Benek Ondřej | Centrum biomedicínského výzkumu

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Benek Ondřej

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Postdoctoral fellow
+420 495 833 195
ondrej.benek@fnhk.cz
ORCID: 0000-0001-6840-1933


Ondrej obtained his MSc in 2011 at the Faculty of Pharmacy, Charles University. The main aim of his diploma thesis was to synthesize quaternary compounds as potential inhibitors of acetylcholinesterase. In 2016 he successfully finished his postgraduate studies at the Faculty of Military Health Sciences, University of Defence and obtained the doctoral degree from Toxicology. Within the topic of his dissertation thesis he concerned himself with design, synthesis and evaluation of modulators of mitochondrial enzymes as potential therapeutics of Alzheimer's disease.

He is currently working as postdoc/ academic fellow at the Faculty of Science, University of Hradec Kralove and as a researcher at the Biomedical Research Center, University Hospital in Hradec Kralove and National Institute of Mental Health, Klecany.

Education

PharmDr. (2017) Medicinal chemistry, Faculty of Pharmacy, Charles University
Ph.D. (2016)

Toxicology, Faculty of Military Health Sciences, University of Defence
Dissertation thesis title: Preparation and evaluation of potential drugs inhibiting mitochondrial enzymes

Mgr.        (2011)

Pharmacy, Faculty of Pharmacy, Charles University
Master thesis title: Preparation and in vitro screening of quaternary inhibitors of acetylcholinesterase

 

Research Focus

Design, synthesis and evaluation of novel therapeutics

Alzheimer's disease

 

Professional Training

Since 2016 postdoc/academic fellow, University of Hradec Kralove, Faculty of Science, CZ
Since 2015 researcher, National Institute of Mental Health, CZ
Since 2012 researcher, University Hospital in Hradec Kralove, Biomedical Research Center, CZ

 

International Experience

2017

Faculty of Pharmacy, University of Ljubljana, Slovenia (3 months)

2014 Institute of General Organic Chemistry, CSIC, Madrid, Spain (2 months)
2013 Biomedical Sciences Research Centre, University of St Andrews, UK (1 month)

 

Projects

Title: Výzkum oxim-CB(7) komplexů při prostupu kvarterních reaktivátorů acetylcholinestarasy do centrálního nervového systému 
Funding:

Grantová agentura ČR (18-08937S)

Schedule: 2018–2020
Role: member of a team
Title:

Reaktivátor acetylcholinesterasy s potenciálně aktivním transportem přes hematoencefalickou bariéru

Funding:

Interní grantová soutěž FN HK

Schedule: 2018
Role: principal investigator
Title Modulátory mitochondriálních enzymů k léčbě neurodegenerativních onemocnění
Funding: Agentura pro zdravotnický výzkum ČR (NV15-28967A)
Schedule: 2015–2018
Role: Member of a team
Title Příprava a testování léčiv s potenciálním profylaktickým efektem proti nervově paralytickým látkám a Alzheimerově nemoci
Funding: Ministerstvo školství, mládeže a tělovýchovy (No. SV/FVZ201201)
Schedule: 2012–2014
Role: member of a team


Cooperation

Since 2011 Medical and Biological Sciences Building, School of Biology, University of St. Andrews, Scotland

 

Student supervising and education activities

Since 2016

Teaching of subjects Toxicology of inorganic and organic compounds; General and inorganic chemistry; Laboratory practice in bioorganic chemistry at Faculty of Science UHK


Publication activity

Author or co-author of 10 scientific publications with IF

H-index: 4

Citations without autocitations: 36

(dated 6/2018)


Selected Publications

Benek, O.; Hroch, L.; Aitken, L.; Gunn-Moore, F.; Vinklarova, L.; Kuca, K.; Perez, D. I.; Perez, C.; Martinez, A.; Fisar, Z.; Musilek, K. 1-(Benzo[d]thiazol-2-yl)-3-Phenylureas as Dual Inhibitors of Casein Kinase 1 and ABAD Enzymes for Treatment of Neurodegenerative Disorders. J. Enzyme Inhib. Med. Chem. 2018, 33 (1), 665–670. DOI:    10.1080/14756366.2018.1445736. IF = 4.293

Honegr, J.; Malinak, D.; Dolezal, R.; Soukup, O.; Benkova, M.; Hroch, L.; Benek, O.; Janockova, J.; Kuca, K.; Prymula, R. Rational Design of Novel TLR4 Ligands by in Silico Screening and Their Functional and Structural Characterization in Vitro. Eur. J. Med. Chem. 2018, 146, 38–46. DOI: 10.1016/j.ejmech.2017.12.074. IF = 4.519

Benek, O.; Hroch, L.; Aitken, L.; Dolezal, R.; Hughes, R.; Guest, P.; Benkova, M.; Soukup, O.; Musil, K.; Kuca, K.; Smith, T. K.; Gunn-Moore, F.; Musilek, K. 6-Benzothiazolyl Ureas, Thioureas and Guanidines Are Potent Inhibitors of ABAD/17 Beta-HSD10 and Potential Drugs for Alzheimer’s Disease Treatment: Design, Synthesis and in Vitro Evaluation. Med. Chem. 2017, 13 (4), 345–358, DOI: 10.2174/1573406413666170109142725. IF = 2.331

Hroch, L.; Guest, P.; Benek, O.; Soukup, O.; Janockova, J.; Dolezal, R.; Kuca, K.; Aitken, L.; Smith, T. K.; Gunn-Moore, F.; Zala, D.; Ramsay, R. R.; Musilek, K. Synthesis and Evaluation of Frentizole-Based Indolyl Thiourea Analogues as MAO/ABAD Inhibitors for Alzheimer’s Disease Treatment. Bioorg. Med. Chem. 2017, 25 (3), 1143–1152, DOI: 10.1016/j.bmc.2016.12.029. IF = 2.930

Hroch, L.; Benek, O.; Guest, P.; Aitken, L.; Soukup, O.; Janockova, J.; Musil, K.; Dohnal, V.; Dolezal, R.; Kuca, K.; Smith, T. K.; Gunn-Moore, F.; Musilek, K. Design, Synthesis and in Vitro Evaluation of Benzothiazole-Based Ureas as Potential ABAD/17β-HSD10 Modulators for Alzheimer’s Disease Treatment. Bioorg. Med. Chem. Lett. 2016, 26, 3675–3678, DOI: 10.1016/j.bmcl.2016.05.087. IF = 2.420

Andrs, M.; Muthna, D.; Rezacova, M.; Seifrtova, M.; Siman, P.; Korabecny, J.; Benek, O.; Dolezal, R.; Soukup, O.; Jun, D.; Kuca, K. Novel Caffeine Derivatives with Antiproliferative Activity. RSC Adv. 2016, 6 (39), 32534–32539, DOI:10.1039/C5RA22889A. IF = 3.84

Benek, O.; Soukup, O.; Pasdiorova, M.; Hroch, L.; Sepsova, V.; Jost, P.; Hrabinova, M.; Jun, D.; Kuca, K.; Zala, D.; Ramsay, R. R.; Marco-Contelles, J.; Musilek, K. Design, Synthesis and in Vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease. ChemMedChem. 2016, 11, 1264–1269, DOI: 10.1002/cmdc.201500383. IF = 2.968

Benek, O.; Aitken, L.; Hroch, L.; Kuca, K.; Gunn-Moore, F.; Musilek, K. A Direct Interaction between Mitochondrial Proteins and Amyloid-Β Peptide and Its Significance for the Progression and Treatment of Alzheimer’s Disease. Curr. Med. Chem. 2015, 22, 1056–1085, DOI: 10.2174/0929867322666150114163051. IF = 3.853

Hroch, L.; Aitken, L.; Benek, O.; Dolezal, M.; Kuca, K.; Gunn-Moore, F.; Musilek, K. Benzothiazoles - Scaffold of Interest for CNS Targeted Drugs. Curr. Med. Chem. 2015, 22, 730–747, DOI: 10.2174/0929867322666141212120631. IF = 3.853

Benek, O.; Musilek, K.; Horova, A.; Dohnal, V.; Dolezal, R.; Kuca, K. Preparation, In Vitro Screening and Molecular Modelling of Monoquaternary Compounds Related to the Selective Acetylcholinesterase Inhibitor BW284c51. Med. Chem. 2014, 11, 21–29, DOI: 10.2174/1573406410666140428153110. IF = 1.387

 

 


  • Introduction
  • Our team
    • Team members
    • Andrš Martin
    • Benek Ondřej
    • Benková Markéta
    • Doležal Rafael
    • Fabrik Ivo
    • Fabriková Daniela
    • Finger Vladimír
    • Górecki Lukáš
    • Hatlapatková Jana
    • Hrabinová Martina
    • Hympánová Michaela
    • Janoušek Jiří
    • Kobrlová Tereza
    • Konečný Jan
    • Korábečný Jan
    • Kuča Kamil
    • Kupčík Rudolf
    • Lenčo Juraj
    • Maliňák Dávid
    • Marek Jan
    • Marková Aneta
    • Mezeiová Eva
    • Múčková Ľubica
    • Musílek Kamil
    • Novák Martin
    • Prchal Lukáš
    • Psotka Miroslav
    • Pulkrábková Lenka
    • Schmidt Monika
    • Soukup Ondřej
    • Svobodová Barbora
    • Tichý Aleš
    • Vajrychová Marie
    • Vaňousová Andrea
    • Živná Natálie
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