Doležal Rafael | Centrum biomedicínského výzkumu

Telephone switchboard
+420 495 831 111

Služba přepisu telefonických hovorů pro sluchově postižené cze
  • Hospital
    • COVID19 information
    • University Hospital Hradec Králové
    • Departments
    • Management
    • History
    • Numbers
    • Faculty of Medicine in Hradec Králové
  • Emergency
    • Emergency Service
    • Emergency Service for Adults
    • Emergency Service for Children
    • Emergency Dental Care
    • Emergency Pharmacy
  • Research
    • Research and Science
    • Centre for Transfer of Biomedical Technologies
    • Biomedical Research Center
  • Photos
    • Present
    • History
    • Projects
  • Contact
    • Address
    • Map
    • Bank Accounts

Doležal Rafael

Info RD aj

For Czech version click here

 

Postdoctoral fellow
+420 495 832 502
Rafael.Dolezal@fnhk.cz
ORCID: 0000-0001-9495-3934


Rafael received his Ph.D. at the Faculty of Pharmacy (Charles University) in Hradec Kralove in 2008. The dissertation thesis was focused on researching the quantitative structure-activity relationships (QSAR) of potential drugs against tuberculosis with the use of quantum chemistry computational methods. At present, as a postdoctoral fellow at the Biomedical Research Center (BRC) of University Hospital Hradec Kralove, he deals with the development and testing of new therapeutics against Alzheimer's disease.


Education

MSc. (2012) Charles University in Prague, Catholic Theological Faculty, Czech Republic
    Master thesis title: „A theological view of healing in Christianity and selected spiritual streams of the 20th century”
Ph.D. (2008) Charles University in Prague, Faculty of Pharmacy, Department of Inorganic and Organic Chemistry
    Dissertation thesis title: “Quantitative structure-antimycobacterial acitivity relationships in the group of potential antituberculotics”
MSc. (2004) University of Hradec Králové, Faculty of Education
    Master thesis title: „Computer modeling of reactivity of organic compounds”


Research Focus

Molecular structure design and optimization of pharmacological properties of potential drugs


Professional Training

Since 2012 Postdoctoral fellow, Biomedical Research Center (BRC), University Hospital Hradec Kralove
2004 - 2008 Ph.D. student, Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague


International Experience

2-6/2006 Ghent University (Belgium), Department of Inorganic and Physical chemistry (5 months)


Projects

Title: Application of molecular modeling to research of the relationships between structure and biological activity of organic compounds
Funding: Higher Education Development Fund, FRVŠ no. 946/2006
Schedule: 2006
Role: chief researcher


Educational activity

2006 - 2007 Teaching of Organic chemistry and Biological activity seminars


Publication activity

  • Author or co-author 9 scinetific publications with IF
  • Co-autor of a textbook: Kolář K., Myška K., Doležal R., Marek J.: Computer models in teaching chemistry. Hradec Králové: Gaudeamus, 2006.
  • H-index: 5
  • Number of citations without self-citations: 59

(dated 11/2013)


Selected publications

2013

Sepsova, V., Karasova, J. Z., Korabecny, J., Dolezal, R., Zemek, F., Bennion, B. J., Kuca, K.: Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study. Int. J. Mol. Sci. 2013, 14(8), 16882-16900.

Korabecny, J., Janovec, L., Musilek, K., Zemek, F., Horova, A., Nepovimova, E., Dolezal, R., Opletalova, V., Hroudova, J., Fisar, Z., Jung, Y. S., Kuca, K.: Comparison of Novel Tacrine and 7-MEOTA Derivatives with Aromatic and Alicyclic Residues: Synthesis, Biological Evaluation and Docking Studies. Lett. Org. Chem. 2013, 10(4), 291-297.

2011

Petrlíková, E., Waisser K., Doležal, R., Holý, P., Gregor, J., Kuneš, J., Kaustová J.: Antimycobacterial 3-phenyl-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and 3-phenyl-2H-1,3-benzoxazine-2,4(3H)-dithiones substituted on phenyl and benzoxazine moiety in position 6. Chem. Pap. 2011, 65 (3), 352-366.

2010

Nesměrák K., Doležal R., Hudská V., Bártl J., Štícha M., Waisser K.: Quantitative Structure–Electrochemistry Relationship of 1-Phenyl-5-benzyl-sulfanyltetrazoles and Their Electrooxidation as a Metabolic Model. Electroanalysis 2010, 22(17-18), 2117–2122.

2009

Doležal, R., Waisser, K., Petrlíková, E., Kuneš, J., Kubicová, L., Macháček, M., Kaustová, J.,Dahse H. M.: N-Benzylsalicylthioamides: Highly Active Potential Antituberculotics. Arch. Pharm. Life Sci. 2009, 342, 113-119.

Doležal, R., Van Damme, S., Bultinck, P., Waisser, K.: QSAR analysis of salicylamide isosteres with the use of quantum chemical molecular descriptors. Eur. J. Med. Chem. 2009, 44(2), 869-876.

2008

Waisser K., Matyk J., Kuneš J., Doležal R., Kaustová J., Dahse H. M.: Highly aktive potential antituberculotics: 3-(4-alkyl)phenyl-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and 3-(4-alkylphenyl)-2H-1,3-benzoxazine-2,4(3H)-dithiones substituted in ring B by halogen. Arch. Pharm. Life Sci. 2008, 341, 800-803.


  • Introduction
  • Our team
    • Team members
    • Andrš Martin
    • Benek Ondřej
    • Benková Markéta
    • Bílková Zuzana
    • Doležal Rafael
    • Fabrik Ivo
    • Fabriková Daniela
    • Finger Vladimír
    • Górecki Lukáš
    • Hatlapatková Jana
    • Hrabinová Martina
    • Hympánová Michaela
    • Chalupová Katarína
    • Janoušek Jiří
    • Junová Lucie
    • Kobrlová Tereza
    • Konečný Jan
    • Korábečný Jan
    • Kuča Kamil
    • Kupčík Rudolf
    • Lenčo Juraj
    • Maliňák Dávid
    • Marek Jan
    • Marková Aneta
    • Mezeiová Eva
    • Múčková Ľubica
    • Musílek Kamil
    • Novák Martin
    • Prchal Lukáš
    • Psotka Miroslav
    • Pulkrábková Lenka
    • Schmidt Monika
    • Soukup Ondřej
    • Svobodová Barbora
    • Tichý Aleš
    • Vajrychová Marie
    • Vaňousová Andrea
  • Laboratories
  • Working groups
  • Cooperation
  • Contact
  • Our projects
  • List of publications
Ministerstvo zdravotnictví České Republiky Akreditace, program kvality
Prohlášení o přístupnosti © Copyright 2022 FN HK. All rights reserved. | webmaster