Postdoctoral fellow
+420 495 832 502
david.malinak@gmail.com
ORCID: 0000-0002-0665-0667
Researcher ID: AAH-1337-2020
Dávid obtained his PhD in 2013 at the Faculty of Science Pavol Jozef Šafárik University in Košice. The main aim of the thesis was stereocontrolled synthesis of advanced precursor for preparation of (+)-lactacystin. Currently, he is postdoctoral fellow at the Biomedical Research Center (BRC), University Hospital Hradec Kralove, where he dealt with the development of new drugs in the field of adjuvants, nanoparticles, antidotes for organophosphates poisoning, disinfectants and decontamination agents.
| Ph.D. | (2013) |
Pavol Jozef Šafárik University in Košice, Faculty of Science Disertation thesis title: Stereocontrolled synthesis of advanced precursor for preparation of (+)-lactacystin |
| RNDr. | (2010) |
Pavol Jozef Šafárik University in Košice, Faculty of Science Title of thesis: Total synthesis of (+)-lactacystinwith using of Overman [3,3]-sigmatropic rearrangement |
| Mgr. | (2008) |
Pavol Jozef Šafárik University in Košice, Faculty of Science Master thesis title: Heterocumulens of nucleobases as supramolecular building blocks |
| Bc. | (2006) |
Pavol Jozef Šafárik University in Košice, Faculty of Science Bachelor thesis title: Chiral separation technics |
| Since 2016 | Assist. Professor in Department of Chemistry, Faculty of Science, University of Hradec Králové |
| Since 2013 | Postdoctoral fellow, Biomedical Research Center, University Hospital Hradec Králové |
| 2012–2013 | Assist. Professor in Insitute of Chemistry, Faculty of Science UPJŠ in Košice |
| 2012–2013 | PhD Study: Faculty of Science UPJŠ in Košice, study: Organic chemistry |
Principal investigator – GA21-03000S (2021-2023), FNHK 8114 (2017), VVGS PF 16/2011/Ch, VVGS PF 6/2010/Ch, VVGS PF 20/2009/CH
Team member – GA19-11867S (2019-2021), NV18-05-00562 (2018-2021), GA18-14259S (2018-2020), GA18-01734S (2018-2020), NV18-09-00181 (2018-2021), GA17-13541S (2017-2019), GA16-13967S (2016-2018), NV15-31847A (2015-2018), GA15-11776S (2015-2017), VVGS-PF-2013-121, VVGS UPJS 43/12-13, VEGA 1/0433/11
Students Bc. 16 (Head of work) 2 (Consultant)
(finished) MSc. 4 (Head of work) 5 (Consultant)
Ph.D. 1 (Consultant)
Since 2016
Department of Chemistry, Faculty of Science, University of Hradec Kralove
(organic chemistry 1-2, advanced organic chemistry, chemistry of heterocyclic compounds, methods of structural study of organic compounds, mechanisms in organic chemistry, organic and bioorganic chemistry for biologists, laboratory practice from organic chemistry, advanced laboratory practice from organic chemistry, advanced laboratory practice from bioorganic chemistry)
2008–2013
Department of Organic Chemistry, Institute of Chemistry, Faculty of Science UPJŠ in Košice
(mechanisms in organic chemistry, laboratory practice from organic chemistry)
2008 University Rector´s Award for outstanding study results
Author od co-author 39 scientific publications with IF
H-index: 12
Citations without autocitations: 369
Author or co-author of 3 utility models and 1 patent
(dated 02/2021)
2021
Handl, Jiri∥; Malinak, David∥; Capek, Jan; Andrys, Rudolf; Rousarova, Erika; Hauschke, Martina; Bruckova, Lenka; Cesla, Petr.; Rousar, Tomas*; Musilek, Kamil*: Effects of Charged Oxime Reactivators on the HK-2 Cell Line in Renal Toxicity Screening. Chemical Research in Toxicology, 2021, in press. IF2019 = 3.184
2020
Malinak, David*; Dolezal, Rafael; Hepnarova, Vendula; Hozova, Miroslava; Andrys, Rudolf; Bzonek, Petr; Racakova,
Veronika; Korabecny, Jan; Gorecki, Lukas; Mezeiova, Eva; Psotka, Miroslav; Jun, Daniel; Kuca, Kamil; Musilek, Kamil*:
Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and
butyrylcholinesterase reactivators. Journal of Enzyme Inhibition and Medicinal Chemistry,2020, vol. 35, no. 1, p. 478-488.
IF2019 = 4.673
2019
Salajkova, Sarka; Sramek, Michal; Malinak, David; Havel, Filip; Musilek, Kamil; Benkova, Marketa; Soukup, Ondrej; Vasicova, Pavla; Prchal, Lukas; Dolezal, Rafael; Hodny, Zdenek; Bartek, Jiri; Zarska, Monika*; Kuca, Kamil*: Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity. Journal of Biophotonics,2019, vol. 12, no. UNSP e201900024. IF2019 = 3.032
2018
Zorbaz, Tamara∥; Malinak, David∥; Marakovic, Nikola; Macek Hrvat, Nikolina; Zandona, Antonio; Novotny, Michal;
Skarka, Adam.; Andrys, Rudolf; Benkova, Marketa; Soukup, Ondrej; Katalinic, Maja; Kuca, Kamil; Kovarik, Zrinka*;
Musilek, Kamil*: Pyridinium oximes with ortho-positioned chlorine moiety exhibit improved physicochemical properties
and efficient reactivation of human acetylcholinesterase inhibited by several nerve agents. Journal of Medicinal
Chemistry, 2018, vol. 61, no. 23, p. 10345-10934. IF2018 = 6.054
2017
Gorecki, Lukas; Korabecny, Jan; Musilek, Kamil; Nepovimova, Eugenie; Malinak, David; Kucera, Tomas; Dolezal, Rafael; Jun, Daniel; Soukup, Ondrej; Kuca, Kamil*: Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016). Expert opinion on therapeutic patents, 2017, vol. 27, no. 9, p. 971-985. IF2017 = 2.867.
2016
Dolezal, Rafael; Soukup, Ondrej; Malinak, David; Savedra, Ranylson M. L.; Marek, Jan; Dolezalova, Marie; Pasdiorova, Marketa; Salajkova, Sarka; Korabecny, Jan; Honegr, Jan; Ramalho, Teodorico C.; Kuca, Kamil*: Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies. European Journal of Medicinal Chemistry, 2016, vol. 121, no. October, p. 699-711. IF2016 = 4.519.
2015
Malinak, David; Gonda, Jozef; Korabecny, Jan; Dolezal, Rafael; Honegr, Jan; Soukup, Ondrej; Buzga, Marek; Kuca, Kamil*: A Review of the Total Synthesis of (+)-Lactacystin and its Analogs. Current Organic Chemistry, 2015, vol. 19, no. 20, p. 1980-2001. IF2015 = 1.949.
2014
Malinak, David; Dolezal, Rafael; Marek, Jan; Salajkova, Sarka; Soukup, Ondrej; Vejsova, Marcela; Korabecny, Jan; Honegr, Jan; Penhaker, Marek; Musilek, Kamil; Kuca, Kamil*: 6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activity. Bioorganic & Medicinal Chemistry Letters, 2014, vol. 24, no. 22, p. 5238-5241. IF2014 = 2.420.
2013
Gonda, Jozef*; Maliňák, Dávid; Kováčová, Margaréta; Martinková, Miroslava; Walko, Martin: A diastereoselective C-C bond formation at C-5 of D-gulose. A convenient approach to (5S)-5-C-alkyl-beta-L-lyxo-hexofuranoses. Tetrahedron Asymmetry, 2013, vol. 24, no. 23, p. 1514-1519. IF2013 = 2.165.
