Junová Lucie | Centrum biomedicínského výzkumu

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Junová Lucie

Info

For Czech version click here

Post-doctoral fellow
+420 973 255 155
lucie.junova@fnhk.cz
ORCID: 0000-0002-1676-4932


Lucie obtained her PhD in 2009 at the Faculty of Pharmacy in Hradec Kralove, Charles University in Prague. The main goal of the doctoral thesis was chemical modification of the enzyme phosphotriesterase using biocompatible polymers, subsequent purification and biochemical characterization of prepared conjugates and their in vivo study. Second part of the thesis was focused on testing of reactivation efficacy of oxime reactivators using organophophate pesticide-inhibited butyrylcholinesterase. Currently, she works as research and development fellow at the Biomedical Research Centre, University Hospital Hradec Kralove and she is responsible for testing of cholinesterase modulatos usable as new drugs. She is an assistant professor in Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence at the same time.

 

Education

Ph.D.

(2009)

Charles University in Prague, Faculty of Pharmacy Hradec Kralove in cooperation with Department of Toxicology, Faculty of Military Health Sciences, University of Defence
Doctoral thesis title: Bioscavengers as Prophylactics of Poisonings Caused by Organophosphate Inhibitors of Acetylcholinesterase (supervisor prof. RNDr. Lenka Skálová, Ph.D.; supervisor consultant: Col. assoc. prof. PharmDr. Daniel Jun, Ph.D.)

PharmDr.

(2009)

Charles University in Prague, Faculty of Pharmacy Hradec Kralove

MSc.

(2006)

Charles University in Prague, Faculty of Pharmacy Hradec Kralove

Diploma thesis title: Pattern of expression of TRAIL and its receptors DR5 and DcR2 in rat uterine tissues during pregnancy (supervisors: Prof. Ing. Barbora Szotáková, Ph.D., assoc.prof. Georgina Lopes Correia da Silva, thesis worked on Universidade do Porto)

 

Research focus

Evaluation of cholinesterase modulators

In vitro testing of inhibition and reactivation efficacy of new drugs on cholinesterases

 

Professional training

Since 2018

Assistant professor in Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence
Research a development fellow, Biomedical Research Centre, University Hospital Hradec Kralove

2017 - 2018

Pharmacist in Hospital Pharmacy, University Hospital Hradec Kralove

2012 - 2017

Maternity leave

2009 - 2012 

Pharmacist in Hospital Pharmacy, University Hospital Hradec Kralove

2007 - 2009

Translations (ENG – CZE), Contract research organization, Prague

 

International experience

2008

Centre de recherches du service de santé des armées), La Tronche, France (Purification, evaluation and PEGylation of organophosphate-hydrolyzing enzymes; two-month research stay) 

2008

Institute for Medical Research and Occupational Health, Zagreb, Croatia (Reactivation of organophosphate-inhibited cholinesterases, two-week research stay)

2007

Centre de recherches du service de santé des armées), La Tronche, France (Purification, evaluation and PEGylation of organophosphate-hydrolyzing enzymes; three-month research stay)

2006

Universidade do Porto, Portugal (ERASMUS, 5 months – working on diploma thesis) 

 

Membership in scientific organizations and councils

Czech Pharmaceutical Society ČLS JEP - member

 

Projects

2018-2020

GAČR: Reaktivátory butyrylcholinesterasy pro přípravu pseudo katalytických scavengerů využitelných při intoxikacích organofosforovými sloučeninami (member of  a team)

2018-2021

Vývoj polyvalentního dekontaminačního činidla (member of  a team)

2017-2020 

Ministry of Defence: Long term development plan (DZRO ZHN) (member of  a team)

2009 Project DGA 08co501 – „Bioépurateurs catalytiques des neurotoxiques organophosphorés: Optimisation et Fonctionnalisation“, solved in cooperation with French workplace (C.R.S.S.A. - Centre de recherches du service de santé des armées, La Tronche, Francie); (member of  a team)
2008-2009 

Institutional research plan MO0FVZ0000604 - Information support of crises management in health care (2006-2011, MO0), Ministry of Defence (Czech Republic) (member of  a team)

2008-2009  NATO grant „Butyrylcholinesterase and aldoximes - bioscavengers for detoxification of organophosphates“ (CBP.EAP.CLG 983 024); (member of  a team)

 

Awards

2009

3rd place Prix de Pharmacie 2010 by Sanofi-Aventis and French Embassy in the Czech Republic 

 

Obtained scholarship

2008 Scholarship from French embassy for two-month research stay in France 
2007 Scholarship from French embassy for three-month research stay in France

 

Publication activity

Author or co-author of 13 scientific publications with IF

Co-autor of 1 book chapter

H-index: 9

Citations without autocitations: 200

(dated 5/2019)

 

Selected publications

KUCA, Kamil, Daniel JUN, Lucie JUNOVA, Kamil MUSILEK, Martina HRABINOVA, Jorge Alberto VALLE DA SILVA, Teodorico Castro RAMALHO, Marian VALKO, Qinghua WU, Eugenie NEPOVIMOVA a Tanos Celmar COSTA FRANCA. Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon. Molecules [online]. 2018, 23(5), 1103. ISSN 1420-3049. Dostupné z: doi:10.3390/molecules23051103

TROVASLET-LEROY, Marie, Lucie MUSILOVA, Frederique RENAULT, Xavier BRAZZOLOTTO, Jan MISIK, Ladislav NOVOTNY, Marie-Therese FROMENT, Emilie GILLON, Melanie LOIODICE, Laurent VERDIER, Patrick MASSON, Daniel ROCHU, Daniel JUN a Florian NACHON. Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents. Toxicology Letters [online]. 2011, 206(1), 14–23. ISSN 0378-4274. Dostupné z: doi:10.1016/j.toxlet.2011.05.1041 

JUN, Daniel, Lucie MUSILOVA, Kamil MUSILEK a Kamil KUCA. In Vitro Ability of Currently Available Oximes to Reactivate Organophosphate Pesticide-Inhibited Human Acetylcholinesterase and Butyrylcholinesterase. International Journal of Molecular Sciences [online]. 2011, 12(3), 2077–2087. ISSN 1422-0067. Dostupné z: doi:10.3390/ijms12032077 

MUSILOVA, Lucie, Daniel JUN, Jiri PALECEK, Vladimir CIRKVA, Kamil MUSILEK, Martin PAAR, Martina HRABINOVA, Miroslav POHANKA a Kamil KUCA. Novel Nucleophilic Compounds with Oxime Group as Reactivators of Paraoxon-Inhibited Cholinesterases. Letters in Drug Design & Discovery [online]. 2010, 7(4), 260–264. ISSN 1570-1808. Dostupné z: doi:10.2174/157018010790945823 

KOVARIK, Zrinka, Maja KATALINIC, Goran SINKO, Jiri BINDER, Ondrej HOLAS, Young-Sik JUNG, Lucie MUSILOVA, Daniel JUN a Kamil KUCA. Pseudo-catalytic scavenging: Searching for a suitable reactivator of phosphorylated butyrylcholinesterase. Chemico-Biological Interactions [online]. 2010, 187(1–3), 167–171. ISSN 0009-2797. Dostupné z: doi:10.1016/j.cbi.2010.02.023 

JUN, Daniel, Lucie MUSILOVA, Miroslav POHANKA, Young-Sik JUNG, Pavel BOSTIK a Kamil KUCA. Reactivation of Human Acetylcholinesterase and Butyrylcholinesterase Inhibited by Leptophos-Oxon with Different Oxime Reactivators in Vitro. International Journal of Molecular Sciences [online]. 2010, 11(8), 2856–2863. ISSN 1422-0067. Dostupné z: doi:10.3390/ijms11082856 

JUN, Daniel, Lucie MUSILOVA, Marek LINK, Melanie LOIODICE, Florian NACHON, Daniel ROCHU, Frederique RENAULT a Patrick MASSON. Preparation and characterization of methoxy polyethylene glycol-conjugated phosphotriesterase as a potential catalytic bioscavenger against organophosphate poisoning. Chemico-Biological Interactions [online]. 2010, 187(1–3), 380–383. ISSN 0009-2797. Dostupné z: doi:10.1016/j.cbi.2010.03.017 

MUSILOVA, Lucie, Kamil KUCA, Young-Sik JUNG a Daniel YUN. In vitro oxime-assisted reactivation of paraoxon-inhibited human acetylcholinesterase and butyrylcholinesterase. Clinical Toxicology [online]. 2009, 47(6), 545–550. ISSN 1556-3650. Dostupné z: doi:10.1080/15563650903058914 

KUCA, Kamil, Lucie MUSILOVA, Jiri PALECEK, Vladimir CIRKVA, Martin PAAR, Kamil MUSILEK, Martina HRABINOVA, Miroslav POHANKA, Jana Zdarova KARASOVA a Daniel JUN. Novel Bisquaternary Oximes-Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon. Molecules [online]. 2009, 14(12), 4915–4921. ISSN 1420-3049. Dostupné z: doi:10.3390/molecules14124915 

KUCA, Kamil, Kamil MUSILEK, Daniel JUN, Miroslav POHANKA, Jana Zd’arova KARASOVA, Ladislav NOVOTNY a Lucie MUSILOVA. Could oxime HI-6 really be considered as „broad-spectrum" antidote? Journal of Applied Biomedicine [online]. 2009, 7(3), 143–149. ISSN 1214-0287. Dostupné z: doi:10.32725/jab.2009.016 

KUCA, Kamil, Jiri CABAL, Yung Sik JUNG, Kamil MUSILEK, Ondrej SOUKUP, Daniel JUN, Miroslav POHANKA, Lucie MUSILOVA, Jana KARASOVA, Ladislav NOVOTNY a Martina HRABINOVA. Reactivation of Human Brain Homogenate Cholinesterases Inhibited by Tabun using Newly Developed Oximes K117 and K127. Basic & Clinical Pharmacology & Toxicology [online]. 2009, 105(3), 207–210. ISSN 1742-7835. Dostupné z: doi:10.1111/j.1742-7843.2009.00421.x

JUN, D., L. MUSILOVA, K. KUCA, J. KASSA a J. BAJGAR. Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro. Chemico-Biological Interactions [online]. 2008, 175(1–3), 421–424. ISSN 0009-2797. Dostupné z: doi:10.1016/j.cbi.2008.05.004 

KUCA, Kamil, Daniel JUN, Jiri CABAL a Lucie MUSILOVA. Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases: An in vitro study. Basic & Clinical Pharmacology & Toxicology [online]. 2007, 101(1), 25–28. ISSN 1742-7835. Dostupné z: doi:10.1111/j.1742-7843.2007.00085.x


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