Janoušek Jiří | Centrum biomedicínského výzkumu

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Janoušek Jiří

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For Czech version click here

Postdoctoral fellow
+420 495 832 502
jiri.janousek@fnhk.cz
ORCID: 0000-0002-3336-3874


Jiří obtained his Ph.D. in 2019 at the Dpt. of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University. His dissertation thesis was focus on the radiolabeling of monoclonal antibodies for in vivo tumor imaging. Currently, he is a part-time researcher at the Biomedical Research Center, University Hospital Hradec Kralove. Besides the scientific activity, he is devoted to teaching and supervising pre-gradual students at the Faculty of Pharmacy in Hradec Kralove.

 

 

Education

Ph.D. 

(2019)

Charles University, Faculty of Pharmacy in Hradec Kralove
Dissertation thesis: The study of properties of radiolabelled monoclonal antibodies for imaging in oncology

PharmDr.  

(2019)

Charles University, Faculty of Pharmacy in Hradec Kralove

Mgr.  

(2014)

Charles University, Faculty of Pharmacy in Hradec Kralove

 

Professioinal Training

 2020–present

Biomedical Research Center, University Hospital Hradec Kralove 

 2019–present

Assistant Professor, Dpt. of Pharmacognosy, Charles University, Faculty of Pharmacy in Hradec Kralove

 2014

Entitled to work with laboratory animals according the Law 246/1992 Sb.

 2014–2019

Ph.D. student, Dpt. of Pharmacology and Toxicology, Charles University, Faculty of Pharmacy in HK

 

Projects

Title:  Radiolabeled ramucirumab for targeted radiotherapy and molecular imaging and its in vitro biological evaluation
Funding:   Charles University Grant Agency No. 998216/C/2016
Schedule:   2016–2019
Role:  main researcher

 

Education activities

2019–present

Lecturer of Pharmacognosy, Faculty of Pharmacy, Charles University
Lecturer of Technology of Natural Drugs, Faculty of Pharmacy, Charles University

2015–2018

Lecturer of Radiopharmaceuticals, Faculty of Pharmacy, Charles University

 

Publication activity

Author or co-author of 9 scientific publications with IF

H-index: 3

(dated 03/2020)

 

Selected publications

2020

Juhas, M., Kucerova, L., Horacek, O., Jandourek, O., Kubicek, V., Konecna, K., Kucera, R., Barta, P., Janousek, J., Paterova, P., Kunes, J., Dolezal, M., Zitko, J.: N-Pyrazinoyl Substituted Amino Acids as Potential Antimycobacterial Agents—the Synthesis and Biological Evaluation of Enantiomers. Molecules 25, article number: 1518 (2020).

BOUZ, G., JUHAS, M., PAUSAS OTERO, L., PAREDES DE LA RED, C., JANDOUREK, O., KONECNA, K., PATEROVA, P., KUBICEK, V., JANOUSEK, J., DOLEZAL, M., ZITKO, J: Substituted N-(Pyrazin-2-yl) benzenesulfonamides; Synthesis, Anti-Infective Evaluation, Cytotoxicity, and In Silico Studies. Molecules 25, article number: 138 (2020).

KRATKY, M., KONECNA, K., JANOUSEK, J., BRABLIKOVA, M., JANDOUREK, O., TREJTNAR, F., STOLARIKOVA, J., VINSOVA, J: 4-Aminobenzoic Acid Derivatives: Converting Folate Precursor to Antimicrobial and Cytotoxic Agents. Biomolecules 10, article number: 9 (2020).

2019

JANOUSEK, J., BARTA, P., NOVY, Z., ZILKOVA, K., TREJTNAR, F: Antiangiogenic Human Monoclonal Antibody Ramucirumab Radiolabelling: In Vitro Evaluation on VEGFR2-positive Cell Lines. Anticancer Res. 39, 735-744 (2019).

2018

VOSATKA, R., KRATKY, M., SVARCOVA, M., JANOUSEK, J., STOLARIKOVA, J., MADACKI, J., HUSZAR, S., MIKUSOVA, K., KORDULAKOVA, J., TREJTNAR, F., VINŠOVÁ, J: New lipophilic isoniazid derivatives and their 1, 3, 4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action. Eur. J. Med. Chem. 151, 824-835 (2018).

ZITKO, J., MINDLOVA, A., VALASEK, O., JANDOUREK, O., PATEROVA, P., JANOUSEK, J., KONECNA, K., DOLEZAL, M: Design, Synthesis and Evaluation of N-pyrazinylbenzamides as Potential Antimycobacterial Agents. Molecules 23, article number: 2390 (2018).

2017

BARTA, P., JANOUSEK, J., ZILKOVA, K., TREJTNAR, F: In vitro evaluation of concentration, labeling effectiveness and stability for 131I‐labeled radioimmunoassay ligand using real‐time detection technology. J. Label. Compd. Radiopharm. 60, 80-86 (2017).

BOUZ, G., JUHAS, M., NIKLOVA, P., JANDOUREK, O., PATEROVA, P., JANOUSEK, J., TUMOVA, L., KOVALIKOVA, Z., KASTNER, P., DOLEZAL, M., ZITKO, J: Ureidopyrazine Derivatives: Synthesis and Biological Evaluation as Anti-Infectives and Abiotic Elicitors. Molecules 22, article number: 1797 (2017). 


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