Professor of Toxicology
+420 603 906 789
toxicology@toxicology.cz
ORCID: 0000-0002-1261-9703
Currently professor of toxicology at the University of South Bohemia in Budweis, professor emeritus of the University of Defence, Brno. He works in the field of molecular biochemistry, enzymology and toxicology of extremely poisonous synthetically prepared and natural substances and drugs. He is the author or co-author of 18 scientific monographs and textbooks, such as Military Toxicology (2004), Nutritional toxicology (2008) and others. He has published in international journals and more than 200 scientific papers and many science popularization articles. His lectures includes more than 250 titles. He is a member of several domestic and international scientific societies and editorial boards of three scientific journals.
| Mgr. | (1962) | Brno University, Faculty of Science |
| RNDr. | (1972) | Brno University, Faculty of Science |
| Ass. professor | (1993) | Military Medical Academy, Hradec Kralove |
| Professor | (2000) | Military Medical Academy, Hradec Kralove |
He works in the field of molecular biochemistry, enzymology and toxicology extremely poisonous synthetically prepared and natural substances and drugs. It deals with the development of new treatments for nerve agent poisoning and drugs for Alzheimer's disease. Beyond the research activity is devoted to the management of students, teaching and science popularization.
| 2012-present | Research worker, Biomedical Research Center (BRC), University Hospital Hradec Kralove |
| 2005-present | Professor, Department of Radiology and Toxicology, Health and Social Studies, University of South Bohemia in Budweis |
| 1964-1974 | Research worker, Department of Toxicology, Military Medical Research Institute in Hradec Kralove |
| Doctorate in Biochemistry (MU Brno) Candidature of Biochemistry (Czechoslovak Academy of Sciences, Prague). Carrier scientific qualification stage IIa (1974) | |
| 1975-1984 | Scientific and research worker, Department of Toxicology, Military Medical Research Institute in Hradec Kralove. Carrier scientific qualification stage II (1974) |
| 1984-1990 | Senior research worker, Department of Toxicology, Military Medical Academy in Hradec Kralove |
| Carrier scientific qualification grade I (1989) | |
| 1991-2000 | Lecturer in Toxicology, Department of Toxicology, Military Medical Academy in Hradec Kralove |
| 1992 | Doctor of Science in Toxicology (ASCR) |
| 2000-2005 | Professor of Toxicology, Department of Toxicology, Military Medical Academy in Hradec Kralove |
| 1990 | Hungarian Academy of Sciences, Department of Biochemistry, Budapest, Hungaria (4 weeks) |
| 1992 | Military Medical Academy, Sofia, Bulgaria (2 weeks) |
| Title: | GA306/95/0268 - Úloha metabolitů arginin vasopresinu a některých dalších peptidů v učení a paměti podmíněných ovlivněním cholinergního přenosu (1995-1997, GA0/GA) |
| Funding: | Grantová agentura České republiky |
| Schedule: | 1995 -1997 |
| Role: | Team leader |
He has published more than 350 scientific papers and presented more than 200 lectures and posters on scientific meetings. Author and co-author of 18 books and/or textbooks, e.g. Military Toxicology (Grada, Prague 2004) or chapters in monograph, e.g. Handbook of the Toxicology of Chemical Warfare Agents (Academic Press/Elsevier 2009). More than 800 citations to SCI and more than 1300 to Google Scholar Citations, Hirsch-index = 21, i10 index = 39. Co-Editor of the Journal of Applied Biomedicine, the member of Editorial board of Military Medical Science Letters, Pharmaceutical Design and Current Perspectives, and Kontakt. His scientific work focuses on the biochemical mechanisms of toxic action of different biologically active compounds, mainly on inhibition of cholinesterases, include their application as Alzheimer's disease drugs and on the function of centrally active anticholinesterases and different peptides in teaching and memory processes. He follow to popularization of science and published hundreds of articles in specialized journals and newspapers – Vesmír, Živa, Zdravotnické noviny, MF Dnes, Lidové noviny and other. He is engaged Internet server TOXICOLOGY (http://www.toxicology,cz) much-frequented by students and persons concerned in toxicology.
(dated 10/2012)
Patočka J., Petroianu G, Kuča K. Toxic potential o superwarfarin brodifacoum. Mil Med Sci Lett. 2013, 82, 32-38.
Navrátilová Z, Patočka J. Léčivé účinky lopuchů. Prevence úrazů, otrav a násilí. 2013, 9, 51-58.
Patočka J, Soukup O, Kuča K. Ladostigil – další snaha o dualistické kognitivum. Psychiatrie 2013, 17, 71-73.
Navrátilová Z, Patočka J. Withania somnifera – indický ženšen. Psychiatrie 2013, 17, 141-144.
Soukup O, Jun D, Žďárová-Karasová J, Patočka J, Nusílek K, Korábečný J, Krušek J, Kaniaková M, Šepsová V, Mandíková J, Trejtnar F, Pohanka M, Drtinová L, Pavlík M. Tobin G, Kuča K. A resurrection of 7-MEOTA: A comparison with tacrine. Curr Alzheimer Res. 2013, 10, 893-906.
Navrátilová Z, Patočka J. Farmakologický potenciál leknínů. Kontakt 2013, 15, 324-329.
Patočka J, Soukup O, Kuča K. Resorcylic acid lactones as the protein kinase inhibitors: Naturaly occuring toxins. Mini Red Med Chem 2013, 13, 1873-1878.
Strunecká A, Blaylock RL, Patočka J. Aluminofluoride complexes: Phosphate analogues and a hidden hazard for living organisms. Curr Inorg Chem. 2012, 2, 8-18.
Patočka J. Natural cholinesterase inhibitors from mushrooms. Mil Med Sci Lett. 2012, 81, 40-44.
Patočka J, Pita R, Kuča K. Gyromitrin, mushroom toxin of Gyromitra spp. Milit Med Sci Lett. 2012, 81, 61-67.
Patočka J, Kuča K. Toxic alcohols: aliphatic saturated alcohols. Milit Med. Sci. Lett. 2012, 81, 141-162.
Patočka J. β-Aminoacids and their natural biologically active derivatives. 5. Derivatives of unusual alicyclic and heterocyclic β-aminoacids. Milit Med Sci Lett. 2011, 80, 61-67.
Patočka J, Kuča K. Phosgeneoxime – forgotten chemical weapon. Milit Med Sci Lett. 2011, 81, 38-41
Patočka J, Kuča K. Pelargonic acid vanillylamide (PAVA): Riot control agent. Milit Med Sci Lett. 2011, 81, 71-78.
Patočka J, Gupta RC, Kuča K. Anatoxin-a(s): natural organophosphorus anticholinesterase agent. Milit Med Sci Lett. 2011, 81, 130-140.
Patočka J, Kuča K. Syntetické kannabinoidy a “spice drugs”. Psychiatrie 2011, 15, 140-144.
Patočka J, Jakl J. Biomedically relevant chemical constituents of Valeriana officinalis. J Appl Biomed. 2010, 8, 11-18.
Patočka J. Beta-aminokyseliny a jejich přírodní biologicky aktivní deriváty I. Deriváty beta-alaninu a beta-leucinu. Voj Zdrav Listy 2010, 79, 15-22.
Kryštofíková Z, Patočka J, Řípová D. Stereospecific interactions of amyloid β-peptides. Psychiatrie 2010, 14, 18-21.
Patočka J, Hon Z. Ethylene glycol, hazardous substance in the household. Acta Medica (Hradec Kralove) 2010, 53, 19-23.
Hrdina V, Měrka V, Patočka J. Ayahuasca: exotická psychoaktivní droga nebo lék budoucnosti? Psychiatrie 2010, 14, 80-84.
Patočka J. Dimebolin – stare léčivo v nové medikaci. Psychiatrie 2010, 14, 109-111.
Patočka J. Beta-aminokyseliny a jejich přírodní biologicky aktivní deriváty II. Deriváty beta-lysinu a beta-argininu. Voj Zdrav Listy 2010, 79, 50-53.
Patočka J, Hon Z. Chlortrifluorid – atypická dusivá otravná látka. Voj Zdrav Listy 2010, 72-75.
Patočka J. Beta-aminokyseliny a jejich přírodní biologicky aktivní deriváty III. Deriváty beta-fenylalaninu a beta-tyrosinu. Voj Zdrav Listy 2010, 79, 114-118.
Soukup O, KrIštofíková Z, Proška J, Tobinm G, Patočka J, Marek J, Jun D, Fusek J, Řípová D, Kuča K. Novel acetylcholinesterase reactivator K112 and the cholinergic properties. Biomed Pharmacotherap. 2010, 64, 541-545.
Patočka J., Kuča K.Pozoruhodná molekula AF267B a Alzheimerova nemoc. Psychiatrie 2010, 14, 209-211.
Korábečný J, Musílek Km Holas O, Nepovímová E, Jun D, Zemek F, Opletalová V, Patočka J, Dohnal V, Nachon F, Hor J, Fišar Z, Kuča K. Synthesis and in vitro evaluation of N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment. Molecules 2010, 15, 8804-8812.
Patočka J. Beta-aminokyseliny a jejich přírodní biologicky aktivní deriváty IV. Deriváty neobvyklých acyklických beta-aminokyselin. Voj Zdrav Listy 2010, 79, 151-153.
