Ľubica obtained her Master degree in 2014 in the study program Medical bioanalytics at the Faculty of Pharmacy in Hradec Kralove, Charles University in Prague. The theme of her diploma thesis was „Laboratory diagnostics of kidney injury in patients with diabates mellitus I and II “. Currently, Ľubica is a student of doctoral degree program Toxicology at the Faculty of Military Health Sciences in Hradec Kralove, University of Defence in Brno, and simultaneously she works as a researcher at the Biomedical Research Center and as Instructor at Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence.
|Ph.D.||(2014–today)||University of Defence in Brno, Faculty of Military Health Sciences, study program Toxicology
Dissertation title: In vitro characterization of compounds modulating activity of acetylcholinesterase
|Mgr.||(2014)||Charles University in Prague, Faculty of Pharmacy, study program Medical bioanalytics
Diploma Thesis title: Laboratory diagnostics of kidney injury in patients with diabates mellitus I and II
|Bc.||(2012)||Alexander Dubček University of Trenčín, Faculty of Healthcare, Department of Laboratory Medicine
Bachelor Thesis title: Cystatin C- a marker of kidney damage in patients with diabetes
|January 2020– today||Instructor, Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences|
|2019–today||Researcher, Biomedical Research Center, University Hospital Hradec Kralove|
|2018–2019||Instructor, Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences|
Author or co-author 15 scientific publications with IF
Citation: 136 (excluding self-citations)
Muckova, L., N. Vanova, J. Misik, D. Herman, J. Pejchal, and D. Jun. 2019. ‘Oxidative Stress Induced by Oxime Reactivators of Acetylcholinesterase in Vitro’. Toxicology in Vitro 56 (April): 110–17. https://doi.org/10.1016/j.tiv.2019.01.013.
Muckova, Lubica, Jaroslav Pejchal, Petr Jost, Nela Vanova, David Herman, and Daniel Jun. 2019. ‘Cytotoxicity of Acetylcholinesterase Reactivators Evaluated in Vitro and Its Relation to Their Structure’. Drug and Chemical Toxicology 42 (3): 252–56. https://doi.org/10.1080/01480545.2018.1432641.
Chalupova, Katarina, Jan Korabecny, Manuela Bartolini, Barbara Monti, Doriano Lamba, Rosanna Caliandro, Alessandro Pesaresi, Lubica Muckova et al. 2019. ‘Novel Tacrine-Tryptophan Hybrids:
Multi-Target Directed Ligands as Potential Treatment for Alzheimer’s Disease’. European Journal of Medicinal Chemistry 168 (April): 491–514. https://doi.org/10.1016/j.ejmech.2019.02.021.
Gorecki, Lukas, Lucie Junova, Tomas Kucera, Vendula Hepnarova, Lukas Prchal, Tereza Kobrlova, Lubica Muckova, Ondrej Soukup, and Jan Korabecny. 2019. ‘Tacroximes: Novel Unique Compounds for the Recovery of Organophosphorus-Inhibited Acetylcholinesterase’. Future Medicinal Chemistry, September. https://doi.org/10.4155/fmc-2019-0027.
Hepnarova, Vendula, Lubica Muckova, Avi Ring, Jaroslav Pejchal, David Herman, Jan Misik, Martina Hrabinova, Daniel Jun, and Ondrej Soukup. 2019. ‘Pharmacological and Toxicological in Vitro and in Vivo Effect of Higher Doses of Oxime Reactivators’. Toxicology and Applied Pharmacology, October, 114776. https://doi.org/10.1016/j.taap.2019.114776.
Hepnarova, V., J. Korabecny, L. Matouskova, P. Jost, L. Muckova, M. Hrabinova, N. Vykoukalova, et al. 2018. ‘The Concept of Hybrid Molecules of Tacrine and Benzyl Quinolone Carboxylic Acid (BQCA) as Multifunctional Agents for Alzheimer’s Disease’. European Journal of Medicinal Chemistry 150 (April): 292–306. https://doi.org/10.1016/j.ejmech.2018.02.083.
Mezeiova, Eva, Jan Korabecny, Vendula Sepsova, Martina Hrabinova, Petr Jost, Lubica Muckova, Tomas Kucera, et al. 2017. ‘Development of 2-Methoxyhuprine as Novel Lead for Alzheimer’s Disease Therapy’. Molecules 22 (8): 1265. https://doi.org/10.3390/molecules22081265.
Nepovimova, Eugenie, Jan Korabecny, Rafael Dolezal, Thuy Duong Nguyen, Daniel Jun, Ondrej Soukup, Marketa Pasdiorova, Lubica Muckova, et al. 2016. ‘7-Methoxytacrine – 4-Pyridinealdoxime Hybrid as Novel Prophylactic Agent with Reactivation Properties in Organophosphate Intoxications’. Toxicology Research, May. https://doi.org/10.1039/C6TX00130K.
Nepovimova, Eugenie, Jan Korabecny, Rafael Dolezal, Katerina Babkova, Ales Ondrejicek, Daniel Jun, Vendula Sepsova, Lubica Muckova, et al. 2015. ‘Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity’. Journal of Medicinal Chemistry 58 (22): 8985–9003. https://doi.org/10.1021/acs.jmedchem.5b01325.