Maliňák Dávid | Centrum biomedicínského výzkumu

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Maliňák Dávid

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Postdoctoral fellow
+420 495 832 502  
david.malinak@gmail.com
ORCID: 0000-0002-0665-0667
Researcher ID: AAH-1337-2020

 


Dávid obtained his PhD in 2013 at the Faculty of Science Pavol Jozef Šafárik University in Košice. The main aim of the thesis was stereocontrolled synthesis of advanced precursor for preparation of (+)-lactacystin. Currently, he is postdoctoral fellow at the Biomedical Research Center (BRC), University Hospital Hradec Kralove, where he dealt with the development of new drugs in the field of adjuvants, nanoparticles, antidotes for organophosphates poisoning, disinfectants and decontamination agents.

 

Education

Ph.D. (2013)

Pavol Jozef Šafárik University in Košice, Faculty of Science

Disertation thesis title: Stereocontrolled synthesis of advanced precursor for preparation of (+)-lactacystin

RNDr. (2010)

Pavol Jozef Šafárik University in Košice, Faculty of Science

Title of thesis: Total synthesis of (+)-lactacystinwith using of Overman [3,3]-sigmatropic rearrangement

Mgr. (2008)

Pavol Jozef Šafárik University in Košice, Faculty of Science

Master thesis title: Heterocumulens of nucleobases as supramolecular building blocks

Bc. (2006)

Pavol Jozef Šafárik University in Košice, Faculty of Science

Bachelor thesis title: Chiral separation technics

 

 

Research Focus

  • Design and synthesis of novel bioactive compounds
  • Structure-activity relationship of bioactive compounds

 

Professional Training

Since 2016 Assist. Professor in Department of Chemistry, Faculty of Science, University of Hradec Králové
Since 2013 Postdoctoral fellow, Biomedical Research Center, University Hospital Hradec Králové
2012–2013 Assist. Professor in Insitute of Chemistry, Faculty of Science UPJŠ in Košice
2012–2013 PhD Study: Faculty of Science UPJŠ in Košice, study: Organic chemistry

 

Projects

Principal investigator – GA21-03000S (2021-2023), FNHK 8114 (2017), VVGS PF 16/2011/Ch, VVGS PF 6/2010/Ch, VVGS PF 20/2009/CH

Team member – GA19-11867S (2019-2021), NV18-05-00562 (2018-2021), GA18-14259S (2018-2020), GA18-01734S (2018-2020), NV18-09-00181 (2018-2021), GA17-13541S (2017-2019), GA16-13967S (2016-2018), NV15-31847A (2015-2018), GA15-11776S (2015-2017), VVGS-PF-2013-121, VVGS UPJS 43/12-13, VEGA 1/0433/11

 

Membership

  • SK Chemical Society (2009)
  • CZ Chemical Society (2019)

 

International cooperation

  • Institute for Medical Research and Occupational Health, Croatia
  • Jagiellonian University Medical College Krakow, Poland
  • Korea Research Institute of Chemical Technology, Republic of Korea
  • Semmelweis University, Faculty of Pharmacy, Hungary

 

Student supervising and educational activities

Students     Bc. 16 (Head of work) 2 (Consultant)

(finished)    MSc. 4 (Head of work) 5 (Consultant)

                      Ph.D. 1 (Consultant)

Since 2016
Department of Chemistry, Faculty of Science, University of Hradec Kralove
(organic chemistry 1-2, advanced organic chemistry, chemistry of heterocyclic compounds, methods of structural study of organic compounds, mechanisms in organic chemistry, organic and bioorganic chemistry for biologists, laboratory practice from organic chemistry, advanced laboratory practice from organic chemistry, advanced laboratory practice from bioorganic chemistry)

2008–2013
Department of Organic Chemistry, Institute of Chemistry, Faculty of Science UPJŠ in Košice
(mechanisms in organic chemistry, laboratory practice from organic chemistry)

 

Awards

2008 University Rector´s Award for outstanding study results

 

Publication activity

Author od  co-author 39 scientific publications with IF

H-index: 12

Citations without autocitations: 369

Author or co-author of 3 utility models and 1 patent

(dated 02/2021)

 

Selected publications

2021

Handl, Jiri∥; Malinak, David∥; Capek, Jan; Andrys, Rudolf; Rousarova, Erika; Hauschke, Martina; Bruckova, Lenka; Cesla, Petr.; Rousar, Tomas*; Musilek, Kamil*: Effects of Charged Oxime Reactivators on the HK-2 Cell Line in Renal Toxicity Screening. Chemical Research in Toxicology, 2021, in press. IF2019 = 3.184

 

2020

Malinak, David*; Dolezal, Rafael; Hepnarova, Vendula; Hozova, Miroslava; Andrys, Rudolf; Bzonek, Petr; Racakova, 
Veronika; Korabecny, Jan; Gorecki, Lukas; Mezeiova, Eva; Psotka, Miroslav; Jun, Daniel; Kuca, Kamil; Musilek, Kamil*:
Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and
butyrylcholinesterase reactivators. Journal of Enzyme Inhibition and Medicinal Chemistry,2020, vol. 35, no. 1, p. 478-488.
IF2019 = 4.673

 

2019

Salajkova, Sarka; Sramek, Michal; Malinak, David; Havel, Filip; Musilek, Kamil; Benkova, Marketa; Soukup, Ondrej; Vasicova, Pavla; Prchal, Lukas; Dolezal, Rafael; Hodny, Zdenek; Bartek, Jiri; Zarska, Monika*; Kuca, Kamil*: Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity. Journal of Biophotonics,2019, vol. 12, no. UNSP e201900024. IF2019 = 3.032

 

2018

Zorbaz, Tamara∥; Malinak, David∥; Marakovic, Nikola; Macek Hrvat, Nikolina; Zandona, Antonio; Novotny, Michal; 
Skarka, Adam.; Andrys, Rudolf; Benkova, Marketa; Soukup, Ondrej; Katalinic, Maja; Kuca, Kamil; Kovarik, Zrinka*;
Musilek, Kamil*: Pyridinium oximes with ortho-positioned chlorine moiety exhibit improved physicochemical properties
and efficient reactivation of human acetylcholinesterase inhibited by several nerve agents. Journal of Medicinal
Chemistry, 2018, vol.  61, no. 23, p. 10345-10934. IF2018 = 6.054

 

2017

Gorecki, Lukas; Korabecny, Jan; Musilek, Kamil; Nepovimova, Eugenie; Malinak, David; Kucera, Tomas; Dolezal, Rafael; Jun, Daniel; Soukup, Ondrej; Kuca, Kamil*: Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016). Expert opinion on therapeutic patents, 2017, vol. 27, no. 9, p. 971-985. IF2017 = 2.867.

 

2016

Dolezal, Rafael; Soukup, Ondrej; Malinak, David; Savedra, Ranylson M. L.; Marek, Jan; Dolezalova, Marie; Pasdiorova, Marketa; Salajkova, Sarka; Korabecny, Jan; Honegr, Jan; Ramalho, Teodorico C.; Kuca, Kamil*: Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies. European Journal of Medicinal Chemistry, 2016, vol. 121, no. October, p. 699-711. IF2016 = 4.519.

 

2015

Malinak, David; Gonda, Jozef; Korabecny, Jan; Dolezal, Rafael; Honegr, Jan; Soukup, Ondrej; Buzga, Marek; Kuca, Kamil*: A Review of the Total Synthesis of (+)-Lactacystin and its Analogs. Current Organic Chemistry, 2015, vol. 19, no. 20, p. 1980-2001. IF2015 = 1.949.

 

2014

Malinak, David; Dolezal, Rafael; Marek, Jan; Salajkova, Sarka; Soukup, Ondrej; Vejsova, Marcela; Korabecny, Jan; Honegr, Jan; Penhaker, Marek; Musilek, Kamil; Kuca, Kamil*: 6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activity. Bioorganic & Medicinal Chemistry Letters, 2014, vol. 24, no. 22, p. 5238-5241. IF2014 = 2.420.

 

2013

Gonda, Jozef*; Maliňák, Dávid; Kováčová, Margaréta; Martinková, Miroslava; Walko, Martin: A diastereoselective C-C bond formation at C-5 of D-gulose. A convenient approach to (5S)-5-C-alkyl-beta-L-lyxo-hexofuranoses. Tetrahedron Asymmetry, 2013, vol. 24, no. 23, p. 1514-1519. IF2013 = 2.165.

 

 


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    • Benek Ondřej
    • Benková Markéta
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    • Kuča Kamil
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