Excellence in Regenerative Medicine - Exregmed
Ministry of Education, Youth and Sports
Institute of Physiology CAS;Institute of Animal Physiology and Genetics CAS; Institute of Chemical Process Fundamentals of the CAS; Institute of Macromolecular Chemistry; University hospital Hradec Kralove; Palacky University Olomouc; Brno University of Technology; Jan Evangelista University Usti nad Labem; Technical University of Liberec; University of Chemistry and Technology in Prague
Regenerative medicine is a promising new field focused on the repair or replacement of tissues or organs that have lost function due to age, disease, damage or birth defects. It is a multidisciplinary field involving tissue engineering, molecular biology and nanotechnology. The research agenda of the project is to create and develop an excellent research centre focused on R&D in the field of regenerative medicine therapeutic methods, which have the potential to produce applicable R&D results in the long term and which will contribute to the development of the Czech Republic's competitiveness in the field. The excellence and uniqueness of the project lies in the fact that its research aims at the restoration of tissues whose damage cannot yet be treated or whose regenerative capacity is significantly limited. These include, in particular, damage to the nervous tissue of the brain and spinal cord, including the problem of neurodegeneration and retinal degeneration, as well as small-diameter vessel replacements, which are still lacking on the market (or in clinical practice), and last but not least, active healing of chronic wounds and osteochondral defects, which are also among the major problems of modern civilised society. The unifying element of the whole project is "Medical devices for modern therapies", namely products for gene therapy, somatic cell therapy and tissue engineering products.
In order to perform whole organ regeneration, it is necessary to understand the mechanisms at the cellular and tissue level. The project research will therefore cover all levels, from the sub-cellular level to the cellular, tissue level, and will end with preclinical studies in small and large animals.
1-October 2023–30-Jun 2028