Prchal Lukáš | Centrum biomedicínského výzkumu

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Prchal Lukáš

Info

For Czech version click here

 

Postdoctoral fellow
+420 495 833 411
lukas.prchal@fnhk.cz
ORCID: 0000-0001-9698-4478


Lukas received his Ph.D. title in 2017 at the Department of Biochemical Sciences of Faculty of Pharmacy in Hradec Králové, Charles University. His thesis focused on metabolism of xenobiotics in parasitic helminths, specifically on metabolism of anthelmintics in helminths and their hosts using high performance liquid chromatography and mass spectrometry. Since 2018 he has been working at a postdoc position at the Biomedical Research Center, University Hospital Hradec Králové as an analytical researcher in a drug development.

 

Education

Ph.D. (2017)

Charles University, Faculty of Pharmacy in Hradec Králové, Department of Biochemical Sciences, Ph.D. programme: Patobiochemistry and Xenobiochemistry
Thesis subject: Anthelmintic and other xenobiotic biotransformation in helminths and its contribution to resistance development

MSc.. (2012)

Charles University, Faculty of Pharmacy in Hradec Králové, Master’s programme: Pharmacy
Diploma thesis: Transport and biotransformation of anthelmintics in susceptible and resistant strains of Barber’s pole worm (Haemonchus contortus)

 

Research Focus

Sample preparation and HPLC-MS analysis of small molecules, metabolism and kinetics of drugs 

 

Profesional Training

Since 2018 Postdoc at the Biomedical Research Center, University Hospital Hradec Králové
2014 Certificate for appropriete handling of laboratory animals 
2012–2016 Ph.D. student at the Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University 

 

Foreign Experience

1/2015–7/2015

6 months research internship at IBERS (The Institute of Biological, Environmental and Rural Sciences), Aberystwyth University, Aberystwyth, Wales, UK (Proffesor Peter Brophy)

 

Projects

Title:

Development and introduction of HPLC-MS method to detect metabolites of anthelmintics 

Funding:

Internal project of Charles University 2015 No. 160/47/55707

Schedule: 2015
Role:  principal investigator

 

Publication activity

Author or co-author of 7 scientific publications in journals with IF

H-index: 4

Citations without self-citations: 30

(dated 5/2018)

 

Selected publications

2016

Prchal, L., Vokřál, I., Kašný, M., Rejšková, L., Zajíčková, M., Lamka, J., Skálová, L., Lecová, L. and Szotáková, B. (2016b). Metabolism of drugs and other xenobiotics in giant liver fluke ( Fascioloides magna ). Xenobiotica 46, 132–140. doi:10.3109/00498254.2015.1060370.

Prchal, L., Podlipná, R., Lamka, J., Dědková, T., Skálová, L., Vokřál, I., Lecová, L., Vaněk, T. and Szotáková, B. (2016). Albendazole in environment: faecal concentrations in lambs and impact on lower development stages of helminths and seed germination. Environmental science and pollution research international 23, 13015–22. doi:10.1007/s11356-016-6472-0.

 

2014

Prchal, L., Bártíková, H., Bečanová, A., Jirásko, R., Vokřál, I., Stuchlíková, L., Skálová, L., Kubíček, V., Lamka, J., Trejtnar, F. and Szotáková, B.: Biotransformation of anthelmintics and the activity of drug-metabolizing enzymes in the tapeworm Moniezia expansa. Parasitology, 2014, e-pub p. 1–12. doi:10.1017/S0031182014001711.

Lecová L., Stuchlíková L., Prchal L., Skálová L.: Monepantel - the most studied new anthelmintic drug of recent years. Parasitology, 2014 vol. 141, p. 1686-98.

 

2012

Vokřál I., Bártíková H., Prchal L., Stuchlíková L., Skálová L, Szotáková B., Lamka L., Várady M. and Kubíček V.: The metabolism of flubendazole and the activities of selected biotransformation enzymes in Haemonchus contortus strains susceptible and resistant to anthelmintics. Parasitology, 2012, vol. 139, p. 1309-1316.


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