Marek Jan | Centrum biomedicínského výzkumu

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Marek Jan

Info

For Czech version click here

Postdoctoral fellow
+420 495 833 447
marekjanmgr@seznam.cz
ORCID: 0000-0003-3708-0967


 


 


Jan received his PhD in 2012 from the University of Defence in Hradec Kralove. The main aim of his thesis was the preparation and testing of quaternary nitrogen compounds as a disinfectant and decontaminant agents. In the years 2012-2015 he got postdoc position at Charles University, Faculty of Pharmacy in Hradec Kralove. He dealt with preparation of the other compounds acting against microorganisms (disinfectants, antituberculotics). He currently acts at CBV as a postdoc and at the Department of Epidemiology, Faculty of Military Health Sciences, University of Defence as an assistant professor. He continues to prepare and test compounds with a disinfectant effect. Furthermore, he is currently directed on the preparation of potential radioprotective agents and the optimization of cholinesterase reactivators. He also deals with leading and teaching students.

 

Education

Ph.D.

(2012)

University of Defense, Faculty of Military Health Sciences, Department of Toxicology

 

 

Dissertation thesis title: Preparation and tests of quaternary nitrogen compounds.

PharmDr.

(2012)

Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Pharmacology and Toxicology

Mgr.

(2007)

Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Organic Chemistry

 

 

Diploma thesis title: Detergents based on quaternary nitrogen heterocycles

 

Research Focus

  • Quaternary ammonium compounds – synthesis, surface active tests, antimicrobial effect, decontamination effect, biofilm eradication
  • Radioprotective compounds – synthesis, evaluation
  • Acetylcholinesterase (AChE) reactivators – synthesis optimization

 

Professional Training

2015–today

Postdoc, Biomedical Research Center, Faculty Hospital Hradec kralove

2012–2015

Postdoc, Department of Pharmaceutical Chemistry and Drug Analysis, Faculty of Pharmacy, Charles University

2011–today

Research fellow, Department ofepidemiology, Faculty of Military Health Sciences, University of Defense

2008–2009 

Lecturing of Organic Chemistry, Department of Chemistry, Faculty of Science, University of J. E. Purkynje in Usti nad Labem

2007–2013 

Research fellow,Department ofToxicology, Faculty of Military Health Sciences, University of Defense

2007–2013

Research fellow, Vakos XT a.s., Chemprotects.r.o., Decomkova.s., Praha – synthesis of AChE optimization

 

International Experience

2014-2015

Institut of Structural Biology (IBS), Grenoble, Francie – Molecular design, molecular docking (6 months total)

2013 

Course of working in Biosafety level 3/4, Department of Virology, University Medical Center, Goettingen, Germany (1 week)

2009 

DSO national laboratories, Singapore – synthesis of AChE reactivators (1 month)

2009

University of Gothenburg, Sahlgrenska Academy, Department of Pharmacology (3 month-Erasmus)

 

Selected Projects

Title:

Developmentof novel decontaminants and disinfectantsof skin based on micellar compounds

Funding:

Ministry of Defense OVUOFVZ200803

Schedule:

2008–2011

Role:

Member of a team

 

 

Title:

Long term development plan 1011

Funding:

Ministry of Defense

Schedule:

2012–2017

Role:

Member of a team

 

 

Title:

Development of novel disinfectants against pathogens occurring in the hospital environment

Funding:

Healthcare Research Agency of Czech Republic

Schedule:

2015–2018

Role:

Member of a team

   
Title: Long term development plan 1011,  health issues of weapons of mass destruction
Funding: Ministry of Defense
Schedule: 2017–2020

Role:

Member of a team

   
 Title:  Development of novel radioprotective agents based on small molecule inhibitors
 Funding:  Grant agency of the Czech republic 
 Schedule:  2017–2019
 Role:  Main co-investigator
   
 Title:  Development of polyvalent decontamination mean
 Funding:  Healthcare Research Agency of Czech Republic
 Schedule:  2018–2021
 Role:  Main co-investigator
   
Title: Development of novel quaternary ammonium compounds against microbial biofilm in oral cavity
Funding: Healthcare Research Agency of Czech Republic
Schedule: 2019–2022
 Role: Main investigator

 

Cooperation

2008–today

Pt. Ravishankar Shukla University, School of Studies in Chemistry, Raipur, India

2013–today

Département de Toxicologie et RisqueChimique, Institut de RechercheBiomédicale des Armées, BP73, F-91223 Brétigny-sur-Orge, Francie

 

Student supervising and educational activities

2007–2008

RůženaPavlíková, diploma thesis, consultant

2008–2009

Karel Musil, bachelor thesis, supervisor

2008–2009

Michaela Stolínová, bachelor thesis, supervisor

2008–2009

Hana Málková, bachelor thesis, supervisor

2010–2011

LenkaSlavětinská, diploma thesis, consultant

2012–2013

Petra Janošcová, diploma thesis, consultant

2013–2014

VěraJosková, diploma thesis, consultant

2014–2015

Anna Horová, diploma thesis, supervisor

2014–2015

Jan Vosátka, diploma thesis, supervisor

2011–2012

Klára Coufalová, Ph.D. study, consultant

2014–today

Markéta Benková, Ph.D. study, supervisor

2015–today

Aneta Nechanická, diploma thesis, supervisor

2017–2018

Kateřina Pekařová, diploma thesis, consultant

2018–2020 Ondřej Suk, diploma thesis, consultant
2018–2019 Natálie Živná, bachelor thesis, consultant
2017–today Aneta Marková, Ph.D. study, consultant
2018–today Michaela Hympánová, Ph.D. study, supervisor
2019–today Hana Straková, diploma thesis, consultant
2020–today Jana Heinrichová, diploma thesis, consultant
2019–today Natálie Živná, diploma thesis, consultant
   

2008–2009

Keeping practical exercises in Organic Chemistry, Faculty of Science, University of J. E. Purkynje in Usti nad Labem

2012–2015

Lecturing of Pharmaceutical Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University

2011–today

Military courses lecturing, Faculty of Military Health Sciences, University of Defense

2011–today

Hygiene and epidemiology lecturing, Faculty of Military Health Sciences and Faculty of Medicine in Hradec Kralove

 

Awards

2012

Nominee for a Prize of the Mayor of Hradce Kralove for research activities

2013

Awarded by the Medal of Hradce Kralove for research activities

 

Publication Activity

  • Author or co-author of 40 scientific publications with IF
  • Co-author of 2 chapters in book
  • H-index: 14
  • Citations without self-citations: 349

(dated 4/2020)

 

Selected Publications

2020

Filipova, A.; Marek, J.; Havelek, R.; Pejchal, J.; Jelikoca, M.; Cizkova, J.; Majorosova, M.; Muckova, L.; Kucera, T.; Prchal, L.; Psotka, M.; Zivna, N.; Koutova, D.; Sinkorova, Z.; Rezacova, M.; Tichy, A. Substituted Piperazines as Novel Potential Radiopúrotective Agents. Molecules 2020, 25 (3), in press

Marek, J.; Tichy, A.; Havelek, R.; Seifrtova, M.; Filipova, A.; Andrejsova, L.; Kucera, T.; Muckova, L.; Rezacova, M.; Sinkorova, Z.; Pejchal, J. A novel class of small molecule inhibitors with radioprotective properties. Eur J Med Chem 2020, 187, in press

2019

Benkova, M.; Soukup, O.; Prchal, L.; Sleha, R.; Elersek, T.; Novak, M.; Sepcic, K.; Gunde-Cimerman, N.; Dolezal, R.; Bostik, V.; Bostik, P.; Marek, J.  Synthesis, Antimicrobial Effect and Lipophilicity-Activity Dependence of Three Series of Dichained N-Alkylammonium Salts. CHEMISTRYSELECT 2019, 4 (41), 12076-12084

2018

Tichy, A.; Marek, J.; Havelek, R.; Pejchal, J.; Seifrtova, M.; Zarybnicka, L.; Filipova, A.; Rezacova, M.; Sinkorova, Z. New Light on an Old Friend: Targeting PUMA in Radioprotection and Therapy of Cardiovascular and Neurodegenerative Diseases. Curr Drug Targets 2018, 19 (16), 1943-1957

Marek, J.; Joskova, V.; Dolezal, R.; Soukup, O.; Benkova, M.; Fucikova, A.; Malinak, D.; Bostikova, V.; Kuca, K. Synthesis, Antimicrobial Effect and Surface Properties of Hydroxymethyl-substituted Pyridinium Salts. Lett Drug Des Discov 2018, 15 (8), 828-842

2016

Sharma, R.; Gupta, B.; Yadav, T.; Sinha, S.; Sahu, AK.; Karpichev, Y.; Gathergood, N.; Marek, J.; Kuca, K.; Ghosh, KK. Degradation of Organophosphate Pesticides Using Pyridinium Based Functional Surfactants. ACS Sustain Chem Eng 2016, 4 (12), 6962-6973

Dolezal, R.; Soukup, O.; Malinak, D.; Savedra, RML.; Marek, J.; Dolezalova, M.; Pasdiorova, M.; Salajkova, S.; Korabecny, J.; Honegr, J.; Ramalho, TC.; Kuca, K.  Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies. Eur J Med Chem 2016, 121, 699-711

2015

Zitko, J.; Servusova, B.; Janoutova, A.; Paterova, P.; Mandikova, J.; Garaj, V.; Vejsova, M.; Marek, J.; Dolezal, M. Synthesis and antimycobacterial evaluation of 5-alkylamino-N-phenylpyrazine-2-carboxamides. Bioorganic and Medicinal Chemistry 2015, 23 (1), 174-183

Marek, J.; Malinak, D.; Dolezal, R.; Soukup, O.; Pasdiorova, M.; Dolezal, M.; Kuca, K. Synthesis and Disinfection Effect of the Pyridine-4-aldoxime Based Salts. Molecules 2015, 20 (3), 3681-3696

2014

Malinak, D.; Dolezal, R.; Marek, J.; Salajkova, S.; Soukup, O.; Vejsova, M.; Korabecny, J.; Honegr, J.; Penhaker, M.; Musilek, K.; Kuca, K. 6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activity. Bioorganic and Medicinal Chemistry Letters 2014, 24 (22), 5238-5241 (IF=2,331)

2013

Singh, N.; Karpichev, Y.; Gupta, B.; Satnami, ML.; Marek, J.; Kuca, K.; Ghosh, KK. Physicochemical Properties and Supernucleophilicity of Oxime-Functionalized Surfactants: Hydrolytic Catalysts toward Dephosphorylation of Di and Triphosphate Esters. Journal of Physical Chemistry B 2013, 117 (14), 3806-3817

2012

Marek, J., Stodulka, P., Cabal, J., Komloova, M., Kuca, K. Preparation of the Quinolinium Salts Differing in the Length of Side Alkylating Chain, Molecules, 2012, 17(6), 6386-6394

Singh, N.; Ghosh, KK.; Marek, J.; Kuca, K. Effect of some pyridinium based compounds on the hydrolysis of carboxylate ester. Indian Journal of Chemistry section B – organic chemistry including medicinal chemistry 2012,51(4), 611-616

2011

Musilek, K.; Pavlikova, R.; Marek, J.; Komloova, M.; Holas, O.; Hrabinova, M.; Pohanka, M.; Dohnal, V.; Dolezal, M.; Gunn-Moore, F.; Kuca, K. The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage. Journal of Enzyme Inhibition and Medicinal Chemistry 2011, 26 (2), 245-253.

Singh, N.; Ghosh, K. K.; Marek, J.; Kuca, K. Hydrolysis of Carboxylate and Phosphate Esters Using Monopyridinium Oximes in Cationic Micellar Media. International Journal of Chemical Kinetics 2011, 43 (10), 569-578.

2010

Marek, J.; Stodulka, P.; Cabal, J.; Soukup, O.; Pohanka, M.; Korabecny, J.; Musilek, K.; Kuca, K. Preparation of the Pyridinium Salts Differing in the Length of the N-Alkyl Substituent. Molecules 2010, 15 (3), 1967-1972.

Tiwari, S.; Ghosh, K. K.; Marek, J.; Kuca, K. Spectrophotometric Determination of the Acidity Constants of Some Oxime-Based alpha-Nucleophiles. Journal of Chemical and Engineering Data 2010, 55 (3), 1153-1157. 


  • Introduction
  • Our team
    • Team members
    • Andrš Martin
    • Benek Ondřej
    • Benková Markéta
    • Bílková Zuzana
    • Doležal Rafael
    • Fabrik Ivo
    • Fabriková Daniela
    • Finger Vladimír
    • Górecki Lukáš
    • Hatlapatková Jana
    • Hrabinová Martina
    • Hympánová Michaela
    • Chalupová Katarína
    • Janoušek Jiří
    • Junová Lucie
    • Kobrlová Tereza
    • Konečný Jan
    • Korábečný Jan
    • Kuča Kamil
    • Kupčík Rudolf
    • Lenčo Juraj
    • Maliňák Dávid
    • Marek Jan
    • Marková Aneta
    • Mezeiová Eva
    • Múčková Ľubica
    • Musílek Kamil
    • Novák Martin
    • Prchal Lukáš
    • Psotka Miroslav
    • Pulkrábková Lenka
    • Schmidt Monika
    • Soukup Ondřej
    • Svobodová Barbora
    • Tichý Aleš
    • Vajrychová Marie
    • Vaňousová Andrea
  • Laboratories
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  • List of publications
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