Postdoctoral fellow
+420 495 833 195
Michaela.hympanova@fnhk.cz
ORCID: 0000-0003-2926-3798
Michaela obtained her Master degree in 2018 at the Faculty of Pharmacy in Hradec Kralove, Charles University in Prague. Main focus of her master thesis was the Enzyme kinetic evaluation of several potential inhibitors of certain human cysteine and serine proteases.
In 2023 she successfully finished her postgraduate studies at the Faculty of Military Health Sciences, University of Defence and obtained the doctoral degree from Medical microbiology. Within the topic of her dissertation thesis she was focused on antimicrobial susceptibility testing, especially on bacterial biofilm assays. Currently, as postdoctoral fellow at CBV, she continued the research work focused on antimicrobial susceptibility testing of new agents and the study of bacterial resistance.
| PharmDr. | 2024 | Charles University, Faculty of Pharmacy in Hradec Kralove |
| PhD. | 2018–2023 | University of Defence, Faculty of Military Health Sciences, Department of Epidemiology study program: Medical Microbiology Dissertation thesis title: Evaluation of the antimicrobial effect of quaternary ammonium salts |
| MSc. | 2018 | Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Organic Chemistry Diploma thesis title: Enzyme kinetic evaluation of several potential inhibitors of certain human cysteine and serine proteases |
| 2018–today | Researcher, Biomedical Research Center, University Hospital Hradec Kralove |
|
Title: |
MBEC assay: The method modification for individual bacterial strains and multiple-species biofilms |
|
Funding: |
SV/FVZ2019/05 |
|
Schedule: |
2019-2021 |
|
Role: |
Main investigator |
|
Title: |
Oral biofilm model for susceptibility testing of disinfectants |
|
Funding: |
FNHK |
|
Schedule: |
2021 |
|
Role: |
Main investigator |
|
Title: |
Development of novel quaternary ammonium compounds against microbial biofilm in oral cavity |
|
Funding: |
Healthcare Research Agency of Czech Republic |
|
Schedule: |
2019–2022 |
|
Role: |
Team member |
|
Title: |
Pseudomonas aeruginosa resistance targeting |
|
Funding: |
FNHK |
|
Schedule: |
2023 |
|
Role: |
Main investigator |
| 9/2019–12/2019 | Internship in Slovenia within the project Erasmus+, University of Ljubljana, Biotechnical Faculty, Chair of Microbiology – Prof. D. Stopar’s research group |
| 9/2017–1/2018 | Internship in Germany within the project Erasmus+, University of Bonn, Pharmaceutical Institute, Department of Pharmaceutical Chemistry – Prof. M. Gütschow’s research group |
2023
Finger V, Kucera T, Kafkova R, Muckova L, Dolezal R, Kubes J, Novak M, Prchal L, Lakatos L, Andrs M, Hympanova M, Marek J, Kufa M, Spiwok V, Soukup O, Mezeiova E, Janousek J, Nevosadova L, Benkova M, Kitson RRA, Kratky M, Bősze S, Mikusova K, Hartkoorn R, Roh J, Korabecny J. 2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1. Eur J Med Chem. 2023 Oct 5;258:115611. doi: 10.1016/j.ejmech.2023.115611. Epub 2023 Jul 3. PMID: 37421887. IF(2022) 6,7
2022
Hympanova, M., C. Oliver-Urrutia, M. Vojta, M. Macháček, P. Krupka, R. Kukla, L. Celko, E.B. Montufar a J. Marek. Assessment of Streptococcus mutans biofilm formation on calcium phosphate ceramics: The role of crystalline composition and microstructure. Biomater. Adv. 135, 212750 (2022). doi:10.1016/j.bioadv.2022.212750. IF(2022) 7,3
Terlep, S., M. Hympanova, I. Dogša, F. Pajk a D. Stopar. Photoacoustic removal of E. faecalis biofilms from titanium surface with an Er:YAG laser using Super Short Pulse, LIMS. 37 (1), (2022). doi:10.1007/s10103-021-03265-6. IF(2021) 3,2
2021
Markova, A., M. Hympanova, M. Matula, L. Prchal, R. Sleha, M. Benkova, L. Pulkrabkova, O. Soukup, Z. Krocova, D. Jun a J. Marek. Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts. Toxics. 9, 222 (2021). doi: 10.3390/toxics9090222. IF(2021) 4,2
2020
Hympanova, M., S. Terlet, A. Markova, L. Prchal, I. Dogša, L. Pulkrabkova, M. Benkova, J. Marek a D. Stopar. The Antibacterial Effects of New N-Alkylpyridinium Salts on Planktonic and Biofilm Bacteria. Front. Microbiol. 11, 573951 (2020). doi:10.3389/fmicb.2020.573951. IF(2020) 5,6
Soukup, O., M. Benkova, R. Dolezal, R. Sleha, D. Malinak, S. Salajkova, A. Markova, M. Hympanova, L. Prchal, L. Ryskova, L. Hobzova, K. Sepčić, N. Gunge-Cimerman, J. Korabecny, D. Jun, V. Bostikova, P. Bostik a J. Marek. The wide-spectrum antimicrobial effect of novel N-alkyl monoquaternary ammonium salts and their mixtures; the QSAR study against bacteria. Eur. J. Med. Chem. 206, 112584, (2020). doi: 10.1016/j.ejmech.2020.112584. IF(2020) 6,5
