Postdoctoral fellow
lubkamuckova@gmail.com
ORCID: 0000-0001-6693-6061
Ľubica obtained her Ph.D. degree in 2020 in the study program Toxicology at the Faculty of Military Health Sciences, University of Defence. The theme of her dissertation thesis was „In vitro characterization of compounds modulating acetylcholinesterase activity“. Currently, she works as research and development fellow at the Biomedical Research Centre in the biochemical group. She is an assistant professor in the Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, the University of Defence at the same time.
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RNDr. |
(2021) |
Charles University in Prague, Faculty of Pharmacy, study program Biochemistry |
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Ph.D. |
(2014–today) |
University of Defence in Brno, Faculty of Military Health Sciences, study program Toxicology |
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Mgr. |
(2014) |
Charles University in Prague, Faculty of Pharmacy, study program Medical bioanalytics |
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Bc. |
(2012) |
Alexander Dubček University of Trenčín, Faculty of Healthcare, Department of Laboratory Medicine |
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2021 |
Lector of biochemical laboratory practices at the Faculty of Medicine in Hradec Kralove, Charles University |
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January 2020–today |
Instructor, Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences |
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2019–today |
Researcher, Biomedical Research Center, University Hospital Hradec Kralove |
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2018–2019 |
Instructor, Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences |
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2020 |
Faculty of Military Health Sciences Dean’s award for scientific contribution in 2020 |
Author or co-author 26 scientific publications with IF
Citation: 234 (excluding self-citations)
H-index: 8
Mamun, Abdullah Al, Filip Pidaný, Daniela Hulcová, Jana Maříková, Tomáš Kučera, Lubica Múčková, Maria Carmen Catapano, et al. „Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies". International Journal of Molecular Sciences 22, č. 15 (leden 2021): 8308. https://doi.org/10.3390/ijms22158308.
Mezeiova, Eva, Jana Janockova, Rudolf Andrys, Ondrej Soukup, Tereza Kobrlova, Lubica Muckova, Jaroslav Pejchal, et al. „2-Propargylamino-Naphthoquinone Derivatives as Multipotent Agents for the Treatment of Alzheimer’s Disease". European Journal of Medicinal Chemistry 211 (5. únor 2021): 113112. https://doi.org/10.1016/j.ejmech.2020.113112.
Jost, Petr, Lubica Muckova, a Jaroslav Pejchal. „In Vitro Stress Response Induced by Sulfur Mustard in Lung Fibroblasts NHLF and Human Pulmonary Epithelial Cells A-549". Archives of Toxicology 94, č. 10 (1. říjen 2020): 3503–14. https://doi.org/10.1007/s00204-020-02845-9.
Zdarova Karasova, Jana, Vendula Hepnarova, Rudolf Andrys, Miroslav Lisa, Petr Jost, Lubica Muckova, Jaroslav Pejchal, et al. „Encapsulation of Oxime K027 into Cucurbit[7]Uril: In Vivo Evaluation of Safety, Absorption, Brain Distribution and Reactivation Effectiveness". Toxicology Letters 320 (1. březen 2020): 64–72. https://doi.org/10.1016/j.toxlet.2019.11.021.
Muckova, L., N. Vanova, J. Misik, D. Herman, J. Pejchal, and D. Jun. 2019. ‘Oxidative Stress Induced by Oxime Reactivators of Acetylcholinesterase in Vitro’. Toxicology in Vitro 56 (April): 110–17. https://doi.org/10.1016/j.tiv.2019.01.013.
Muckova, Lubica, Jaroslav Pejchal, Petr Jost, Nela Vanova, David Herman, and Daniel Jun. 2019. ‘Cytotoxicity of Acetylcholinesterase Reactivators Evaluated in Vitro and Its Relation to Their Structure’. Drug and Chemical Toxicology 42 (3): 252–56. https://doi.org/10.1080/01480545.2018.1432641.
Gorecki, Lukas, Lucie Junova, Tomas Kucera, Vendula Hepnarova, Lukas Prchal, Tereza Kobrlova, Lubica Muckova, Ondrej Soukup, and Jan Korabecny. 2019. ‘Tacroximes: Novel Unique Compounds for the Recovery of Organophosphorus-Inhibited Acetylcholinesterase’. Future Medicinal Chemistry, September. https://doi.org/10.4155/fmc-2019-0027.
Hepnarova, V., J. Korabecny, L. Matouskova, P. Jost, L. Muckova, M. Hrabinova, N. Vykoukalova, et al. 2018. ‘The Concept of Hybrid Molecules of Tacrine and Benzyl Quinolone Carboxylic Acid (BQCA) as Multifunctional Agents for Alzheimer’s Disease’. European Journal of Medicinal Chemistry 150 (April): 292–306. https://doi.org/10.1016/j.ejmech.2018.02.083.
Mezeiova, Eva, Jan Korabecny, Vendula Sepsova, Martina Hrabinova, Petr Jost, Lubica Muckova, Tomas Kucera, et al. 2017. ‘Development of 2-Methoxyhuprine as Novel Lead for Alzheimer’s Disease Therapy’. Molecules 22 (8): 1265. https://doi.org/10.3390/molecules22081265.
Nepovimova, Eugenie, Jan Korabecny, Rafael Dolezal, Thuy Duong Nguyen, Daniel Jun, Ondrej Soukup, Marketa Pasdiorova, Lubica Muckova, et al. 2016. ‘7-Methoxytacrine – 4-Pyridinealdoxime Hybrid as Novel Prophylactic Agent with Reactivation Properties in Organophosphate Intoxications’. Toxicology Research, May. https://doi.org/10.1039/C6TX00130K.
Nepovimova, Eugenie, Jan Korabecny, Rafael Dolezal, Katerina Babkova, Ales Ondrejicek, Daniel Jun, Vendula Sepsova, Lubica Muckova, et al. 2015. ‘Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity’. Journal of Medicinal Chemistry 58 (22): 8985–9003. https://doi.org/10.1021/acs.jmedchem.5b01325.
