Postdoctoral fellow
+420 495 833 411
lukas.prchal@fnhk.cz
ORCID: 0000-0001-9698-4478
Lukas received his Ph.D. title in 2017 at the Department of Biochemical Sciences of Faculty of Pharmacy in Hradec Králové, Charles University. His thesis focused on metabolism of xenobiotics in parasitic helminths, specifically on metabolism of anthelmintics in helminths and their hosts using high performance liquid chromatography and mass spectrometry. Since 2018 he has been working at a postdoc position at the Biomedical Research Center, University Hospital Hradec Králové as an analytical researcher in a drug development.
| Ph.D. | (2017) |
Charles University, Faculty of Pharmacy in Hradec Králové, Department of Biochemical Sciences, Ph.D. programme: Patobiochemistry and Xenobiochemistry |
| MSc.. | (2012) |
Charles University, Faculty of Pharmacy in Hradec Králové, Master’s programme: Pharmacy |
Sample preparation and HPLC-MS analysis of small molecules, metabolism and kinetics of drugs
| Since 2018 | Postdoc at the Biomedical Research Center, University Hospital Hradec Králové |
| 2014 | Certificate for appropriete handling of laboratory animals |
| 2012–2016 | Ph.D. student at the Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University |
| 1/2015–7/2015 |
6 months research internship at IBERS (The Institute of Biological, Environmental and Rural Sciences), Aberystwyth University, Aberystwyth, Wales, UK (Proffesor Peter Brophy) |
| Title: |
Development and introduction of HPLC-MS method to detect metabolites of anthelmintics |
| Funding: |
Internal project of Charles University 2015 No. 160/47/55707 |
| Schedule: | 2015 |
| Role: | principal investigator |
Author or co-author of 7 scientific publications in journals with IF
H-index: 4
Citations without self-citations: 30
(dated 5/2018)
Prchal, L., Vokřál, I., Kašný, M., Rejšková, L., Zajíčková, M., Lamka, J., Skálová, L., Lecová, L. and Szotáková, B. (2016b). Metabolism of drugs and other xenobiotics in giant liver fluke ( Fascioloides magna ). Xenobiotica 46, 132–140. doi:10.3109/00498254.2015.1060370.
Prchal, L., Podlipná, R., Lamka, J., Dědková, T., Skálová, L., Vokřál, I., Lecová, L., Vaněk, T. and Szotáková, B. (2016). Albendazole in environment: faecal concentrations in lambs and impact on lower development stages of helminths and seed germination. Environmental science and pollution research international 23, 13015–22. doi:10.1007/s11356-016-6472-0.
Prchal, L., Bártíková, H., Bečanová, A., Jirásko, R., Vokřál, I., Stuchlíková, L., Skálová, L., Kubíček, V., Lamka, J., Trejtnar, F. and Szotáková, B.: Biotransformation of anthelmintics and the activity of drug-metabolizing enzymes in the tapeworm Moniezia expansa. Parasitology, 2014, e-pub p. 1–12. doi:10.1017/S0031182014001711.
Lecová L., Stuchlíková L., Prchal L., Skálová L.: Monepantel - the most studied new anthelmintic drug of recent years. Parasitology, 2014 vol. 141, p. 1686-98.
Vokřál I., Bártíková H., Prchal L., Stuchlíková L., Skálová L, Szotáková B., Lamka L., Várady M. and Kubíček V.: The metabolism of flubendazole and the activities of selected biotransformation enzymes in Haemonchus contortus strains susceptible and resistant to anthelmintics. Parasitology, 2012, vol. 139, p. 1309-1316.
