Postdoctoral fellow
+420 495 832 017
michaela.sadibolova@fnhk.cz
ORCID: 0000-0002-5527-3802
Michaela obtained her master’s degree in 2017 in Pharmacy at the Faculty of Pharmacy in Hradec Kralove, Charles University. In her thesis, she studied the effect of plant secondary metabolites on the efficacy of standard chemotherapeutic agents in colorectal cancer cells. Michaela successfully finished her doctoral studies at the Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University in 2024 and was awarded a PhD degree in Xenobiochemistry and Pathobiochemistry. In her dissertation, she investigated the biotransformation of plant secondary metabolites using LC-MS and evaluated their modulatory activity on drug-metabolizing enzymes. She is currently a postdoctoral fellow in a proteomics lab in Biomedical Research Center.
| PharmDr. | (2024) |
Charles University, Faculty of Pharmacy in Hradec Kralove, |
| Ph.D. | (2024) |
Charles University, Faculty of Pharmacy in Hradec Kralove, |
| MSc. | (2017) |
Charles University, Faculty of Pharmacy in Hradec Kralove, |
| 2024–present | R&D scientist, Biomedical Research Center, University Hospital Hradec Kralove |
| 2017–2018 | Researcher, Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University |
| Nov 2022–June 2023 | 8-month research internship in Germany (Heidelberg University, Heidelberg) in a proteomics core facility under the supervision of dr. Thomas Ruppert a dr. Marcin Luzarowski |
| Sept 2019–Feb 2020 | 6-month research internship in Finland (School of Pharmacy, University of Eastern Finland, Kuopio) in the research group of prof. Seppo Auriola and prof. Risto Juvonen |
Czech Society for Biochemistry and Molecular Biology
| Title: | Development of brain organoid models to study the role of cellular senescence in pathogenesis of glioblastoma |
| Funding: | Czech Science Foundation, grant No. 24-11357S |
| Implementation: | 2024-2026 |
| Role: | co-applicant |
| Title: | Transcriptomic, proteomic and functional analysis of carbonyl reductases in parasitic nematode Haemonchus contortus |
| Funding: | Czech Science Foundation, grant No. 20-14581Y |
| Implementation: | 2021–2023 |
| Role: | team member (in 2023) |
| Title: | Novel therapeutic approaches to the treatment of hepatic diseases |
| Funding: | Charles University Research Funding, grant No. START/MED/065 |
| Implementation: | 2021–2023 |
| Role: | principal investigator |
| Title: | The investigation of biotransformation of reactive sesquiterpenes and their effect on the proteome of human hepatic cells |
| Funding: | Charles University Grant Agency, grant No. GA UK 1302120 |
| Implementation: | 2020–2022 |
| Role: | principal investigator |
| Title: | Metabolism of terpenes and mechanisms of their toxic effects in human liver |
| Funding: | Czech Science Foundation, grant No. 18-09946S |
| Implementation: | 2018–2021 |
| Role: | team member |
| Title: | Circulation of anthelmintics in environment- does it contribute to drug resistance development in helminths? |
| Funding: | Czech Science Foundation, grant No. 18-07724S |
| Implementation: | 2018–2021 |
| Role: | team member (in 2018) |
2023
Pavicic A, Zajickova M, Sadibolova M, Svobodova G, Matouskova P, Szotakova B, Langhansova L, Marsik P, Skalova L. (2023) Anthelmintic activity of European fern extracts against Haemonchus contortus. Vet Res 54(59). IF2022 = 4.4
2022
Sadibolova M, Juvonen R O, Auriola S, Bousova I. (2022) In vitro metabolism of helenalin and its inhibitory effect on human cytochrome P450 activity. Arch Toxicol 96(3): 793–808. IF2022 = 6.1
2020
Lnenickova K, Sadibolova M, Matouskova P, Szotakova B, Skalova L and Bousova I. (2020) The Modulation of Phase II Drug-Metabolizing Enzymes in Proliferating and Differentiated CaCo-2 Cells by Hop-Derived Prenylflavonoids. Nutrients 12(7): 2138. IF2020 = 5.7
2019
Sadibolova M, Zarybnicky T, Smutny T, Pavek P, Subrt Z, Matouskova P, Skalova L and Bousova I. (2019) Sesquiterpenes Are Agonists of the Pregnane X Receptor but Do Not Induce the Expression of Phase I Drug-Metabolizing Enzymes in the Human Liver. Int J Mol Sci 20(18): 4562. IF2019 = 4.6
Ambroz M, Smatova M, Sadibolova M, Pospisilova E, Hadravska P, Kasparova M, Skarkova Hanusova V, Kralova V and Skalova L. (2019) Sesquiterpenes alpha-humulene and beta-caryophyllene oxide enhance the efficacy of 5-fluorouracil and oxaliplatin in colon cancer cells. Acta Pharm 69(1): 121-128. IF2019 = 1.4
Vokral I, Sadibolova M, Podlipna R, Lamka J, Prchal, Sobotova D, Lokvencova K, Szotakova B and Skalova L. (2019) Ivermectin environmental impact: Excretion profile in sheep and phytotoxic effect in Sinapis alba. Ecotoxicol Environ Saf 169: 944-949. IF2019 = 4.9
