Postdoctoral fellow
+420 495 833 447
marekjanmgr@seznam.cz
ORCID: 0000-0003-3708-0967
Jan received his PhD in 2012 from the University of Defence in Hradec Kralove. The main aim of his thesis was the preparation and testing of quaternary nitrogen compounds as a disinfectant and decontaminant agents. In the years 2012-2015 he got postdoc position at Charles University, Faculty of Pharmacy in Hradec Kralove. He dealt with preparation of the other compounds acting against microorganisms (disinfectants, antituberculotics). He currently acts at CBV as a postdoc and at the Department of Epidemiology, Faculty of Military Health Sciences, University of Defence as an assistant professor. He continues to prepare and test compounds with a disinfectant effect. Furthermore, he is currently directed on the preparation of potential radioprotective agents and the optimization of cholinesterase reactivators. He also deals with leading and teaching students.
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Ph.D. |
(2012) |
University of Defense, Faculty of Military Health Sciences, Department of Toxicology |
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Dissertation thesis title: Preparation and tests of quaternary nitrogen compounds. |
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PharmDr. |
(2012) |
Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Pharmacology and Toxicology |
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Mgr. |
(2007) |
Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Organic Chemistry |
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Diploma thesis title: Detergents based on quaternary nitrogen heterocycles |
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2015–today |
Postdoc, Biomedical Research Center, Faculty Hospital Hradec kralove |
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2012–2015 |
Postdoc, Department of Pharmaceutical Chemistry and Drug Analysis, Faculty of Pharmacy, Charles University |
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2011–today |
Research fellow, Department ofepidemiology, Faculty of Military Health Sciences, University of Defense |
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2008–2009 |
Lecturing of Organic Chemistry, Department of Chemistry, Faculty of Science, University of J. E. Purkynje in Usti nad Labem |
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2007–2013 |
Research fellow,Department ofToxicology, Faculty of Military Health Sciences, University of Defense |
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2007–2013 |
Research fellow, Vakos XT a.s., Chemprotects.r.o., Decomkova.s., Praha – synthesis of AChE optimization |
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2014-2015 |
Institut of Structural Biology (IBS), Grenoble, Francie – Molecular design, molecular docking (6 months total) |
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2013 |
Course of working in Biosafety level 3/4, Department of Virology, University Medical Center, Goettingen, Germany (1 week) |
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2009 |
DSO national laboratories, Singapore – synthesis of AChE reactivators (1 month) |
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2009 |
University of Gothenburg, Sahlgrenska Academy, Department of Pharmacology (3 month-Erasmus) |
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Title: |
Developmentof novel decontaminants and disinfectantsof skin based on micellar compounds |
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Funding: |
Ministry of Defense OVUOFVZ200803 |
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Schedule: |
2008–2011 |
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Role: |
Member of a team |
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Title: |
Long term development plan 1011 |
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Funding: |
Ministry of Defense |
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Schedule: |
2012–2017 |
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Role: |
Member of a team |
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Title: |
Development of novel disinfectants against pathogens occurring in the hospital environment |
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Funding: |
Healthcare Research Agency of Czech Republic |
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Schedule: |
2015–2018 |
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Role: |
Member of a team |
| Title: | Long term development plan 1011, health issues of weapons of mass destruction |
| Funding: | Ministry of Defense |
| Schedule: | 2017–2020 |
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Role: |
Member of a team |
| Title: | Development of novel radioprotective agents based on small molecule inhibitors |
| Funding: | Grant agency of the Czech republic |
| Schedule: | 2017–2019 |
| Role: | Main co-investigator |
| Title: | Development of polyvalent decontamination mean |
| Funding: | Healthcare Research Agency of Czech Republic |
| Schedule: | 2018–2021 |
| Role: | Main co-investigator |
| Title: | Development of novel quaternary ammonium compounds against microbial biofilm in oral cavity |
| Funding: | Healthcare Research Agency of Czech Republic |
| Schedule: | 2019–2022 |
| Role: | Main investigator |
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2008–today |
Pt. Ravishankar Shukla University, School of Studies in Chemistry, Raipur, India |
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2013–today |
Département de Toxicologie et RisqueChimique, Institut de RechercheBiomédicale des Armées, BP73, F-91223 Brétigny-sur-Orge, Francie |
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2007–2008 |
RůženaPavlíková, diploma thesis, consultant |
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2008–2009 |
Karel Musil, bachelor thesis, supervisor |
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2008–2009 |
Michaela Stolínová, bachelor thesis, supervisor |
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2008–2009 |
Hana Málková, bachelor thesis, supervisor |
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2010–2011 |
LenkaSlavětinská, diploma thesis, consultant |
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2012–2013 |
Petra Janošcová, diploma thesis, consultant |
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2013–2014 |
VěraJosková, diploma thesis, consultant |
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2014–2015 |
Anna Horová, diploma thesis, supervisor |
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2014–2015 |
Jan Vosátka, diploma thesis, supervisor |
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2011–2012 |
Klára Coufalová, Ph.D. study, consultant |
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2014–today |
Markéta Benková, Ph.D. study, supervisor |
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2015–today |
Aneta Nechanická, diploma thesis, supervisor |
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2017–2018 |
Kateřina Pekařová, diploma thesis, consultant |
| 2018–2020 | Ondřej Suk, diploma thesis, consultant |
| 2018–2019 | Natálie Živná, bachelor thesis, consultant |
| 2017–today | Aneta Marková, Ph.D. study, consultant |
| 2018–today | Michaela Hympánová, Ph.D. study, supervisor |
| 2019–today | Hana Straková, diploma thesis, consultant |
| 2020–today | Jana Heinrichová, diploma thesis, consultant |
| 2019–today | Natálie Živná, diploma thesis, consultant |
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2008–2009 |
Keeping practical exercises in Organic Chemistry, Faculty of Science, University of J. E. Purkynje in Usti nad Labem |
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2012–2015 |
Lecturing of Pharmaceutical Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University |
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2011–today |
Military courses lecturing, Faculty of Military Health Sciences, University of Defense |
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2011–today |
Hygiene and epidemiology lecturing, Faculty of Military Health Sciences and Faculty of Medicine in Hradec Kralove |
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2012 |
Nominee for a Prize of the Mayor of Hradce Kralove for research activities |
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2013 |
Awarded by the Medal of Hradce Kralove for research activities |
(dated 4/2020)
2020
Filipova, A.; Marek, J.; Havelek, R.; Pejchal, J.; Jelikoca, M.; Cizkova, J.; Majorosova, M.; Muckova, L.; Kucera, T.; Prchal, L.; Psotka, M.; Zivna, N.; Koutova, D.; Sinkorova, Z.; Rezacova, M.; Tichy, A. Substituted Piperazines as Novel Potential Radiopúrotective Agents. Molecules 2020, 25 (3), in press
Marek, J.; Tichy, A.; Havelek, R.; Seifrtova, M.; Filipova, A.; Andrejsova, L.; Kucera, T.; Muckova, L.; Rezacova, M.; Sinkorova, Z.; Pejchal, J. A novel class of small molecule inhibitors with radioprotective properties. Eur J Med Chem 2020, 187, in press
2019
Benkova, M.; Soukup, O.; Prchal, L.; Sleha, R.; Elersek, T.; Novak, M.; Sepcic, K.; Gunde-Cimerman, N.; Dolezal, R.; Bostik, V.; Bostik, P.; Marek, J. Synthesis, Antimicrobial Effect and Lipophilicity-Activity Dependence of Three Series of Dichained N-Alkylammonium Salts. CHEMISTRYSELECT 2019, 4 (41), 12076-12084
2018
Tichy, A.; Marek, J.; Havelek, R.; Pejchal, J.; Seifrtova, M.; Zarybnicka, L.; Filipova, A.; Rezacova, M.; Sinkorova, Z. New Light on an Old Friend: Targeting PUMA in Radioprotection and Therapy of Cardiovascular and Neurodegenerative Diseases. Curr Drug Targets 2018, 19 (16), 1943-1957
Marek, J.; Joskova, V.; Dolezal, R.; Soukup, O.; Benkova, M.; Fucikova, A.; Malinak, D.; Bostikova, V.; Kuca, K. Synthesis, Antimicrobial Effect and Surface Properties of Hydroxymethyl-substituted Pyridinium Salts. Lett Drug Des Discov 2018, 15 (8), 828-842
2016
Sharma, R.; Gupta, B.; Yadav, T.; Sinha, S.; Sahu, AK.; Karpichev, Y.; Gathergood, N.; Marek, J.; Kuca, K.; Ghosh, KK. Degradation of Organophosphate Pesticides Using Pyridinium Based Functional Surfactants. ACS Sustain Chem Eng 2016, 4 (12), 6962-6973
Dolezal, R.; Soukup, O.; Malinak, D.; Savedra, RML.; Marek, J.; Dolezalova, M.; Pasdiorova, M.; Salajkova, S.; Korabecny, J.; Honegr, J.; Ramalho, TC.; Kuca, K. Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies. Eur J Med Chem 2016, 121, 699-711
2015
Zitko, J.; Servusova, B.; Janoutova, A.; Paterova, P.; Mandikova, J.; Garaj, V.; Vejsova, M.; Marek, J.; Dolezal, M. Synthesis and antimycobacterial evaluation of 5-alkylamino-N-phenylpyrazine-2-carboxamides. Bioorganic and Medicinal Chemistry 2015, 23 (1), 174-183
Marek, J.; Malinak, D.; Dolezal, R.; Soukup, O.; Pasdiorova, M.; Dolezal, M.; Kuca, K. Synthesis and Disinfection Effect of the Pyridine-4-aldoxime Based Salts. Molecules 2015, 20 (3), 3681-3696
2014
Malinak, D.; Dolezal, R.; Marek, J.; Salajkova, S.; Soukup, O.; Vejsova, M.; Korabecny, J.; Honegr, J.; Penhaker, M.; Musilek, K.; Kuca, K. 6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activity. Bioorganic and Medicinal Chemistry Letters 2014, 24 (22), 5238-5241 (IF=2,331)
2013
Singh, N.; Karpichev, Y.; Gupta, B.; Satnami, ML.; Marek, J.; Kuca, K.; Ghosh, KK. Physicochemical Properties and Supernucleophilicity of Oxime-Functionalized Surfactants: Hydrolytic Catalysts toward Dephosphorylation of Di and Triphosphate Esters. Journal of Physical Chemistry B 2013, 117 (14), 3806-3817
2012
Marek, J., Stodulka, P., Cabal, J., Komloova, M., Kuca, K. Preparation of the Quinolinium Salts Differing in the Length of Side Alkylating Chain, Molecules, 2012, 17(6), 6386-6394
Singh, N.; Ghosh, KK.; Marek, J.; Kuca, K. Effect of some pyridinium based compounds on the hydrolysis of carboxylate ester. Indian Journal of Chemistry section B – organic chemistry including medicinal chemistry 2012,51(4), 611-616
2011
Musilek, K.; Pavlikova, R.; Marek, J.; Komloova, M.; Holas, O.; Hrabinova, M.; Pohanka, M.; Dohnal, V.; Dolezal, M.; Gunn-Moore, F.; Kuca, K. The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage. Journal of Enzyme Inhibition and Medicinal Chemistry 2011, 26 (2), 245-253.
Singh, N.; Ghosh, K. K.; Marek, J.; Kuca, K. Hydrolysis of Carboxylate and Phosphate Esters Using Monopyridinium Oximes in Cationic Micellar Media. International Journal of Chemical Kinetics 2011, 43 (10), 569-578.
2010
Marek, J.; Stodulka, P.; Cabal, J.; Soukup, O.; Pohanka, M.; Korabecny, J.; Musilek, K.; Kuca, K. Preparation of the Pyridinium Salts Differing in the Length of the N-Alkyl Substituent. Molecules 2010, 15 (3), 1967-1972.
Tiwari, S.; Ghosh, K. K.; Marek, J.; Kuca, K. Spectrophotometric Determination of the Acidity Constants of Some Oxime-Based alpha-Nucleophiles. Journal of Chemical and Engineering Data 2010, 55 (3), 1153-1157.
