Postdoctoral fellow
+420 495 833 411
martin.novak@fnhk.cz
ORCID: 0000-0001-9692-7641
Martin obtained his Master degree in 2018 in the study program Medicinal Bioanalytics at the Faculty of Pharmacy in Hradec Kralove, Charles University. The main aim of his master thesis was optimization of chiral separation of acetylcholinesterase tacrine inhibitors by HPLC. In 2023, he successfully completed his PhD studies at the Department of Pharmaceutical Chemistry and Pharmaceutical Analysis at the Faculty of Pharmacy, Charles University, where he studied the use of HPLC-MS in the study of substances that can be used in the therapy of Alzheimer's disease. Currently, Martin works at Biomedical research centre (BRC) in University Hospital in Hradec Kralove at the position of analytical chemist and also is an teacher at the Department of Pharmaceutical Chemistry and Pharmaceutical Analysis at the Faculty of Pharmacy. In his scientific activity, he continues to deal with the development of potential drugs for Alzheimer's disease and the development of antituberculotics drugs.
| 2024 | RNDr. |
Charles University in Prague, Faculty of Pharmacy Hradec Králové |
| 2023 | PhD. |
Study program: Pharmaceutical analysis, Charles University – Faculty of Pharmacy in Hradec Kralove, Dissertation thesis file: Use of HPLC-HRMS for the study of tacrine group compounds potentially useful in the therapy of Alzheimer's disease. |
| 2018 | MSc. |
Charles University – Faculty of Pharmacy in Hradec Kralove, Study program Medicinal bianalytics, Master thesis title: Optimization of chromatographic parameters for chiral separation of biologically active compounds. |
| Since 2023 | Teaching activities, Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy, Charles University |
| Since 2018 | Researcher - Biomedical Research Centre in University Hospital in Hradec Kralove |
| 2015–2018 | Healthcare Laboratory Assistant in research - Biomedical Research Centre in University Hospital in Hradec Kralove |
| 02–04/2023 | University of Tübingen (Germany) |
| 06–08/2018 | University of Las Palmas de Gran Canaria (Spain) |
Novak M., Vajrychova M., Koutsilieri S., Sismanoglou D., Kobrlova T., Prchal L., Svobodova B., Korabecny J., Zarybnicky T., Raisova-Stuchlikova L., Skalova L., Lauschke V. M., Kucera R., Soukup O. Tacrine first phase biotransformation and associated hepatotoxicity; a possible way to avoid quinone methide formation. ACS Chem. Biol (2023); 19 (9), 1993-2002.
Finger V., Kucera T., Kafkova R., Muckova L., Dolezal R., Kubes J., Novak M., Prchal L., Lakatos L. Andrs M., Hympanova M., Kufa M., Spiwok V., Soukup O., Mezeiova E., Janousek J. Nevosadova L., Benkova M., Kitson R., Kratky, M., Bösze S., Mikušová k., Hartkoorn R., Roh J., Korabecny J. 2,6-Disubstituted 7-(Naphthalen-2-Ylmethyl)-7h-Purines as a New Class of Potent Antitubercular Agents Inhibiting Dpre1. Eur J Med Chem (2023); 258, 115611.
Nawroth D., Bouz G., Jandourek O., Konecna K., Paterova P., Barta P., Novak M., Kučera R., Zemanova J., Forbak M., Kordulakova J., Pavlis O., Kubickova P., Dolezal M., Zitko M. Antimycobacterial pyridine carboxamides: from design to in vivo activity. Eur J Med Chem (2023); 258; 115617.
Novak M., Svobodova B., Konecny J., Kuratkova A., Nevosadova L., Prchal L., Korabecny J., Lauschke V. M., Soukup O., Kucera R. UHPLC-Orbitrap study of the first phase tacrine in vitro metabolites and related Alzheimer’s drug candidates using human liver microsomes. J Pharm Biomed Anal (2023); 224; 115154.
Gorecki L., Misiachna A., Damborsky J., Dolezal R., Korabecny J., Cejkova L., Hakenova K., Chvojkova M., Karasova Zdarova J., Prchal L., Novak M., Kolcheva M., Kortus S., Vales M., Horak M., Soukup O. Structure-activity realtionships of dually-acting acetylcholiesterase inhibitors derived from tacrine on N-methyl-D-Aspartate receptors. Eur J Med Chem (2021); 219; 113434.
Kaniakova M., Korabecny J., Holubova K., Kleteckova L., Chvojkova M., Hakenova K., Prchal L., Novak M., Dolezal R., Hepnarova V., Svobodova B., Kucera T., Lichnerova K., Krausova B., Horak M., Vales K., Soukup O. 7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo. Biochem Pharmacol (2021); 186; 114460.
Montesdeoca-Esponda S., Torres-Pardon M. E., Novak M., Krchova L., Sosa Ferrera Z., Rodriguer Santana J. J. Occurrence of Benzotriazole UV Stabilizers in Coastal Fishes. J Environ Manage (2020); 269; 110805.
Godyn, J., Gucwa D., Kobrlova T., Novak M., Soukup O., Malawska B., Bajda M. Novel Application of Capillary Electrophoresis with a Liposome Coated Capillary for Prediction of Blood-Brain Barrier Permeability. Talanta (2020); 217; 121023.
