Postdoctoral fellow
+420 495 832 502
david.malinak@gmail.com
Dávid obtained his PhD in 2013 at the Faculty of Science Pavol Jozef Šafárik University in Košice. The main aim of the thesis was stereocontrolled synthesis of advanced precursor for preparation of (+)-lactacystin. Currently, he is postdoctoral fellow at the Biomedical Research Center (BRC), University Hospital Hradec Kralove, where he dealt with the development of new drugs in the field of adjuvants, nanoparticles, antidotes for organophosphates poisoning, disinfectants and decontamination agents.
| Ph.D. (2013) |
Pavol Jozef Šafárik University in Košice, Faculty of Science Disertation thesis title: Stereocontrolled synthesis of advanced precursor for preparation of (+)-lactacystin |
| RNDr. (2010) |
Pavol Jozef Šafárik University in Košice, Faculty of Science Title of thesis: Total synthesis of (+)-lactacystinwith using of Overman [3,3]-sigmatropic rearrangement |
| Mgr. (2008) |
Pavol Jozef Šafárik University in Košice, Faculty of Science Master thesis title: Heterocumulens of nucleobases as supramolecular building blocks |
| Bc. (2006) |
Pavol Jozef Šafárik University in Košice, Faculty of Science Bachelor thesis title: Chiral separation technics |
Design and synthesis of new molecules as potential adjuvants, nanoparticles, antidotes for organophosphates poisoning, disinfectants and decontamination agents.
| Since 2016 | Assist. Professor in Department of Chemistry, Faculty of Science, University of Hradec Králové |
| Since 2013 | Postdoctoral fellow, Biomedical Research Center, University Hospital Hradec Králové |
| 2012–2013 | Assist. Professor in Insitute of Chemistry, Faculty of Science UPJŠ in Košice |
| 2012–2013 | PhD Study: Faculty of Science UPJŠ in Košice, study: Organic chemistry |
VVGS PF 20/2009/CH, VVGS PF 6/2010/Ch, VVGS 16/2011/Ch – principial investigator of grants
VEGA 1/0433/11, VVGS UPJŠ 43/12-13, VVGS-PF-2013-121 – participated in grants
Students Bc. 8 (head of work) 1 (consultant)
MSc. 1 (head of work) 5 (consultant)
Since 2016 Lecturing at the Department of Chemistry, Faculty of Science, University of Hradec Králové
2008–2013 Lecturing at the Department of Organic Chemistry, Faculty of Science UPJŠ in Košice
2008 Award of rector UPJŠ in Košice for study results
Author od co-author 19 scientific publications with IF
H-index: 7
Citations without autocitations: 112
(dated 06/2018)
Mezeiová, Eva; Špilovská, Katarína; Nepovimová, Eugenie; Górecki, Lukáš; Soukup, Ondřej; Doležal, Rafael; Maliňák, Dávid; Janočková, Jana; Jun, Daniel; Kuča, Kamil; Korábečný, Jan: Profiling donepezil template into multipotent hybrids with antioxidant properties. In: Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, vol. 33, is. 1. p. 583-606. IF 4.293.
Honegr, Jan; Maliňák, Dávid; Doležal, Rafael; Soukup, Ondřej; Benková, Markéta; Hroch, Lukáš; Benek, Ondřej; Janočková, Jana; Kuča, Kamil; Prymula, Roman: Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro. In: European Journal of Medicinal Chemistry, 2018, vol. 146, is. February. p. 38-46. IF 4.519.
Soukup, Ondřej; Korábečný, Jan; Maliňák, Dávid; Nepovimová, Eugenie; Pham, Ngoc L.; Musílek, Kamil; Hrabinová, Martina; Hepnarová, Vendula; Doležal, Rafael; Pávek, Petr; Jošt, Petr; Kobrlová, Tereza; Jankočková, Jana; Górecki, Lukáš; Psotka, Miroslav; Nguyen, Thuy D.; Box, Karl; Outhwaite, Breeze; Ceckova, Martina; Sorf, Ales; Jun, Daniel; Kuča, Kamil: In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley? In: Medicinal Chemistry, 2018, vol. 14, is. 3. p. 281-292. IF 2.331.
Honegr, Jan; Doležal, Rafael; Maliňák, Dávid; Benková, Markéta; Soukup, Ondřej; de Almeida, Joyce S. F. D.; Franca, Tanos C. C.; Kuča, Kamil; Prymula, Roman: Rational Design of a New Class of Toll-Like Receptor 4 (TLR4) Tryptamine Related Agonists by Means of the Structure- and Ligand-Based Virtual Screening for Vaccine Adjuvant Discovery. In: Molecules, 2018, vol. 23, is. 1. p. 1-19. IF 2.861.
Marek, Jan; Maliňák, Dávid; Doležal, Rafael; Soukup, Ondřej; Benková, Markéta; Nachtigal, Petr; Vavral, Petr; Kuča, Kamil: Novel Series of Quaternary Ammonium Surfactants Based on 2,3-Dihydro-[1,4]dioxino[2.3-b]pyridin-7-ol Ring: Synthesis, Analysis and Antimicrobial Evaluation. In: Letters in organic chemistry, 2018, vol. 15, is. 1. p. 3-9. IF 0.730.
Górecki, Lukáš; Korábečný, Jan; Musílek, Kamil; Nepovimová, Eugenie; Maliňák, Dávid; Kučera, Tomáš; Doležal, Rafael; Jun, Daniel; Soukup, Ondřej; Kuča, Kamil: Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016). In: Expert opinion in therapeutic patents, 2017, vol. 27, is. 9. p. 971-985. IF 3.041.
Górecki, Lukáš; Korábečný, Jan; Musílek, Kamil; Maliňák, Dávid; Nepovimová, Eugenie; Doležal, Rafael; Jun, Daniel; Soukup, Ondřej; Kuča, Kamil: SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides. In: Archives of toxicology, 2016, vol. 90, is. 12. p. 2831-2859. IF 5.901.
Doležal, Rafael; Soukup, Ondřej; Maliňák, Dávid; Savedra, Ranylson M. L.; Marek, Jan; Doležalová, Marie; Pasdiorová, Markéta; Salajková, Šárka; Korábečný, Jan; Honegr, Jan; Ramalho, Teodorico C.; Kuča, Kamil: Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies. In: European Journal of Medicinal Chemistry, 2016, vol. 121, is. October p. 699-711. IF 4.519.
Soukup, Ondřej; Doležal, Rafael; Maliňák, Dávid; Marek, Jan; Salajková, Šárka; Pasdiorová, Markéta; Honegr, Jan; Korábečný, Jan; Nachtigal, Petr; Nachon, Florian; Jun, Daniel; Kuča, Kamil: Synthesis, antimicrobial evaluation and molecular modeling of 5-hydroxyisoquinolinium salt series; the effect of the hydroxyl moiety. In: Bioorganic & Medicinal Chemistry, 2016, vol. 24, is. 4. p. 841-848. IF 2.930.
Nepovimová, Eugenie; Korábečný, Jan; Doležal, Rafael; Nguyen, Thuy D.; Jun, Daniel; Soukup, Ondřej; Pasdiorová, Markéta; Jošt, Petr; Mucková, Lubica; Maliňák, Dávid; Górecki, Lukáš; Musílek, Kamil; Kuča, Kamil: A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication. In: Toxicology research, 2016, vol. 5, is. 4. p. 1012-1016. IF 1.969.
Korábečný, Jan; Andrš, Martin; Nepovimová, Eugenie; Doležal, Rafael; Babková, Kateřina; Horová, Anna; Maliňák, Dávid; Mezeiová, Eva; Górecki, Lukáš; Šepsová, Vendula; Hrabinová, Martina; Soukup, Ondřej; Jun, Daniel; Kuča, Kamil: 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment. In: Molecules, 2015, vol. 20, is. 12. p. 22084-22101. IF 2.465.
Nepovimová, Eugenie; Korábečný, Jan; Doležal, Rafael; Babková, Kateřina; Ondrejiček, Aleš; Jun, Daniel; Šepsová, Vendula; Horová, Anna; Hrabinová, Martina; Soukup, Ondřej; Bukum, Neslihan; Jošt, Petr; Mucková, Lubica; Kassa, Jiří; Maliňák, Dávid; Andrš, Martin; Kuča, Kamil: Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity. In: Journal of Medicinal Chemistry, 2015, vol. 58, is. 22. p. 8985-9003. IF 5.589.
Marek, Jan; Maliňák, Dávid; Doležal, Rafael; Soukup, Ondřej; Pasdiorová, Markéta; Doležal, Martin; Kuča, Kamil: Synthesis and Disinfection Effect of the Pyridine-4-aldoxime Based Salts. In: Molecules, 2015, vol. 20, is. 3. p. 3681-3696. IF 2.465.
Doležal, Rafael; Korábečný, Jan; Maliňák, Dávid; Honegr, Jan; Musílek, Kamil; Kuča, Kamil: Ligand-based 3D QSAR analysis of reactivation potency of mono- and bis-pyridinium aldoximes toward VX-inhibited rat acetylcholinesterase. In: Journal of Molecular Graphics and Modeling, 2015, vol. 56, is. March. p. 113-129. IF 1.674.
Honegr, Jan; Soukup, Ondřej; Doležal, Rafael; Maliňák, Dávid; Penhaker, Marek; Prymula, Roman; Kuča, Kamil: Structural Properties of Potential Synthetic Vaccine Adjuvants - TLR Agonists. In: Current Medicinal Chemistry, 2015, vol. 22, is. 29. p. 3306-3325. IF 3.455.
Maliňák, Dávid; Gonda, Jozef; Korábečný, Jan; Doležal, Rafael; Honegr, Jan; Soukup, Ondřej; Bužga, Marek; Kuča, Kamil: A Review of the Total Synthesis of (+)-Lactacystin and its Analogs. In: Current Organic Chemistry, 2015, vol. 19, is. 20. p. 1980-2001. IF 1.949.
Maliňák, Dávid; Doležal, Rafael; Marek, Jan; Salajková, Šárka; Soukup, Ondřej; Vejsová, Marcela; Korábečný, Jan; Honegr, Jan; Penhaker, Marek; Musílek, Kamil; Kuča, Kamil: 6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activity. In: Bioorganic & Medicinal Chemistry Letters, 2014, vol. 24, is. 22. p. 5238-5241. IF 2.420.
Gonda, Jozef; Maliňák, Dávid; Kováčová, Margaréta; Martinková, Miroslava; Walko, Martin: A diastereoselective C-C bond formation at C-5 of D-gulose. A convenient approach to (5S)-5-C-alkyl-beta-L-lyxo-hexofuranoses. In: Tetrahedron Asymmetry, 2013, vol. 24, is. 23. p. 1514-1519. IF 2.165.
Gonda, Jozef; Maliňák, Dávid; Kováčová, Margaréta; Martinková, Miroslava: A convenient approach to an advanced intermediate for (+)-lactacystin synthesis. In: Tetrahedron Letters, 2013, vol. 54, is. 49. p. 6768-6771. IF 2.391.
