Ondřejíček, Aleš; Jun, Daniel; Šepsová, Vendula; Horová, Anna; Hrabinová, Martina; Soukup, Ondřej; Bukum, Neslihan; Jošt, Petr; Múčková, Ľubica; Kassa, Jiří; Maliňák, Dávid; Andrš, Martin; Kuča, Kamil: Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity. In: Journal of Medicinal Chemistry, 2015, roč. 58, č. 22. s. 8985-9003. IF 6.259.
Patočka, Jiří; Gupta, Ramesh C.; Wu, Qing-hua; Kuča, Kamil: Toxic potential of palytoxin. In: Journal of Huazhong University of Science and Technology - Medical Science, 2015, roč. 35, č. 5. s. 773-780. IF 0.964.
Pejchal, Jaroslav; Šinkorová, Zuzana; Tichý, Aleš; Kmochová, Adéla; Ďurišová, Kamila; Kubelková, Klára; Pohanka, Miroslav; Bureš, Jan; Tachecí, Ilja; Kuča, Kamil; Vávrová, Jiřina: Attenuation of radiation - induced gastrointestinal damage by epidermal growth factor and bone marrow transplantation in mice. In: International Journal of Radiation Biology, 2015, roč. 91, č. 9. s. 703-714. IF 1.992.
Petroianu, Georg A.; Nurulain, Syed M.; Hasan, Mohamed Y.; Kuča, Kamil; Lorke, Dietrich E.: Reversible cholinesterase inhibitors as pretreatment for exposure to organophosphates: assessment using azinphos-methyl. In: Journal of Applied Toxicology, 2015, roč. 35, č. 5. s. 493-499. IF 3.159.
Sahu, Arvind Kumar; Gupta, Bhanushree; Sharma, Rahul; Singh, Yama; Musílek, Kamil; Kuča, Kamil; Ghosh, Kallol K.: Kinetic and physicochemical analysis of structurally different bis-pyridinium oximes against pesticide inhibited AChE. In: Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry, 2015, roč. 54, č. 1. s. 40-45. IF 0.494.
Sharma, Rahul; Gupta, Bhanushree; Singh, Namrata; Acharya, J. R.; Musílek, Kamil; Kuča, Kamil; Ghosh, Kallol Kumar: Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review. In: Mini-Reviews in Medicinal Chemistry, 2015, roč. 15, č. 1. s. 58-72. IF 2.661.
Singh, Namrata; Karpichev, Yevgen; Tiwari, Amit K.; Kuča, Kamil; Ghosh, Kallol K.: Oxime functionality in surfactant self-assembly: An overview on combating toxicity of organophosphates. In: Journal of Molecular Liquids, 2015, roč. 208, č. August. s. 237-252. IF 3.648.
Šepsová, Vendula; Žďárová Karasová, Jana; Tobin, Gunnar; Jun, Daniel; Korábečný, Jan; Čábelová, Pavla; Janská, Kateřina; Krůšek, Jan; Skřenková, Kristýna; Kuča, Kamil; Valko, Marián; Soukup, Ondřej: Cholinergic properties of new 7-methoxytacrine-donepezil derivatives. In: General Physiology and Biophysics, 2015, roč. 34, č. 2. s. 189-200. IF 1.170.
Špilovská, Katarína; Korábečný, Jan; Horová, Anna; Musílek, Kamil; Nepovimová, Eugenie; Drtinová, Lucie; Gazová, Zuzana; Siposová, Katarína; Doležal, Rafael; Jun, Daniel; Kuča, Kamil: Design, synthesis and in vitro testing of 7-methoxytacrine-amantadine analogues: a novel cholinesterase inhibitors for the treatment of Alzheimer's disease. In: Medicinal Chemistry Research, 2015, roč. 24, č. 6. s. 2645-2655. IF 1.277.
Žunec, Suzana; Radić, Božica; Kuča, Kamil; Musílek, Kamil; Vrdoljak, Ana Lucic: Comparative determination of the efficacy of bispyridinium oximes in paraoxon poisoning. In: Arhiv za Higijenu Rada i Toksikologiju, 2015, roč. 66, č. 2. s. 129-134. IF 1.395.
