Senior researcher
+420 495 832 502
Rafael.Dolezal@fnhk.cz
ORCID: 0000-0001-9495-3934
Rafael received his Ph.D. at the Faculty of Pharmacy (Charles University) in Hradec Kralove in 2008. The dissertation thesis was focused on exploring the quantitative structure-activity relationships (QSAR) of potential drugs against tuberculosis with the use of quantum chemistry computational methods. At present, as a senior researcher at the Biomedical Research Center (BRC) of University Hospital Hradec Kralove, he deals with the development and testing of new therapeutics against Alzheimer's disease.
| Assoc. Prof. | (2020) | Charles University in Prague, Faculty of Pharmacy, Czech Republic, field of expertise: Medicinal Chemistry |
| ---. | (2019) | University of Hradec Kralove, Faculty of Informatics and Management, postgraduate study in the field Applied Informatics (2014-2019) |
| MSc. | (2012) | Charles University in Prague, Catholic Theological Faculty, Czech Republic, field of study: Catholic Theology |
| Master thesis title: „Theological view of healing in Christianity and selected spiritual streams of the 20th century” | ||
| Ph.D. | (2008) | Charles University in Prague, Faculty of Pharmacy, Department of Inorganic and Organic Chemistry, field of study: Bioorganic Chemistry |
| Dissertation thesis title: “Quantitative structure-antimycobacterial acitivity relationships in the group of potential antituberculotics” | ||
| MSc. | (2004) | University of Hradec Králové, Faculty of Education, field of study: Teaching CH-FT |
| Master thesis title: „Computer modeling of reactivity of organic compounds” |
Molecular structure design and optimization of pharmacological properties of potential drugs
| Since 2012 | Senior researcher, Biomedical Research Center (BRC), University Hospital Hradec Kralove |
| 2004 - 2008 | Ph.D. student, Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague |
| 2-6/2006 | Ghent University (Belgium), Department of Inorganic and Physical chemistry (5 months) |
| Title: | Application of molecular modeling to research of the relationships between structure and biological activity of organic compounds |
| Funding: | Higher Education Development Fund, FRVŠ no. 946/2006 |
| Schedule: | 2006 |
| Role: | chief researcher |
| 2006 - 2007 | Teaching of Organic chemistry and Biological activity seminars |
(dated 11/2013)
Sepsova, V., Karasova, J. Z., Korabecny, J., Dolezal, R., Zemek, F., Bennion, B. J., Kuca, K.: Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study. Int. J. Mol. Sci. 2013, 14(8), 16882-16900.
Korabecny, J., Janovec, L., Musilek, K., Zemek, F., Horova, A., Nepovimova, E., Dolezal, R., Opletalova, V., Hroudova, J., Fisar, Z., Jung, Y. S., Kuca, K.: Comparison of Novel Tacrine and 7-MEOTA Derivatives with Aromatic and Alicyclic Residues: Synthesis, Biological Evaluation and Docking Studies. Lett. Org. Chem. 2013, 10(4), 291-297.
Petrlíková, E., Waisser K., Doležal, R., Holý, P., Gregor, J., Kuneš, J., Kaustová J.: Antimycobacterial 3-phenyl-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and 3-phenyl-2H-1,3-benzoxazine-2,4(3H)-dithiones substituted on phenyl and benzoxazine moiety in position 6. Chem. Pap. 2011, 65 (3), 352-366.
Nesměrák K., Doležal R., Hudská V., Bártl J., Štícha M., Waisser K.: Quantitative Structure–Electrochemistry Relationship of 1-Phenyl-5-benzyl-sulfanyltetrazoles and Their Electrooxidation as a Metabolic Model. Electroanalysis 2010, 22(17-18), 2117–2122.
Doležal, R., Waisser, K., Petrlíková, E., Kuneš, J., Kubicová, L., Macháček, M., Kaustová, J.,Dahse H. M.: N-Benzylsalicylthioamides: Highly Active Potential Antituberculotics. Arch. Pharm. Life Sci. 2009, 342, 113-119.
Doležal, R., Van Damme, S., Bultinck, P., Waisser, K.: QSAR analysis of salicylamide isosteres with the use of quantum chemical molecular descriptors. Eur. J. Med. Chem. 2009, 44(2), 869-876.
Waisser K., Matyk J., Kuneš J., Doležal R., Kaustová J., Dahse H. M.: Highly aktive potential antituberculotics: 3-(4-alkyl)phenyl-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and 3-(4-alkylphenyl)-2H-1,3-benzoxazine-2,4(3H)-dithiones substituted in ring B by halogen. Arch. Pharm. Life Sci. 2008, 341, 800-803.
