Postdoctoral fellow
+420 495 833 447
marekjanmgr@seznam.cz
ORCID: 0000-0003-3708-0967
Jan received his PhD in 2012 at University of Defence in Hradec Kralove. The main aim of histhesis was the preparation and testing of quaternary nitrogen compounds as a disinfectant and decontaminant agents. In the years 2012-2015 he got postdoc position at Charles University, Faculty of Pharmacy in Hradec Kralove. He dealt with preparation of the other compounds acting against microorganisms (disinfectants, antituberculotics). Currently he acts on CBV as a postdoc. He continues designing, preparing and testing of compounds with disinfection affect. He also discusses the leadership and lecturing students (FVZ UO, FaF UK).
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Ph.D. |
(2012) |
University of Defense, Faculty of Military Health Sciences, Department of Toxicology |
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Dissertation thesis title: Preparation and tests of quaternary nitrogen compounds. |
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PharmDr. |
(2012) |
Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Pharmacology and Toxicology |
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Mgr. |
(2007) |
Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Organic Chemistry |
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Diploma thesis title: Detergents based on quaternary nitrogen heterocycles |
Synthesis and in-vitro evaluation of cationic surface active agents as disinfectants and decontaminants, antimicrobial tests, optimization of reactivators AChE
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2015-today |
Postdoc, Biomedical Research Center, Faculty Hospital Hradec kralove |
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2012-2015 |
Postdoc, Department of Pharmaceutical Chemistry and Drug Analysis, Faculty of Pharmacy, Charles University |
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2011-today |
Research fellow, Department ofepidemiology, Faculty of Military Health Sciences, University of Defense |
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2008-2009
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Lecturing of Organic Chemistry, Department of Chemistry, Faculty of Science, University of J. E. Purkynje in Usti nad Labem |
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2007-2013
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Research fellow,Department ofToxicology, Faculty of Military Health Sciences, University of Defense |
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2007-2013 |
Research fellow, Vakos XT a.s., Chemprotects.r.o., Decomkova.s., Praha – synthesis of AChE optimization |
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2014-2015 |
Institut of Structural Biology (IBS), Grenoble, Francie – Molecular design, molecular docking (6 months total) |
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2013
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Course of working in Biosafety level 3/4, Department of Virology, University Medical Center, Goettingen, Germany (1 week) |
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2009
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DSO national laboratories, Singapore – synthesis of AChE reactivators (1 month) |
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2009 |
University of Gothenburg, Sahlgrenska Academy, Department of Pharmacology (3 month-Erasmus) |
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Title: |
Developmentof novel decontaminants and disinfectantsof skin based on micellarcompounds |
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Funding: |
Ministry of Defense OVUOFVZ200803 |
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Schedule: |
2008-2011 |
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Role: |
Member of a team |
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Title: |
Long term development plan 1011 |
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Funding: |
Ministry of Defense |
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Schedule: |
2012-2017 |
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Role: |
Member of a team |
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Title: |
Development of novel disinfectants against pathogens occurring in the hospital environment |
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Funding: |
Healthcare Research Agency of Czech Republic |
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Schedule: |
2015-2018 |
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Role: |
Member of a team |
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2008-today |
Pt. Ravishankar Shukla University, School of Studies in Chemistry, Raipur, India |
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2013-today |
Département de Toxicologie et RisqueChimique, Institut de RechercheBiomédicale des Armées, BP73, F-91223 Brétigny-sur-Orge, Francie |
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2007-2008 |
RůženaPavlíková, diploma thesis, consultant |
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2008-2009 |
Karel Musil, bachelor thesis, supervisor |
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2008-2009 |
Michaela Stolínová, bachelor thesis, supervisor |
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2008-2009 |
Hana Málková, bachelor thesis, supervisor |
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2010-2011 |
LenkaSlavětinská, diploma thesis, consultant |
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2012-2013 |
Petra Janošcová, diploma thesis, consultant |
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2013-2014 |
VěraJosková, diploma thesis, consultant |
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2014-2015 |
Anna Horová, diploma thesis, supervisor |
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2014-2015 |
Jan Vosátka, diploma thesis, supervisor |
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2011-2012 |
KláraCoufalová, Ph.D. study, consultant |
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2014-today |
MarkétaPasdiorová, Ph.D. study, supervisor |
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2015-today |
AnetaNechanická, diploma thesis, supervisor |
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2008-2009 |
Keeping practical exercises in Organic Chemistry, Faculty of Science, University of J. E. Purkynje in Usti nad Labem |
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2012-2015 |
Lecturing of Pharmaceutical Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University |
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2011-today |
Military courses lecturing, Faculty of Military Health Sciences, University of Defense |
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2011-today |
Hygiene and epidemiology lecturing, Faculty of Military Health Sciences and Faculty of Medicine in Hradec Kralove |
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2012 |
Nomineefor a PrizeoftheMayorof Hradce Kraloveforresearchactivities |
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2013 |
Awarded by theMedalof Hradce Kraloveforresearchactivities |
(dated 8/2015)
2015
Zitko, J.; Servusova, B.; Janoutova, A.; Paterova, P.; Mandikova, J.; Garaj, V.; Vejsova, M.; Marek, J.; Dolezal, M. Synthesis and antimycobacterial evaluation of 5-alkylamino-N-phenylpyrazine-2-carboxamides. Bioorganic and Medicinal Chemistry2015, 23 (1), 174-183
Marek, J.; Malinak, D.; Dolezal, R.; Soukup, O.; Pasdiorova, M.; Dolezal, M.; Kuca, K. Synthesis and Disinfection Effect of the Pyridine-4-aldoxime Based Salts. Molecules2015, 20 (3), 3681-3696
Semelkova, L.; Konecna, K.; Paterova, P.; Kubicek, V.; Kunes, J.; Novakova, L.; Marek, J.; Naesens, L.; Pesko, M.; Kralova, K.; Dolezal, M.; Zitko, J. Synthesis and Biological Evaluation of N-Alkyl-3-(alkylamino)-pyrazine-2-carboxamides. Molecules, 2015, 20 (5), 8687-8711
2014
Malinak, D.; Dolezal, R.; Marek, J.; Salajkova, S.; Soukup, O.; Vejsova, M.; Korabecny, J.; Honegr, J.; Penhaker, M.; Musilek, K.; Kuca, K. 6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activity. Bioorganic and Medicinal Chemistry Letters2014, 24 (22), 5238-5241 (IF=2,331)
2013
Singh, N.; Karpichev, Y.; Gupta, B.; Satnami, ML.; Marek, J.; Kuca, K.; Ghosh, KK. Physicochemical Properties and Supernucleophilicity of Oxime-Functionalized Surfactants: Hydrolytic Catalysts toward Dephosphorylation of Di and Triphosphate Esters. Journal of Physical Chemistry B2013, 117 (14), 3806-3817
2012
Marek, J., Stodulka, P., Cabal, J., Komloova, M., Kuca, K. Preparation of the Quinolinium Salts Differing in the Length of Side Alkylating Chain, Molecules, 2012, 17(6), 6386-6394
Singh, N.; Ghosh, KK.;Marek, J.; Kuca, K. Effect of some pyridinium based compounds on the hydrolysis of carboxylate ester. Indian Journal of Chemistry section B – organic chemistry including medicinal chemistry2012,51(4), 611-616
2011
Musilek, K.; Pavlikova, R.; Marek, J.; Komloova, M.; Holas, O.; Hrabinova, M.; Pohanka, M.; Dohnal, V.; Dolezal, M.; Gunn-Moore, F.; Kuca, K. The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage. Journal of Enzyme Inhibition and Medicinal Chemistry2011,26 (2), 245-253.
Singh, N.; Ghosh, K. K.; Marek, J.; Kuca, K. Hydrolysis of Carboxylate and Phosphate Esters Using Monopyridinium Oximes in Cationic Micellar Media. International Journal of Chemical Kinetics2011,43 (10), 569-578.
2010
Korabecny, J.; Musilek, K.; Holas, O.; Binder, J.; Zemek, F.; Marek, J.; Pohanka, M.; Opletalova, V.; Dohnal, V.; Kuca, K. Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorganic & Medicinal Chemistry Letters2010,20 (20), 6093-6095.
Marek, J.; Stodulka, P.; Cabal, J.; Soukup, O.; Pohanka, M.; Korabecny, J.; Musilek, K.; Kuca, K. Preparation of the Pyridinium Salts Differing in the Length of the N-Alkyl Substituent. Molecules2010,15 (3), 1967-1972.
Soukup, O.; Kristofikova, Z.; Proska, J.; Tobin, G.; Patocka, J.; Marek, J.; Jun, D.; Fusek, J.; Ripova, D.; Kuca, K. Novel acetylcholinesterase reactivator K112 and its cholinergic properties. Biomedicine & Pharmacotherapy2010,64 (8), 541-545.
Tiwari, S.; Ghosh, K. K.; Marek, J.; Kuca, K. Spectrophotometric Determination of the Acidity Constants of Some Oxime-Based alpha-Nucleophiles.Journal of Chemical and Engineering Data2010,55 (3), 1153-1157.
